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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Abnormal peripheral myelination
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Accession:HP:0003130 term browser browse the term
Definition:An abnormality of the myelination of motor and sensory peripheral nerves. These are axons for motor nerves and dendrites for sensory nerves in the strict anatomic sense.
Comment:This finding may be observed upon biopsy of the sural nerve. Myelination, i.e., the presence of a segmented lipid-rich sheath (myelin), enables faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system (GO:0022011).
Synonyms:alt_id: HP:0003408
 xref: UMLS:C4025648


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Abnormal myelination 0
            Abnormal peripheral myelination 0
              Decreased number of peripheral myelinated nerve fibers + 0
              Delayed peripheral myelination 0
              Onion bulb formation + 0
              Peripheral amyelination 0
              Peripheral demyelination + 0
              Peripheral dysmyelination 0
              Peripheral hypermyelination + 0
              Peripheral hypomyelination 0
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