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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Granulomatosis
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Accession:HP:0002955 term browser browse the term
Definition:A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity.
Comment:This finding can be demonstrated by tissue biopsy. A granuloma is a compact (organized) collection of mature mononuclear phagocytes (macrophages and/or epithelioid cells) which may or may not be accompanied by accessory features such as necrosis or the infiltration of other inflammatory leukocytes (Adams DO. The granulomatous inflammatory response. Am J Pathol 1976:84:163-192).
Synonyms:xref: SNOMEDCT_US:443138004;   SNOMEDCT_US:44328006;   UMLS:C0521173


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Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of blood and blood-forming tissues 0
        Abnormal leukocyte morphology 0
          Abnormal myeloid leukocyte morphology 0
            Abnormal macrophage morphology 0
              Granulomatosis 0
                Cerebral granulomatosis 0
                Cutaneous granulomatosis 0
                Gastrointestinal granulomatosis 0
                Hepatic granulomatosis 0
                Lipogranulomatosis 0
                Non-caseating epithelioid cell granulomatosis 0
                Splenic granulomatosis 0
                Urinary bladder granulomatosis 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormal immune system morphology 0
          Abnormal cellular immune system morphology 0
            Abnormal leukocyte morphology 0
              Abnormal myeloid leukocyte morphology 0
                Abnormal macrophage morphology 0
                  Granulomatosis 0
                    Cerebral granulomatosis 0
                    Cutaneous granulomatosis 0
                    Gastrointestinal granulomatosis 0
                    Hepatic granulomatosis 0
                    Lipogranulomatosis 0
                    Non-caseating epithelioid cell granulomatosis 0
                    Splenic granulomatosis 0
                    Urinary bladder granulomatosis 0
paths to the root