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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Abnormal B cell morphology
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Accession:HP:0002846 term browser browse the term
Definition:A structural abnormality of B cells.
Comment:B cells are bursal or bone marrow-derived lymphocytes whose principle function in the adaptive immune system is to make antibodies against antigens. A simple definition of B lymphocytes is a population of cells that express clonally diverse cell surface immunoglobulin (Ig) receptors recognizing specific antigenic epitopes. Over 10 B cell-specific cell surface molecules have been identified by monoclonal antibodies, including CD19, which is considered a pan-B cell and possibly follicular dendritic cell marker, and CD20, which is considered to be a marker for mature B cells.
Synonyms:exact_synonym: Abnormal B cells;   Abnormality of B cells
 xref: UMLS:C4021748


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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of blood and blood-forming tissues 0
        Abnormal leukocyte morphology 0
          Abnormal lymphocyte morphology 0
            Abnormal B cell morphology 0
              Abnormal B cell count + 0
              Abnormal plasma cell count + 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormal immune system morphology 0
          Abnormal cellular immune system morphology 0
            Abnormal leukocyte morphology 0
              Abnormal lymphocyte morphology 0
                Abnormal B cell morphology 0
                  Abnormal B cell count + 0
                  Abnormal plasma cell count + 0
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