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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

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Accession:HP:0002797 term browser browse the term
Definition:Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium.
Comment:Osteolysis may be a feature of neoplastic, infectious, metabolis, vascular, and joint disorders and is also a component of many hereditary diseases. Osteolysis may be highly localized or more diffuse. This term is meant to group the more specific osteolysis terms.
Synonyms:exact_synonym: Breakdown of bone;   Increased bone resorption;   Osteolytic defects of bones
 narrow_synonym: periprosthetic osteolysis
 alt_id: HP:0010737
 xref: EFO:0009761;   MESH:D010014;   SNOMEDCT_US:203522001;   SNOMEDCT_US:30425001;   UMLS:C0221204

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the musculoskeletal system 0
        Abnormality of the skeletal system 0
          Abnormal skeletal morphology 0
            Abnormal bone structure 0
              Osteolysis 0
                Mandibular osteolysis 0
                Osteolysis involving bones of the lower limbs + 0
                Osteolysis involving bones of the upper limbs + 0
                Patchy reduction of bone mineral density 0
                Progressive clavicular acroosteolysis 0
                Rib osteolysis 0
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