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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Alzheimer disease
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Accession:HP:0002511 term browser browse the term
Definition:A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads.
Comment:Note that this is a bundled term that refers to a disease rather than to phenotypic features. It is retained for convenience since Alzheimer disease is used for annotation of other diseases (e.g., Down syndrome) as if it were a feature. If possible it is preferable to annotate with the precise phenotypic features.
Synonyms:exact_synonym: Late-onset form of familial Alzheimer disease
 narrow_synonym: Alzheimer's disease neuropathologic change
 alt_id: HP:0006878;   HP:0007213
 xref: DOID:10652;   EFO:0006801;   MONDO:0004975;   SNOMEDCT_US:230267005;   SNOMEDCT_US:26929004;   UMLS:C0002395;   UMLS:C1863051

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Morphological central nervous system abnormality 0
            Alzheimer disease 0
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