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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Distal muscle weakness
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Accession:HP:0002460 term browser browse the term
Definition:Reduced strength of the musculature of the distal extremities.
Comment:Typically, at onset the lower limbs are more affected than upper limbs. The distribution of weakness is often roughly symmetric.
Synonyms:exact_synonym: Distal limb muscle weakness;   Distal limb weakness;   Distal muscular weakness;   Distal paresis;   Muscle weakness, distal limbs, due to neuronopathy;   Weakness of distal muscles;   Weakness of outermost muscles
 alt_id: HP:0002598;   HP:0002935;   HP:0003497;   HP:0006940;   HP:0009008
 xref: SNOMEDCT_US:249942005;   UMLS:C0427065;   UMLS:C1864696

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Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the musculoskeletal system 0
        Abnormality of the musculature 0
          Abnormal muscle physiology 0
            Muscle weakness 0
              Distal muscle weakness 0
                Distal lower limb muscle weakness + 0
                Distal upper limb muscle weakness 0
                First dorsal interossei muscle weakness 0
                Late-onset distal muscle weakness 0
                Paresis of extensor muscles of the big toe 0
                Progressive distal muscle weakness 0
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