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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Neurofibrillary tangles
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Accession:HP:0002185 term browser browse the term
Definition:Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form.
Synonyms:exact_synonym: Neurofibrillary tangles composed of disordered microtubules in neurons;   Paired helical filaments
 alt_id: HP:0003132;   HP:0007070
 xref: MESH:D016874;   SNOMEDCT_US:85775002;   UMLS:C0085400

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Morphological central nervous system abnormality 0
            Abnormal brain morphology 0
              Abnormal forebrain morphology 0
                Abnormal cerebral morphology 0
                  Cerebral inclusion bodies 0
                    Neurofibrillary tangles 0
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