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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Abnormality of extrapyramidal motor function
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Accession:HP:0002071 term browser browse the term
Definition:A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless).
Comment:The basal ganglia, paired subcortical masses of gray matter that form distinct nuclei, subserve motor functions that are distinct from those of the pyramidal (i.e., corticospinal) tract. This is a bundled term that is kept for historical reasons, but it is preferable to annotate the precise abnormalities observed.
Synonyms:exact_synonym: Extrapyramidal dysfunction;   Extrapyramidal signs;   Extrapyramidal symptoms;   Extrapyramidal syndrome;   Extrapyramidal tract signs
 alt_id: HP:0006810;   HP:0007113
 xref: SNOMEDCT_US:43378000;   SNOMEDCT_US:76349003;   UMLS:C0015371;   UMLS:C0234133


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system physiology 0
          Abnormal central motor function 0
            Abnormality of extrapyramidal motor function 0
              Athetoid cerebral palsy 0
              Bradykinesia 0
              Exaggerated startle response 0
              Extrapyramidal dyskinesia 0
              Extrapyramidal muscular rigidity + 0
              Parkinsonism + 0
              Progressive extrapyramidal movement disorder 0
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