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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Extramedullary hematopoiesis
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Accession:HP:0001978 term browser browse the term
Definition:The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms.
Comment:During fetal life, the formation of cellular blood components occurs mainly in the liver, shifting to the bone marrow postnatally. Some pathological conditions associated with a severe reduction of marrow hematopoiesis are associated with extramedullary hematopoiesis. The most common causes of Extramedullary hematopoieses (EMH) are myelofibrosis, diffuse osseous metastatic disease replacing the bone marrow, leukemia, sickle-cell anemia, and thalassemia. EMH is usually microscopic and asymptomatic, but it can sometimes manifest as organomegaly and tumor-like masses. Rarely, it can cause cord compression, pleural effusion, massive hemothorax, and respiratory failure.
Synonyms:related_synonym: Extramedullary erythropoiesis
 alt_id: HP:0004847
 xref: SNOMEDCT_US:124958002;   SNOMEDCT_US:42952007;   UMLS:C1292120;   UMLS:C2613439


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of blood and blood-forming tissues 0
        Extramedullary hematopoiesis 0
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