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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Hepatic steatosis
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Accession:HP:0001397 term browser browse the term
Definition:Steatosis is a term used to denote lipid accumulation within hepatocytes.
Comment:Although steatosis is the hallmark of the fatty liver disease, it is not a specific feature because it can be seen as part of other disease processes, such as drug injury, Wilson disease, or hepatitis C virus infection (especially genotype-3). Involvement of less than 5% of the hepatocytes by steatosis is considered clinically insignificant and within reference range. Based on the morphologic appearance and the size of the lipid droplets within the cytoplasm of the hepatocytes, steatosis is characterized as macrovesicular or microvesicular. Macrovesicular steatosis is characterized by large lipid droplets occupying the cytoplasm, displacing the nucleus to the periphery (large droplet macrovesicular steatosis) or multiple small lipid droplets of variable size occupying the cytoplasm with the nucleus maintaining its central location (small droplet macrovesicular steatosis). Microvesicular steatosis is characterized by innumerable tiny, relatively uniform lipid vacuoles that result in a bubbly appearance of the hepatocytes.
Synonyms:exact_synonym: Fatty infiltration of liver;   Fatty liver;   Liver steatosis;   Steatosis
 alt_id: HP:0002252;   HP:0200121
 xref: MESH:D005234;   SNOMEDCT_US:197321007;   SNOMEDCT_US:442191002;   UMLS:C2711227

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the digestive system 0
        Abnormality of the abdominal organs 0
          Abnormality of the liver 0
            Abnormal liver morphology 0
              Storage in hepatocytes 0
                Lipid accumulation in hepatocytes 0
                  Hepatic steatosis 0
                    Acute hepatic steatosis 0
                    Diffuse hepatic steatosis 0
                    Macrovesicular hepatic steatosis 0
                    Microvesicular hepatic steatosis 0
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