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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Muscle weakness
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Accession:HP:0001324 term browser browse the term
Definition:Reduced strength of muscles.
Comment:It is important clinical to distinguish between muscle weakness, fatigue, and asthenia. Fatigue describes the inability to continue performing a task after multiple repetitions; in contrast, a patient with primary weakness is unable to perform the first repetition of the task. Asthenia is a sense of weariness or exhaustion in the absence of muscle weakness. Conditions that result in intrinsic muscle weakness can be divided into several main categories: infectious, neurologic, endocrine, inflammatory, rheumatologic, genetic, metabolic, electrolyte-induced, or drug-induced.
Synonyms:exact_synonym: Muscular weakness
 alt_id: HP:0002309;   HP:0008979;   HP:0009012;   HP:0009061
 xref: SNOMEDCT_US:26544005;   UMLS:C0151786


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the musculoskeletal system 0
        Abnormality of the musculature 0
          Abnormal muscle physiology 0
            Muscle weakness 0
              Abdominal wall muscle weakness + 0
              Ankle weakness 0
              Axial muscle weakness 0
              Bulbar palsy 0
              Cold paresis 0
              Diaphragmatic weakness + 0
              Distal muscle weakness + 0
              Facial palsy + 0
              Fatigable weakness + 0
              Generalized muscle weakness 0
              Intercostal muscle weakness 0
              Limb muscle weakness + 0
              Limb-girdle muscle weakness + 0
              Muscle flaccidity + 0
              Neck muscle weakness + 0
              Poor head control 0
              Progressive muscle weakness + 0
              Proximal muscle weakness + 0
              Scapuloperoneal weakness 0
              Weakness of muscles of respiration + 0
              Weakness of orbicularis oculi muscle 0
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