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The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Muscle weakness
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Accession:HP:0001324 term browser browse the term
Definition:Reduced strength of muscles.
Comment:It is important clinical to distinguish between muscle weakness, fatigue, and asthenia. Fatigue describes the inability to continue performing a task after multiple repetitions; in contrast, a patient with primary weakness is unable to perform the first repetition of the task. Asthenia is a sense of weariness or exhaustion in the absence of muscle weakness. Conditions that result in intrinsic muscle weakness can be divided into several main categories: infectious, neurologic, endocrine, inflammatory, rheumatologic, genetic, metabolic, electrolyte-induced, or drug-induced.
Synonyms:exact_synonym: Muscular weakness
 alt_id: HP:0002309;   HP:0008979;   HP:0009012;   HP:0009061
 xref: MSH:D018908;   SNOMEDCT_US:26544005;   UMLS:C0151786

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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the musculoskeletal system 0
        Abnormality of the musculature 0
          Abnormal muscle physiology 0
            Muscle weakness 0
              Abdominal wall muscle weakness + 0
              Ankle weakness 0
              Axial muscle weakness 0
              Bulbar palsy 0
              Cold paresis 0
              Diaphragmatic weakness + 0
              Distal muscle weakness + 0
              Facial palsy + 0
              Fatigable weakness + 0
              Generalized muscle weakness 0
              Intercostal muscle weakness 0
              Limb muscle weakness + 0
              Limb-girdle muscle weakness + 0
              Muscle flaccidity + 0
              Neck muscle weakness + 0
              Poor head control 0
              Progressive muscle weakness + 0
              Proximal muscle weakness + 0
              Scapuloperoneal weakness 0
              Weakness of muscles of respiration + 0
              Weakness of orbicularis oculi muscle 0
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