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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.

Term:Acne
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Accession:HP:0001061 term browser browse the term
Definition:A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts).
Comment:Acne can be a consequence of increased sebum production as a result of increased testosterone production (in males and females) during puberty. Blockage of hair follicles canresult from accumulating keratin and sebum, resulting in plug formation called microcomedone, which can enlarge just beneath the surface of the skin in the pore itself. It may become visible as a closed comedone (whitehead), a firm white papule. Further enlargement leads to an open comedone (blackhead). The comedones are not themselves inflammatory. Proprionibacterium acnes can induce inflammation, leding to an inflammed, red papule.
Synonyms:broad_synonym: Breaking out
 alt_id: HP:0005596
 xref: EFO:0003894;   MEDDRA:10000496 "Acne";   SNOMEDCT_US:11381005;   UMLS:C0702166



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Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the integument 0
        Abnormality of the skin 0
          Abnormality of skin physiology 0
            Inflammatory abnormality of the skin 0
              Acne 0
                Acne inversa 0
                Comedonal acne 0
                Cystic acne 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormality of immune system physiology 0
          Abnormal inflammatory response 0
            Increased inflammatory response 0
              Inflammatory abnormality of the skin 0
                Acne 0
                  Acne inversa 0
                  Comedonal acne 0
                  Cystic acne 0
paths to the root