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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Hyperkeratosis
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Accession:HP:0000962 term browser browse the term
Definition:Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum.
Synonyms:alt_id: HP:0007523
 xref: MEDDRA:10020649 "Hyperkeratosis";   SNOMEDCT_US:26996000;   SNOMEDCT_US:396228006;   SNOMEDCT_US:399955009;   UMLS:C0870082


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the integument 0
        Abnormality of the skin 0
          Abnormal skin morphology 0
            Thickened skin 0
              Epidermal thickening 0
                Hyperkeratosis 0
                  Circumungual hyperkeratosis 0
                  Cobblestone-like hyperkeratosis 0
                  Epidermal hyperkeratosis 0
                  Follicular hyperkeratosis 0
                  Generalized hyperkeratosis 0
                  Gingival hyperkeratosis 0
                  Hyperkeratosis lenticularis perstans 0
                  Hyperkeratosis over edematous areas 0
                  Hyperkeratosis with erythema 0
                  Hyperkeratotic papule 0
                  Hyperparakeratosis 0
                  Linear arrays of macular hyperkeratoses in flexural areas 0
                  Orthokeratotic hyperkeratosis 0
                  Palmar hyperkeratosis + 0
                  Perifollicular hyperkeratosis 0
                  Periorificial hyperkeratosis + 0
                  Plantar hyperkeratosis + 0
                  Streaks of hyperkeratosis along each finger onto the palm 0
                  Subungual hyperkeratosis 0
                  Subungual hyperkeratotic fragments 0
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