Term: Eruption failure
Accession: HP:0000706
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Definition: A tooth which does not erupt within the teeth eruption timeline and after the loss of eruption potential.
Comment: Usually a tooth erupts at a stage of half or two-thirds of root formation. There are established norms for the timing of eruption and tooth stages in both deciduous and permanent teeth. It may be difficult to discern Delayed eruption from failure of eruption: failure indicates it will never erupt, delayed indicates it may still erupt. Eruption failure may be caused by an isolated obstacle (supernumerary teeth), ankylosis of impacted teeth, or disturbances of biological eruption pathway. Partial or complete non-eruption of not initially ankylosed teeth due to a disturbed eruption mechanism result in a severe form of posterior open bite that usually worsens from anterior to posterior. Eruption failure is usually asymmetrical, affects more posterior teeth and both dentition may be involved. The diagnosis eruption failure requires clinical and radiographic examinations.
Synonyms: exact_synonym: Failure of eruption of tooth; Pseudo-anodontia; Pseudoanodontia; Unerupted tooth
broad_synonym: Unerupted dentition
xref: SNOMEDCT_US:109542004; UMLS:C1290587
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ANTXR1
ANTXR cell adhesion molecule 1
IAGP
HPO
MIM:230740
NCBI chr 2:69,013,144...69,249,327
Ensembl chr 2:69,013,176...69,249,327
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APC
APC regulator of WNT signaling pathway
IAGP
HPO
MIM:175100
NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,518...112,846,239
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FGFR1
fibroblast growth factor receptor 1
IAGP
HPO
MIM:166250
NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834
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IFIH1
interferon induced with helicase C domain 1
IAGP
HPO
MIM:182250
NCBI chr 2:162,267,074...162,318,684
Ensembl chr 2:162,267,074...162,318,684
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LEMD2
LEM domain nuclear envelope protein 2
IAGP
HPO
MIM:619322
NCBI chr 6:33,771,213...33,789,130
Ensembl chr 6:33,771,202...33,789,130
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PTH1R
parathyroid hormone 1 receptor
IAGP
HPO
MIM:600002
NCBI chr 3:46,877,721...46,903,799
Ensembl chr 3:46,877,721...46,903,799
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TRIO
trio Rho guanine nucleotide exchange factor
IAGP
HPO
ORPHA:476126
NCBI chr 5:14,143,342...14,510,204
Ensembl chr 5:14,143,342...14,532,128
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FLNB
filamin B
IAGP
HPO
MIM:272460
NCBI chr 3:58,008,422...58,172,251
Ensembl chr 3:58,008,398...58,172,251
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MAP3K7
mitogen-activated protein kinase kinase kinase 7
IAGP
HPO
ORPHA:3238
NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086
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PTH1R
parathyroid hormone 1 receptor
IAGP
HPO
MIM:125350
NCBI chr 3:46,877,721...46,903,799
Ensembl chr 3:46,877,721...46,903,799
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SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
IAGP
HPO
ORPHA:2250
NCBI chr18:2,655,726...2,805,017
Ensembl chr18:2,655,726...2,805,017
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TCF4
transcription factor 4
IAGP
HPO
ORPHA:2896
NCBI chr18:55,222,185...55,635,957
Ensembl chr18:55,222,185...55,664,787
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CDH11
cadherin 11
IAGP
HPO
MIM:211380
NCBI chr16:64,943,753...65,123,744
Ensembl chr16:64,943,753...65,126,112
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LMNA
lamin A/C
IAGP
HPO
ORPHA:740
NCBI chr 1:156,082,573...156,140,081
Ensembl chr 1:156,082,572...156,140,081
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ZMPSTE24
zinc metallopeptidase STE24
IAGP
HPO
ORPHA:740
NCBI chr 1:40,258,236...40,294,180
Ensembl chr 1:40,258,041...40,294,180
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CDH11
cadherin 11
IAGP
HPO
MIM:211380
NCBI chr16:64,943,753...65,123,744
Ensembl chr16:64,943,753...65,126,112
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FLNA
filamin A
IAGP
HPO
MIM:311300
NCBI chr X:154,348,531...154,374,634
Ensembl chr X:154,348,524...154,374,634
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HOXD13
homeobox D13
IAGP
HPO
MIM:113300
NCBI chr 2:176,087,487...176,095,944
Ensembl chr 2:176,092,721...176,095,944
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PTH1R
parathyroid hormone 1 receptor
IAGP
HPO
MIM:600002
NCBI chr 3:46,877,721...46,903,799
Ensembl chr 3:46,877,721...46,903,799
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SH3BP2
SH3 domain binding protein 2
IAGP
HPO
MIM:118400
NCBI chr 4:2,793,085...2,841,096
Ensembl chr 4:2,793,023...2,841,291
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APC
APC regulator of WNT signaling pathway
IAGP
HPO
ORPHA:79665
NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,518...112,846,239
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FGFR1
fibroblast growth factor receptor 1
IAGP
HPO
ORPHA:2645
NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834
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LEMD2
LEM domain nuclear envelope protein 2
IAGP
ClinVar Annotator: match by term: Multiple unerupted teeth
ClinVar
PMID:25741868 PMID:30905398
NCBI chr 6:33,771,213...33,789,130
Ensembl chr 6:33,771,202...33,789,130
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PTH1R
parathyroid hormone 1 receptor
IAGP
HPO
MIM:600002
NCBI chr 3:46,877,721...46,903,799
Ensembl chr 3:46,877,721...46,903,799
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