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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cation channel activity
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Accession:GO:2001258 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
Synonyms:exact_synonym: negative regulation of cation diffusion facilitator activity;   negative regulation of nonselective cation channel activity


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negative regulation of cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 ISO RGD PMID:20624795 RGD:6849299 NCBI chrNW_004936589:2,504,235...2,536,778 JBrowse link
G Epo erythropoietin involved_in ISO (PMID:14569084) BHF-UCL PMID:14569084 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G Fgf12 fibroblast growth factor 12 ISO RGD PMID:12401812 RGD:6484231 NCBI chrNW_004936711:1,873,030...2,378,028 JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO (PMID:24164424) UniProt PMID:24164424 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
negative regulation of acid-sensing ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stoml1 stomatin like 1 acts_upstream_of_or_within ISO (MGI:5619720|PMID:24247984) MGI PMID:24247984 MGI:5619720 NCBI chrNW_004936471:33,123,662...33,133,017 JBrowse link
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in ISO (MGI:5613458|PMID:23903368) UniProt PMID:23903368 MGI:5613458 NCBI chrNW_004936614:2,664,594...2,976,174 JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 ISO RGD PMID:8183366 PMID:8799886 RGD:61642 RGD:9743956 NCBI chrNW_004936519:3,354,001...3,553,904 JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 involved_in ISO (PMID:19219384) UniProt PMID:19219384 RGD:7243947 NCBI chrNW_004936500:7,998,464...8,007,848 JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 involved_in ISO (PMID:19219384) UniProt PMID:19219384 RGD:7243947 NCBI chrNW_004936500:8,067,009...8,072,383 JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in ISO (PMID:12954870) UniProt PMID:12954870 RGD:10047250 NCBI chrNW_004936498:3,477,313...3,487,580 JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) UniProt PMID:9305853 NCBI chrNW_004936794:707,122...994,206 JBrowse link
G Kcnrg potassium channel regulator involved_in ISO (PMID:19968958) UniProt PMID:19968958 NCBI chrNW_004936565:2,991,568...2,997,592 JBrowse link
G Mtnr1b melatonin receptor 1B ISO RGD PMID:14962062 RGD:9588668 NCBI chrNW_004936674:1,703,814...1,713,860 JBrowse link
G Sumo1 small ubiquitin like modifier 1 involved_in ISO (PMID:19223394) UniProt PMID:19223394 NCBI chrNW_004936726:1,402,977...1,413,974 JBrowse link
negative regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 involved_in ISO (PMID:31454269) UniProt PMID:31454269 NCBI chrNW_004936488:17,580,425...17,588,480 JBrowse link
G Calm2 calmodulin 2 involved_in ISO (PMID:31454269) UniProt PMID:31454269 NCBI chrNW_004936508:5,207,909...5,223,780 JBrowse link
G Calm3 calmodulin 3 involved_in ISO (PMID:31454269) UniProt PMID:31454269 NCBI chrNW_004936664:471,446...480,858 JBrowse link
G Dysf dysferlin acts_upstream_of_or_within ISO (MGI:5545678|PMID:24302765) MGI PMID:24302765 MGI:5545678 NCBI chrNW_004936491:15,412,606...15,618,519 JBrowse link
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in ISO (PMID:18923542) BHF-UCL PMID:18923542 NCBI chrNW_004936589:2,504,235...2,536,778 JBrowse link
G Snx27 sorting nexin 27 ISO RGD PMID:21422294 RGD:8554349 NCBI chrNW_004936580:1,815,582...1,893,076 JBrowse link
negative regulation of large conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crbn cereblon involved_in ISO (MGI:6150698|PMID:29530986) UniProt PMID:29530986 MGI:6150698 NCBI chrNW_004936577:2,834,134...2,854,116 JBrowse link
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephb2 EPH receptor B2 involved_in ISO (MGI:4867584|PMID:21113149) ARUK-UCL PMID:21113149 MGI:4867584 NCBI chrNW_004936474:8,109,800...8,203,106 JBrowse link
G Park7 Parkinsonism associated deglycase ISO RGD PMID:20698836 RGD:13463453 NCBI chrNW_004936623:2,422,780...2,436,817 JBrowse link
G Slc6a9 solute carrier family 6 member 9 acts_upstream_of ISO (MGI:3044468|PMID:15159536) ARUK-UCL PMID:15159536 MGI:3044468 NCBI chrNW_004936474:25,312,544...25,344,993 JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chrNW_004936488:17,580,425...17,588,480 JBrowse link
G Calm2 calmodulin 2 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chrNW_004936508:5,207,909...5,223,780 JBrowse link
G Calm3 calmodulin 3 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chrNW_004936664:471,446...480,858 JBrowse link
G Casq2 calsequestrin 2 involved_in ISO (PMID:16601229)
PMID:17569730
(PMID:15041652)
BHF-UCL PMID:15041652 PMID:16601229 PMID:17569730 RGD:2314601 NCBI chrNW_004936627:1,001,681...1,069,377 JBrowse link
G Clic2 chloride intracellular channel 2 involved_in ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738 PMID:15916532 NCBI chrNW_004936927:514,989...543,691 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT|involved_in ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B involved_in ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chrNW_004936493:7,916,002...7,922,747 JBrowse link
G Gsto1 glutathione S-transferase omega 1 involved_in ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chrNW_004936600:1,932,152...1,943,342 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel acts_upstream_of_or_within ISO (MGI:3708075|PMID:17404231) MGI PMID:17404231 MGI:3708075 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Sri sorcin involved_in ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chrNW_004936763:715,884...728,548 JBrowse link
negative regulation of store-operated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ubqln1 ubiquilin 1 involved_in ISO (PMID:23307288) UniProt PMID:23307288 NCBI chrNW_004936828:543,651...588,673 JBrowse link
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cabp1 calcium binding protein 1 ISO RGD PMID:17960496 RGD:7207144 NCBI chrNW_004936668:324,299...339,334 JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F involved_in ISO (PMID:27226626) UniProt PMID:27226626 NCBI chrNW_004936721:1,078,570...1,106,153 JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:15024042 RGD:13514097 NCBI chrNW_004936512:6,652,836...6,666,171 JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 involved_in ISO (PMID:18292205) UniProt PMID:18292205 NCBI chrNW_004936541:2,288,847...2,333,129 JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO PMID:2162345
(PMID:7921596)
BHF-UCL PMID:2162345 PMID:7921596 RGD:8554169 NCBI chrNW_004936612:1,094,686...1,154,149 JBrowse link
G Drd4 dopamine receptor D4 involved_in ISO (PMID:7921596) BHF-UCL PMID:7921596 NCBI chrNW_004936888:468,334...471,254 JBrowse link
G Fmr1 FMRP translational regulator 1 involved_in ISO PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chrNW_004936513:1,290,038...1,327,850 JBrowse link
G Gnb5 G protein subunit beta 5 involved_in ISO (PMID:11007869), (PMID:12606627) UniProt PMID:11007869 PMID:12606627 NCBI chrNW_004936471:13,952,462...14,001,663 JBrowse link
G Gpr35 G protein-coupled receptor 35 involved_in ISO (PMID:17940199) UniProt PMID:17940199 NCBI chrNW_004936745:993,375...994,292 JBrowse link
G LOC101976074 CACN subunit beta associated regulatory protein involved_in ISO (MGI:5607190|PMID:24751537) RGD
UniProt
PMID:24751537 MGI:5607190 RGD:10047103 NCBI chrNW_004936588:601,108...607,823 JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO RGD PMID:15937148 RGD:9835002 NCBI chrNW_004936514:11,264,392...11,273,584 JBrowse link
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 involved_in ISO (PMID:10585425) CAFA PMID:10585425 NCBI chrNW_004936519:3,354,001...3,553,904 JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO RGD PMID:14679187 PMID:21943416 PMID:21943417 RGD:12910700 RGD:7242916 RGD:7243967 NCBI chrNW_004936500:7,998,464...8,007,848 JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO RGD PMID:14679187 PMID:19219384 PMID:21943416 RGD:7242916 RGD:7243947 RGD:7243967 NCBI chrNW_004936500:8,067,009...8,072,383 JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in ISO (PMID:22987075) RGD
BHF-UCL
PMID:14679187 PMID:22987075 RGD:7243967 NCBI chrNW_004936498:3,477,313...3,487,580 JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) UniProt PMID:9305853 NCBI chrNW_004936794:707,122...994,206 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12170
    negative regulation of biological process 4660
      negative regulation of transport 491
        negative regulation of transporter activity 79
          negative regulation of ion transmembrane transporter activity 70
            negative regulation of cation channel activity 42
              negative regulation of AMPA receptor activity 0
              negative regulation of NMDA glutamate receptor activity 3
              negative regulation of acetylcholine-gated cation channel activity 0
              negative regulation of acid-sensing ion channel activity 1
              negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
              negative regulation of large conductance calcium-activated potassium channel activity 1
              negative regulation of osmolarity-sensing cation channel activity 0
              negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
              negative regulation of ryanodine-sensitive calcium-release channel activity 10
              negative regulation of store-operated calcium channel activity 1
              negative regulation of voltage-gated calcium channel activity + 15
              negative regulation of voltage-gated potassium channel activity + 11
              negative regulation of voltage-gated sodium channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 12170
    biological regulation 8887
      regulation of biological process 8418
        regulation of localization 2620
          regulation of transport 1705
            regulation of transmembrane transport 484
              regulation of ion transmembrane transport 382
                regulation of ion transmembrane transporter activity 246
                  regulation of cation channel activity 168
                    negative regulation of cation channel activity 42
                      negative regulation of AMPA receptor activity 0
                      negative regulation of NMDA glutamate receptor activity 3
                      negative regulation of acetylcholine-gated cation channel activity 0
                      negative regulation of acid-sensing ion channel activity 1
                      negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
                      negative regulation of large conductance calcium-activated potassium channel activity 1
                      negative regulation of osmolarity-sensing cation channel activity 0
                      negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
                      negative regulation of ryanodine-sensitive calcium-release channel activity 10
                      negative regulation of store-operated calcium channel activity 1
                      negative regulation of voltage-gated calcium channel activity + 15
                      negative regulation of voltage-gated potassium channel activity + 11
                      negative regulation of voltage-gated sodium channel activity 0
paths to the root