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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cation channel activity
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Accession:GO:2001258 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
Synonyms:exact_synonym: negative regulation of cation diffusion facilitator activity;   negative regulation of nonselective cation channel activity


show annotations for term's descendants           Sort by:
 
negative regulation of cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 IDA RGD PMID:20624795 RGD:6849299 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Epo erythropoietin involved_in ISO (PMID:14569084) RGD PMID:14569084 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fgf12 fibroblast growth factor 12 IDA RGD PMID:12401812 RGD:6484231 NCBI chr11:71,997,049...72,564,965
Ensembl chr11:71,997,099...72,562,607
JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO
IEA
(PMID:24164424)
GO_REF:0000107
RGD
Ensembl
PMID:24164424 GO_REF:0000107 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
negative regulation of acid-sensing ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stoml1 stomatin like 1 acts_upstream_of_or_within ISO (MGI:5619720|PMID:24247984) RGD PMID:24247984 MGI:5619720 NCBI chr 8:58,661,980...58,669,860
Ensembl chr 8:58,661,992...58,669,860
JBrowse link
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5613458|PMID:23903368)
UniProt
RGD
PMID:23903368 GO_REF:0000024 MGI:5613458 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 involved_in IDA
IBA
IMP
PMID:21873635 RGD
GO_Central
PMID:8183366 PMID:21873635 PMID:8799886 RGD:61642, RGD:13792537, RGD:9743956 NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534
JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 involved_in IBA
IDA
ISO
PMID:21873635
PMID:19219384
(PMID:19219384)
RGD PMID:19219384 PMID:21873635 PMID:19219384 RGD:13792537, RGD:7243947 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901
JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 involved_in IDA
IBA
ISO
PMID:19219384
PMID:21873635
(PMID:19219384)
RGD PMID:19219384 PMID:19219384 PMID:21873635 RGD:7243947, RGD:13792537 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043
JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in IBA
IDA
ISO
PMID:21873635
PMID:12954870
(PMID:12954870)
RGD PMID:12954870 PMID:21873635 PMID:12954870 RGD:13792537, RGD:10047250 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020
JBrowse link
G Kcne4 potassium voltage-gated channel subfamily E regulatory subunit 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:80,243,429...80,251,533
Ensembl chr 9:80,247,379...80,250,979
JBrowse link
G Kcne5 potassium voltage-gated channel subfamily E regulatory subunit 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:105,930,398...105,931,013
Ensembl chr  X:105,930,398...105,931,013
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) RGD PMID:9305853 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Kcnrg potassium channel regulator involved_in ISO
IBA
(PMID:19968958)
PMID:21873635
RGD PMID:19968958 PMID:21873635 RGD:13792537 NCBI chr15:35,774,492...35,778,818
Ensembl chr15:35,774,326...35,779,415
JBrowse link
G Mtnr1b melatonin receptor 1B IDA RGD PMID:14962062 RGD:9588668 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:19223394)
UniProt
RGD
PMID:19223394 GO_REF:0000024 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761
JBrowse link
negative regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 involved_in ISO
ISS
(PMID:31454269)
GO_REF:0000024
RGD
UniProt
PMID:31454269 GO_REF:0000024 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calm2 calmodulin 2 involved_in ISO
ISS
(PMID:31454269)
GO_REF:0000024
RGD
UniProt
PMID:31454269 GO_REF:0000024 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Calm3 calmodulin 3 involved_in ISO
ISS
(PMID:31454269)
GO_REF:0000024
RGD
UniProt
PMID:31454269 GO_REF:0000024 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Dysf dysferlin acts_upstream_of_or_within ISO MGI:3055150 (MGI:5545678|PMID:24302765) RGD PMID:24302765 MGI:5545678 NCBI chr 4:116,490,877...116,690,709
Ensembl chr 4:116,490,616...116,690,709
JBrowse link
G Rem1 RRAD and GEM like GTPase 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:141,103,722...141,112,206
Ensembl chr 3:141,103,766...141,112,203
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator involved_in IEA GO_REF:0000104
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:18923542)
Ensembl
RGD
PMID:18923542 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Snx27 sorting nexin 27 IDA RGD PMID:21422294 RGD:8554349 NCBI chr 2:182,135,904...182,218,906
Ensembl chr 2:182,135,905...182,218,906
JBrowse link
negative regulation of large conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crbn cereblon involved_in ISO (MGI:6150698|PMID:29530986) RGD PMID:29530986 MGI:6150698 NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
JBrowse link
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephb2 Eph receptor B2 involved_in ISO (MGI:4867584|PMID:21113149) RGD PMID:21113149 MGI:4867584 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Park7 Parkinsonism associated deglycase IMP RGD PMID:20698836 RGD:13463453 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Slc6a9 solute carrier family 6 member 9 acts_upstream_of ISO (MGI:3044468|PMID:15159536) RGD PMID:15159536 MGI:3044468 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 involved_in ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calm2 calmodulin 2 involved_in ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Calm3 calmodulin 3 involved_in ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Casq2 calsequestrin 2 involved_in ISO
IEA
IMP
(PMID:16601229)
GO_REF:0000107
PMID:17569730
(PMID:15041652)
RGD
Ensembl
PMID:15041652 PMID:16601229 PMID:17569730 GO_REF:0000107, RGD:2314601 NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267
JBrowse link
G Clic2 chloride intracellular channel 2 involved_in ISO (PMID:15147738), (PMID:15916532) RGD PMID:15147738 PMID:15916532 NCBI chr20:149,337...164,375
Ensembl chr20:148,907...164,355
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT|involved_in ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B involved_in ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
JBrowse link
G Gstm2 glutathione S-transferase mu 2 involved_in ISO
IEA
(PMID:17023043), (PMID:22406107)
GO_REF:0000107
RGD
Ensembl
PMID:17023043 PMID:22406107 GO_REF:0000107 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm7 glutathione S-transferase, mu 7 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203
JBrowse link
G Gsto1 glutathione S-transferase omega 1 involved_in ISO
IEA
(PMID:11035031)
GO_REF:0000107
RGD
Ensembl
PMID:11035031 GO_REF:0000107 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel acts_upstream_of_or_within ISO (MGI:3708075|PMID:17404231) RGD PMID:17404231 MGI:3708075 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
JBrowse link
G Sri sorcin involved_in ISO (PMID:17699613) RGD PMID:17699613 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077
JBrowse link
negative regulation of store-operated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ubqln1 ubiquilin 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:23307288)
UniProt
Ensembl
RGD
PMID:23307288 GO_REF:0000024 GO_REF:0000107 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090
JBrowse link
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cabp1 calcium binding protein 1 IDA RGD PMID:17960496 RGD:7207144 NCBI chr12:41,385,234...41,448,930
Ensembl chr12:41,378,897...41,448,927
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F involved_in ISO (PMID:27226626) RGD PMID:27226626 NCBI chr  X:14,868,096...14,896,413
Ensembl chr  X:14,868,024...14,896,413
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IDA RGD PMID:15024042 RGD:13514097 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
JBrowse link
G Cbarp CACN subunit beta associated regulatory protein involved_in IMP
ISO
IBA
(MGI:5607190|PMID:24751537)
PMID:21873635
RGD PMID:24751537 PMID:24751537 PMID:21873635 MGI:5607190, RGD:10047103, RGD:13792537 NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:9,566,364...9,575,204
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 involved_in ISO (PMID:18292205) RGD PMID:18292205 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Drd2 dopamine receptor D2 involved_in IDA
IBA
ISO
PMID:2162345
PMID:21873635
(PMID:7921596)
RGD PMID:7921596 PMID:2162345 PMID:21873635 RGD:8554169, RGD:13792537 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd4 dopamine receptor D4 involved_in ISO
IEA
(PMID:7921596)
GO_REF:0000107
RGD
Ensembl
PMID:7921596 GO_REF:0000107 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Fmr1 FMRP translational regulator 1 involved_in IMP PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Gnb5 G protein subunit beta 5 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:11007869), (PMID:12606627)
CAFA
Ensembl
RGD
PMID:11007869 PMID:12606627 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:76,076,227...76,104,151
Ensembl chr 8:76,073,306...76,105,069
JBrowse link
G Gpr35 G protein-coupled receptor 35 involved_in ISO (PMID:17940199) RGD PMID:17940199 NCBI chr 9:93,526,691...93,539,302
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:15937148 RGD:9835002 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 involved_in ISO (PMID:10585425) RGD PMID:10585425 NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534
JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 IDA RGD PMID:14679187 PMID:21943416 PMID:21943417 RGD:7243967, RGD:7242916, RGD:12910700 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901
JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 IDA RGD PMID:19219384 PMID:21943416 PMID:14679187 RGD:7243947, RGD:7242916, RGD:7243967 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043
JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in IDA
ISO
(PMID:22987075) RGD PMID:22987075 PMID:14679187 RGD:7243967 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) RGD PMID:9305853 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    negative regulation of biological process 5613
      negative regulation of transport 529
        negative regulation of transporter activity 91
          negative regulation of ion transmembrane transporter activity 82
            negative regulation of cation channel activity 49
              negative regulation of AMPA receptor activity 0
              negative regulation of NMDA glutamate receptor activity 3
              negative regulation of acetylcholine-gated cation channel activity 0
              negative regulation of acid-sensing ion channel activity 1
              negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
              negative regulation of large conductance calcium-activated potassium channel activity 1
              negative regulation of osmolarity-sensing cation channel activity 0
              negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
              negative regulation of ryanodine-sensitive calcium-release channel activity 12
              negative regulation of store-operated calcium channel activity 1
              negative regulation of voltage-gated calcium channel activity + 18
              negative regulation of voltage-gated potassium channel activity + 13
              negative regulation of voltage-gated sodium channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of localization 3017
          regulation of transport 1995
            regulation of transmembrane transport 610
              regulation of ion transmembrane transport 505
                regulation of ion transmembrane transporter activity 278
                  regulation of cation channel activity 186
                    negative regulation of cation channel activity 49
                      negative regulation of AMPA receptor activity 0
                      negative regulation of NMDA glutamate receptor activity 3
                      negative regulation of acetylcholine-gated cation channel activity 0
                      negative regulation of acid-sensing ion channel activity 1
                      negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
                      negative regulation of large conductance calcium-activated potassium channel activity 1
                      negative regulation of osmolarity-sensing cation channel activity 0
                      negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
                      negative regulation of ryanodine-sensitive calcium-release channel activity 12
                      negative regulation of store-operated calcium channel activity 1
                      negative regulation of voltage-gated calcium channel activity + 18
                      negative regulation of voltage-gated potassium channel activity + 13
                      negative regulation of voltage-gated sodium channel activity 0
paths to the root