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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cation channel activity
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Accession:GO:2001258 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
Synonyms:exact_synonym: negative regulation of cation diffusion facilitator activity;   negative regulation of nonselective cation channel activity


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negative regulation of cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 ISO RGD PMID:20624795 RGD:6849299 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G EPO erythropoietin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936
JBrowse link
G FGF12 fibroblast growth factor 12 ISO RGD PMID:12401812 RGD:6484231 NCBI chr13:129,237,500...129,817,992
Ensembl chr13:129,240,067...129,817,466
JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
negative regulation of acid-sensing ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STOML1 stomatin like 1 acts_upstream_of_or_within ISO (MGI:5619720|PMID:24247984) MGI PMID:24247984 MGI:5619720 NCBI chr 7:59,448,500...59,461,208
Ensembl chr 7:59,452,117...59,462,615
JBrowse link
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 involved_in ISO (MGI:5613458|PMID:23903368) UniProt PMID:23903368 MGI:5613458 NCBI chr14:63,416,154...63,809,220 JBrowse link
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:8183366 PMID:8799886 PMID:21873635 RGD:61642 RGD:9743956 NCBI chr13:95,981,820...96,375,089
Ensembl chr13:95,959,577...96,375,856
JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 involved_in IBA
ISS
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000024 NCBI chr13:198,051,281...198,059,444 JBrowse link
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 involved_in ISO PMID:19219384
(PMID:19219384)
UniProt PMID:19219384 RGD:7243947 NCBI chr13:197,979,749...197,980,974 JBrowse link
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:8,810,716...8,822,191
Ensembl chr 9:8,810,722...8,821,817
JBrowse link
G KCNE4 potassium voltage-gated channel subfamily E regulatory subunit 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:124,910,708...124,915,787
Ensembl chr15:124,912,405...124,915,780
JBrowse link
G KCNE5 potassium voltage-gated channel subfamily E regulatory subunit 5 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:89,741,187...89,742,732
Ensembl chr  X:89,742,113...89,742,550
JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) UniProt PMID:9305853 NCBI chr 2:1,675,323...1,989,110
Ensembl chr 2:1,675,360...1,989,111
JBrowse link
G KCNRG potassium channel regulator involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:17,784,243...17,796,826
Ensembl chr11:17,784,996...17,793,804
JBrowse link
G MTNR1B melatonin receptor 1B ISO RGD PMID:14962062 RGD:9588668 NCBI chr 9:25,556,756...25,557,792
Ensembl chr 9:25,545,560...25,557,652
JBrowse link
G SUMO1 small ubiquitin like modifier 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,815,281...105,850,943
JBrowse link
negative regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:112,160,823...112,171,754
Ensembl chr 7:112,154,880...112,171,744
JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:31454269) UniProt PMID:31454269 NCBI chr 3:93,371,765...93,386,378
Ensembl chr 3:93,372,045...93,438,068
JBrowse link
G CALM3 calmodulin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:52,506,979...52,516,704
Ensembl chr 6:52,506,674...52,516,703
JBrowse link
G DYSF dysferlin acts_upstream_of_or_within ISO (MGI:5545678|PMID:24302765) MGI PMID:24302765 MGI:5545678 NCBI chr 3:71,020,143...71,237,658
Ensembl chr 3:71,020,141...71,246,967
JBrowse link
G GEM GTP binding protein overexpressed in skeletal muscle involved_in IEA UniProt GO_REF:0000104 NCBI chr 4:42,458,591...42,471,941
Ensembl chr 4:42,249,479...42,471,937
JBrowse link
G REM1 RRAD and GEM like GTPase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr17:35,208,344...35,218,771
Ensembl chr17:35,208,363...35,218,768
JBrowse link
G RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator involved_in IEA UniProt GO_REF:0000104 NCBI chr 6:27,601,692...27,605,127
Ensembl chr 6:27,601,692...27,605,083
JBrowse link
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G SNX27 sorting nexin 27 ISO RGD PMID:21422294 RGD:8554349 NCBI chr 4:97,533,643...97,620,816
Ensembl chr 4:97,525,151...97,620,789
JBrowse link
negative regulation of large conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRBN cereblon involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:59,733,503...59,757,776
Ensembl chr13:59,730,639...59,840,846
JBrowse link
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPHB2 EPH receptor B2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:80,649,098...80,849,979
Ensembl chr 6:80,649,143...80,843,567
JBrowse link
G PARK7 Parkinsonism associated deglycase ISO RGD PMID:20698836 RGD:13463453 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,520
JBrowse link
G SLC6A9 solute carrier family 6 member 9 acts_upstream_of ISO (MGI:3044468|PMID:15159536) ARUK-UCL PMID:15159536 MGI:3044468 NCBI chr 6:167,267,193...167,301,598
Ensembl chr 6:167,268,957...167,301,599
JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:112,160,823...112,171,754
Ensembl chr 7:112,154,880...112,171,744
JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr 3:93,371,765...93,386,378
Ensembl chr 3:93,372,045...93,438,068
JBrowse link
G CALM3 calmodulin 3 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr 6:52,506,979...52,516,704
Ensembl chr 6:52,506,674...52,516,703
JBrowse link
G CASQ2 calsequestrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:104,918,204...104,984,019
Ensembl chr 4:104,918,501...104,999,787
JBrowse link
G CLIC2 chloride intracellular channel 2 involved_in IEA Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chr  X:125,546,451...125,560,059
Ensembl chr  X:125,546,467...125,570,523
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A NOT|involved_in ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr17:33,910,047...33,935,212 JBrowse link
G FKBP1B FKBP prolyl isomerase 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:114,623,529...114,636,200
Ensembl chr 3:114,623,529...114,634,628
JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3708075|PMID:17404231) Ensembl
MGI
PMID:17404231 GO_REF:0000107 MGI:3708075 NCBI chr 8:131,002,973...131,058,932
Ensembl chr 8:131,005,407...131,058,932
JBrowse link
G SRI sorcin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:68,492,235...68,515,247
Ensembl chr 9:68,493,008...68,515,322
JBrowse link
negative regulation of store-operated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBQLN1 ubiquilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:31,275,916...31,317,521
Ensembl chr10:31,275,868...31,412,935
JBrowse link
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CABP1 calcium binding protein 1 ISO RGD PMID:17960496 RGD:7207144 NCBI chr14:40,563,302...40,587,975 JBrowse link
G CACNA1F calcium voltage-gated channel subunit alpha1 F involved_in ISO (PMID:27226626) UniProt PMID:27226626 NCBI chr  X:43,250,449...43,284,458
Ensembl chr  X:43,246,786...43,283,990
JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:15024042 RGD:13514097 NCBI chr 5:14,875,524...14,888,224
Ensembl chr 5:14,874,238...14,888,224
JBrowse link
G CBARP CACN subunit beta associated regulatory protein involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:21873635 PMID:24751537 RGD:10047103 NCBI chr 2:77,220,790...77,230,418
Ensembl chr 2:77,221,171...77,230,056
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 involved_in ISO (PMID:18292205) UniProt PMID:18292205 NCBI chr12:17,251,361...17,306,308
Ensembl chr12:17,252,018...17,306,319
JBrowse link
G DRD2 dopamine receptor D2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G DRD3 dopamine receptor D3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,510...145,819,173
JBrowse link
G DRD4 dopamine receptor D4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:398,766...401,539
Ensembl chr 2:398,766...401,432
JBrowse link
G FMR1 FMRP translational regulator 1 involved_in ISO PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:120,361,232...120,400,282
Ensembl chr  X:120,361,229...120,399,835
JBrowse link
G GNB5 G protein subunit beta 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:119,545,382...119,589,860
Ensembl chr 1:119,484,397...119,589,868
JBrowse link
G GPR35 G protein-coupled receptor 35 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:139,571,093...139,591,638
Ensembl chr15:139,571,086...139,591,632
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:15937148 RGD:9835002 NCBI chr17:62,905,700...62,913,018
Ensembl chr17:62,897,727...62,913,754
JBrowse link
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:95,981,820...96,375,089
Ensembl chr13:95,959,577...96,375,856
JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO RGD PMID:14679187 PMID:21943416 PMID:21943417 RGD:12910700 RGD:7242916 RGD:7243967 NCBI chr13:198,051,281...198,059,444 JBrowse link
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO RGD PMID:14679187 PMID:19219384 PMID:21943416 RGD:7242916 RGD:7243947 RGD:7243967 NCBI chr13:197,979,749...197,980,974 JBrowse link
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in ISO (PMID:22987075) RGD
BHF-UCL
PMID:14679187 PMID:22987075 RGD:7243967 NCBI chr 9:8,810,716...8,822,191
Ensembl chr 9:8,810,722...8,821,817
JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) UniProt PMID:9305853 NCBI chr 2:1,675,323...1,989,110
Ensembl chr 2:1,675,360...1,989,111
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16579
    negative regulation of biological process 5309
      negative regulation of transport 512
        negative regulation of transporter activity 86
          negative regulation of ion transmembrane transporter activity 77
            negative regulation of cation channel activity 48
              negative regulation of AMPA receptor activity 0
              negative regulation of NMDA glutamate receptor activity 3
              negative regulation of acetylcholine-gated cation channel activity 0
              negative regulation of acid-sensing ion channel activity 1
              negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
              negative regulation of large conductance calcium-activated potassium channel activity 1
              negative regulation of osmolarity-sensing cation channel activity 0
              negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
              negative regulation of ryanodine-sensitive calcium-release channel activity 10
              negative regulation of store-operated calcium channel activity 1
              negative regulation of voltage-gated calcium channel activity + 19
              negative regulation of voltage-gated potassium channel activity + 13
              negative regulation of voltage-gated sodium channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 16579
    biological regulation 12075
      regulation of biological process 11450
        regulation of localization 2875
          regulation of transport 1873
            regulation of transmembrane transport 578
              regulation of ion transmembrane transport 477
                regulation of ion transmembrane transporter activity 269
                  regulation of cation channel activity 184
                    negative regulation of cation channel activity 48
                      negative regulation of AMPA receptor activity 0
                      negative regulation of NMDA glutamate receptor activity 3
                      negative regulation of acetylcholine-gated cation channel activity 0
                      negative regulation of acid-sensing ion channel activity 1
                      negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
                      negative regulation of large conductance calcium-activated potassium channel activity 1
                      negative regulation of osmolarity-sensing cation channel activity 0
                      negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
                      negative regulation of ryanodine-sensitive calcium-release channel activity 10
                      negative regulation of store-operated calcium channel activity 1
                      negative regulation of voltage-gated calcium channel activity + 19
                      negative regulation of voltage-gated potassium channel activity + 13
                      negative regulation of voltage-gated sodium channel activity 0
paths to the root