Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cation channel activity
go back to main search page
Accession:GO:2001258 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
Synonyms:exact_synonym: negative regulation of cation diffusion facilitator activity;   negative regulation of nonselective cation channel activity


show annotations for term's descendants           Sort by:
 
negative regulation of cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 ISO RGD PMID:20624795 RGD:6849299 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655
JBrowse link
G EPO erythropoietin involved_in ISO (PMID:14569084) BHF-UCL PMID:14569084 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974
JBrowse link
G FGF12 fibroblast growth factor 12 ISO RGD PMID:12401812 RGD:6484231 NCBI chr 3:189,430,811...190,017,254
Ensembl chr 3:199,778,545...200,358,744
JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in ISO (PMID:24164424) UniProt PMID:24164424 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
negative regulation of acid-sensing ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STOML1 stomatin like 1 acts_upstream_of_or_within ISO (MGI:5619720|PMID:24247984) MGI PMID:24247984 MGI:5619720 NCBI chr15:52,892,400...52,903,812
Ensembl chr15:71,647,380...71,656,369
JBrowse link
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 involved_in ISO (MGI:5613458|PMID:23903368) UniProt PMID:23903368 MGI:5613458 NCBI chr10:56,560,589...57,269,952
Ensembl chr10:58,790,696...59,602,954
JBrowse link
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 ISO RGD PMID:8183366 PMID:8799886 RGD:61642 RGD:9743956 NCBI chr 3:153,175,465...153,594,375
Ensembl chr 3:161,402,134...161,651,524
JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 involved_in ISO (PMID:19219384) UniProt PMID:19219384 RGD:7243947 NCBI chr21:20,818,395...20,884,053 JBrowse link
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 involved_in ISO PMID:19219384
(PMID:19219384)
UniProt PMID:19219384 RGD:7243947 NCBI chr21:20,548,631...20,739,999
Ensembl chr21:34,107,443...34,107,814
Ensembl chr21:34,107,443...34,107,814
JBrowse link
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in ISO (PMID:12954870) UniProt PMID:12954870 RGD:10047250 NCBI chr11:69,527,663...69,540,236
Ensembl chr11:72,835,048...72,835,359
JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) UniProt PMID:9305853 NCBI chr11:2,469,750...2,874,467 JBrowse link
G KCNRG potassium channel regulator involved_in ISO (PMID:19968958) UniProt PMID:19968958 NCBI chr13:31,154,531...31,161,081
Ensembl chr13:49,901,696...49,908,169
JBrowse link
G MTNR1B melatonin receptor 1B ISO RGD PMID:14962062 RGD:9588668 NCBI chr11:87,996,805...88,009,865
Ensembl chr11:91,491,822...91,504,652
JBrowse link
G SUMO1 small ubiquitin like modifier 1 involved_in ISO (PMID:19223394) UniProt PMID:19223394 NCBI chr2B:89,461,773...89,493,879
Ensembl chr2B:207,613,654...207,645,590
JBrowse link
negative regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in ISO (PMID:31454269) UniProt PMID:31454269 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:31454269) UniProt PMID:31454269 NCBI chr2A:47,274,722...47,290,861
Ensembl chr2A:48,204,518...48,220,697
JBrowse link
G CALM3 calmodulin 3 involved_in ISO (PMID:31454269) UniProt PMID:31454269 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G DYSF dysferlin acts_upstream_of_or_within ISO (MGI:5545678|PMID:24302765) MGI PMID:24302765 MGI:5545678 NCBI chr2A:71,495,573...71,730,073
Ensembl chr2A:72,994,888...73,228,846
JBrowse link
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 involved_in ISO (PMID:18923542) BHF-UCL PMID:18923542 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655
JBrowse link
G SNX27 sorting nexin 27 ISO RGD PMID:21422294 RGD:8554349 NCBI chr 1:126,968,370...127,052,942
Ensembl chr 1:130,612,787...130,695,863
JBrowse link
negative regulation of large conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRBN cereblon involved_in ISO (MGI:6150698|PMID:29530986) UniProt PMID:29530986 MGI:6150698 NCBI chr 3:3,091,328...3,121,364
Ensembl chr 3:3,190,979...3,225,345
JBrowse link
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPHB2 EPH receptor B2 involved_in ISO (MGI:4867584|PMID:21113149) ARUK-UCL PMID:21113149 MGI:4867584 NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118
JBrowse link
G PARK7 Parkinsonism associated deglycase ISO RGD PMID:20698836 RGD:13463453 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
JBrowse link
G SLC6A9 solute carrier family 6 member 9 acts_upstream_of ISO (MGI:3044468|PMID:15159536) ARUK-UCL PMID:15159536 MGI:3044468 NCBI chr 1:43,298,326...43,333,345
Ensembl chr 1:44,664,839...44,704,882
JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CALM2 calmodulin 2 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr2A:47,274,722...47,290,861
Ensembl chr2A:48,204,518...48,220,697
JBrowse link
G CALM3 calmodulin 3 involved_in ISO (PMID:26164367) UniProt PMID:26164367 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CASQ2 calsequestrin 2 involved_in ISO (PMID:15041652)
PMID:17569730
(PMID:16601229)
BHF-UCL PMID:15041652 PMID:16601229 PMID:17569730 RGD:2314601 NCBI chr 1:86,795,392...86,864,196
Ensembl chr 1:121,844,097...121,913,311
JBrowse link
G CLIC2 chloride intracellular channel 2 involved_in ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738 PMID:15916532 NCBI chr  X:144,742,839...144,851,524
Ensembl chr  X:154,581,649...154,641,515
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A NOT|involved_in ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr20:1,519,330...1,548,473 JBrowse link
G FKBP1B FKBP prolyl isomerase 1B involved_in ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr2A:24,047,287...24,065,765
Ensembl chr2A:24,145,893...24,159,082
JBrowse link
G GSTM2 glutathione S-transferase mu 2 involved_in ISO (PMID:17023043), (PMID:22406107) BHF-UCL PMID:17023043 PMID:22406107 NCBI chr 1:112,043,201...112,050,810 JBrowse link
G GSTO1 glutathione S-transferase omega 1 involved_in ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel acts_upstream_of_or_within ISO (MGI:3708075|PMID:17404231) MGI PMID:17404231 MGI:3708075 NCBI chr 4:80,295,243...80,365,271
Ensembl chr 4:91,019,734...91,086,775
JBrowse link
G SRI sorcin involved_in ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr 7:80,199,719...80,214,733
Ensembl chr 7:93,850,496...93,864,029
JBrowse link
negative regulation of store-operated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBQLN1 ubiquilin 1 involved_in ISO (PMID:23307288) UniProt PMID:23307288 NCBI chr 9:41,170,416...41,218,656
Ensembl chr 9:82,597,507...82,645,587
JBrowse link
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CABP1 calcium binding protein 1 ISO RGD PMID:17960496 RGD:7207144 NCBI chr12:118,224,046...118,250,696 JBrowse link
G CACNA1F calcium voltage-gated channel subunit alpha1 F involved_in ISO (PMID:27226626) UniProt PMID:27226626 NCBI chr  X:41,504,804...41,533,501
Ensembl chr  X:49,356,994...49,385,678
JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:15024042 RGD:13514097 NCBI chr12:39,918,022...39,931,386
Ensembl chr12:40,797,293...40,811,409
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 involved_in ISO (PMID:18292205) UniProt PMID:18292205 NCBI chr17:11,261,435...11,313,630
Ensembl chr17:11,650,057...11,701,208
JBrowse link
G DRD2 dopamine receptor D2 involved_in ISO PMID:2162345
(PMID:7921596)
BHF-UCL PMID:2162345 PMID:7921596 RGD:8554169 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935
JBrowse link
G DRD4 dopamine receptor D4 involved_in ISO (PMID:7921596) BHF-UCL PMID:7921596 NCBI chr11:640,401...646,775 JBrowse link
G FMR1 FMRP translational regulator 1 involved_in ISO PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:136,937,889...136,976,828
Ensembl chr  X:147,365,748...147,405,321
JBrowse link
G GNB5 G protein subunit beta 5 involved_in ISO (PMID:11007869), (PMID:12606627) UniProt PMID:11007869 PMID:12606627 NCBI chr15:31,061,310...31,122,427
Ensembl chr15:49,388,026...49,452,123
JBrowse link
G GPR35 G protein-coupled receptor 35 involved_in ISO (PMID:17940199) UniProt PMID:17940199 NCBI chr2B:127,853,660...127,887,204
Ensembl chr2B:246,680,998...246,692,090
JBrowse link
G LOC100989336 CACN subunit beta associated regulatory protein involved_in ISO (MGI:5607190|PMID:24751537) RGD
UniProt
PMID:24751537 MGI:5607190 RGD:10047103 Ensembl chr19:1,212,854...1,220,104 JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:15937148 RGD:9835002 Ensembl chr20:62,004,176...62,017,866 JBrowse link
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 involved_in ISO (PMID:10585425) CAFA PMID:10585425 NCBI chr 3:153,175,465...153,594,375
Ensembl chr 3:161,402,134...161,651,524
JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO RGD PMID:14679187 PMID:21943416 PMID:21943417 RGD:12910700 RGD:7242916 RGD:7243967 NCBI chr21:20,818,395...20,884,053 JBrowse link
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 ISO RGD PMID:14679187 PMID:19219384 PMID:21943416 RGD:7242916 RGD:7243947 RGD:7243967 NCBI chr21:20,548,631...20,739,999
Ensembl chr21:34,107,443...34,107,814
Ensembl chr21:34,107,443...34,107,814
JBrowse link
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in ISO (PMID:22987075) RGD
BHF-UCL
PMID:14679187 PMID:22987075 RGD:7243967 NCBI chr11:69,527,663...69,540,236
Ensembl chr11:72,835,048...72,835,359
JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) UniProt PMID:9305853 NCBI chr11:2,469,750...2,874,467 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12657
    negative regulation of biological process 4827
      negative regulation of transport 504
        negative regulation of transporter activity 80
          negative regulation of ion transmembrane transporter activity 71
            negative regulation of cation channel activity 43
              negative regulation of AMPA receptor activity 0
              negative regulation of NMDA glutamate receptor activity 3
              negative regulation of acetylcholine-gated cation channel activity 0
              negative regulation of acid-sensing ion channel activity 1
              negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
              negative regulation of large conductance calcium-activated potassium channel activity 1
              negative regulation of osmolarity-sensing cation channel activity 0
              negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
              negative regulation of ryanodine-sensitive calcium-release channel activity 11
              negative regulation of store-operated calcium channel activity 1
              negative regulation of voltage-gated calcium channel activity + 15
              negative regulation of voltage-gated potassium channel activity + 11
              negative regulation of voltage-gated sodium channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 12657
    biological regulation 9218
      regulation of biological process 8712
        regulation of localization 2695
          regulation of transport 1755
            regulation of transmembrane transport 492
              regulation of ion transmembrane transport 393
                regulation of ion transmembrane transporter activity 251
                  regulation of cation channel activity 171
                    negative regulation of cation channel activity 43
                      negative regulation of AMPA receptor activity 0
                      negative regulation of NMDA glutamate receptor activity 3
                      negative regulation of acetylcholine-gated cation channel activity 0
                      negative regulation of acid-sensing ion channel activity 1
                      negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
                      negative regulation of large conductance calcium-activated potassium channel activity 1
                      negative regulation of osmolarity-sensing cation channel activity 0
                      negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
                      negative regulation of ryanodine-sensitive calcium-release channel activity 11
                      negative regulation of store-operated calcium channel activity 1
                      negative regulation of voltage-gated calcium channel activity + 15
                      negative regulation of voltage-gated potassium channel activity + 11
                      negative regulation of voltage-gated sodium channel activity 0
paths to the root