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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cation channel activity
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Accession:GO:2001258 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
Synonyms:exact_synonym: negative regulation of cation diffusion facilitator activity;   negative regulation of nonselective cation channel activity


show annotations for term's descendants           Sort by:
negative regulation of cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 IDA RGD PMID:20624795 RGD:6849299 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Epo erythropoietin involved_in ISO (PMID:14569084) RGD PMID:14569084 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Fgf12 fibroblast growth factor 12 IDA RGD PMID:12401812 RGD:6484231 NCBI chr11:71,997,049...72,564,965
Ensembl chr11:71,997,099...72,562,607 		JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO
IEA		 (PMID:24164424)
GO_REF:0000107		 RGD
Ensembl		 PMID:24164424 GO_REF:0000107 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
negative regulation of acid-sensing ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stoml1 stomatin like 1 acts_upstream_of_or_within ISO (MGI:5619720|PMID:24247984) RGD PMID:24247984 MGI:5619720 NCBI chr 8:58,661,980...58,669,860
Ensembl chr 8:58,661,992...58,669,860 		JBrowse link
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5613458|PMID:23903368)		 UniProt
RGD		 PMID:23903368 GO_REF:0000024 MGI:5613458 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300 		JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 involved_in IDA
IBA
IMP		 PMID:21873635 RGD
GO_Central		 PMID:8183366 PMID:21873635 PMID:8799886 RGD:61642, RGD:13792537, RGD:9743956 NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 involved_in IBA
IDA
ISO		 PMID:21873635
PMID:19219384
(PMID:19219384)		 RGD PMID:19219384 PMID:21873635 PMID:19219384 RGD:13792537, RGD:7243947 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 involved_in IDA
IBA
ISO		 PMID:19219384
PMID:21873635
(PMID:19219384)		 RGD PMID:19219384 PMID:19219384 PMID:21873635 RGD:7243947, RGD:13792537 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043 		JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in IBA
IDA
ISO		 PMID:21873635
PMID:12954870
(PMID:12954870)		 RGD PMID:12954870 PMID:21873635 PMID:12954870 RGD:13792537, RGD:10047250 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020 		JBrowse link
G Kcne4 potassium voltage-gated channel subfamily E regulatory subunit 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:80,243,429...80,251,533
Ensembl chr 9:80,247,379...80,250,979 		JBrowse link
G Kcne5 potassium voltage-gated channel subfamily E regulatory subunit 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:105,930,398...105,931,013
Ensembl chr  X:105,930,398...105,931,013 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) RGD PMID:9305853 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Kcnrg potassium channel regulator involved_in ISO
IBA		 (PMID:19968958)
PMID:21873635		 RGD PMID:19968958 PMID:21873635 RGD:13792537 NCBI chr15:35,774,492...35,778,818
Ensembl chr15:35,774,326...35,779,415 		JBrowse link
G Mir1 microRNA 1 involved_in ISO (PMID:23157812) RGD PMID:23157812 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir133a1 microRNA 133a-1 involved_in ISO (PMID:23157812) RGD PMID:23157812 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir1b microRNA 1b involved_in ISO (PMID:23157812) RGD PMID:23157812 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
G Mir3582 microRNA 3582 involved_in ISO (PMID:23157812) RGD PMID:23157812 NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180 		JBrowse link
G Mtnr1b melatonin receptor 1B IDA RGD PMID:14962062 RGD:9588668 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19223394)		 UniProt
RGD		 PMID:19223394 GO_REF:0000024 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761 		JBrowse link
negative regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 involved_in ISO
ISS		 (PMID:31454269)
GO_REF:0000024		 RGD
UniProt		 PMID:31454269 GO_REF:0000024 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 involved_in ISO
ISS		 (PMID:31454269)
GO_REF:0000024		 RGD
UniProt		 PMID:31454269 GO_REF:0000024 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 		JBrowse link
G Calm3 calmodulin 3 involved_in ISO
ISS		 (PMID:31454269)
GO_REF:0000024		 RGD
UniProt		 PMID:31454269 GO_REF:0000024 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Dysf dysferlin acts_upstream_of_or_within ISO MGI:3055150 (MGI:5545678|PMID:24302765) RGD PMID:24302765 MGI:5545678 NCBI chr 4:116,490,877...116,690,709
Ensembl chr 4:116,490,616...116,690,709 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222 		JBrowse link
G Rem1 RRAD and GEM like GTPase 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:141,103,722...141,112,206
Ensembl chr 3:141,103,766...141,112,203 		JBrowse link
G Rem2 RRAD and GEM like GTPase 2 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429 		JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator involved_in IEA GO_REF:0000104
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417 		JBrowse link
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 involved_in ISO (PMID:18923542) RGD PMID:18923542 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Mir212 microRNA 212 involved_in ISO (PMID:22880819) RGD PMID:22880819 NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513 		JBrowse link
G Snx27 sorting nexin 27 IDA RGD PMID:21422294 RGD:8554349 NCBI chr 2:182,135,904...182,218,906
Ensembl chr 2:182,135,905...182,218,906 		JBrowse link
negative regulation of large conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crbn cereblon involved_in ISO (MGI:6150698|PMID:29530986) RGD PMID:29530986 MGI:6150698 NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938 		JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 involved_in ISO
ISS		 (PMID:26164367)
GO_REF:0000024		 RGD
UniProt		 PMID:26164367 GO_REF:0000024 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 involved_in ISO
ISS		 (PMID:26164367)
GO_REF:0000024		 RGD
UniProt		 PMID:26164367 GO_REF:0000024 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 		JBrowse link
G Calm3 calmodulin 3 involved_in ISO
ISS		 (PMID:26164367)
GO_REF:0000024		 RGD
UniProt		 PMID:26164367 GO_REF:0000024 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Casq2 calsequestrin 2 involved_in ISO
IMP		 (PMID:16601229)
PMID:17569730
(PMID:15041652)		 RGD PMID:15041652 PMID:16601229 PMID:17569730 RGD:2314601 NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267 		JBrowse link
G Clic2 chloride intracellular channel 2 involved_in ISO (PMID:15147738), (PMID:15916532) RGD PMID:15147738 PMID:15916532 NCBI chr20:149,337...164,375
Ensembl chr20:148,907...164,355 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT|involved_in ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B involved_in ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 involved_in ISO (PMID:17023043), (PMID:22406107) RGD PMID:17023043 PMID:22406107 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 involved_in ISO
IEA		 (PMID:11035031)
GO_REF:0000107		 RGD
Ensembl		 PMID:11035031 GO_REF:0000107 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel acts_upstream_of_or_within ISO (MGI:3708075|PMID:17404231) RGD PMID:17404231 MGI:3708075 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Sri sorcin involved_in ISO (PMID:17699613) RGD PMID:17699613 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077 		JBrowse link
negative regulation of store-operated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ubqln1 ubiquilin 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23307288)		 UniProt
Ensembl
RGD		 PMID:23307288 GO_REF:0000024 GO_REF:0000107 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cabp1 calcium binding protein 1 IDA RGD PMID:17960496 RGD:7207144 NCBI chr12:41,385,234...41,448,930
Ensembl chr12:41,378,897...41,448,927 		JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F involved_in ISO (PMID:27226626) RGD PMID:27226626 NCBI chr  X:14,868,096...14,896,413
Ensembl chr  X:14,868,024...14,896,413 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IDA RGD PMID:15024042 RGD:13514097 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074 		JBrowse link
G Cbarp CACN subunit beta associated regulatory protein involved_in IMP
ISO		 (MGI:5607190|PMID:24751537) RGD PMID:24751537 PMID:24751537 MGI:5607190, RGD:10047103 NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:9,566,364...9,575,204 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 involved_in ISO (PMID:18292205) RGD PMID:18292205 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Drd2 dopamine receptor D2 involved_in IDA
ISO		 PMID:2162345
(PMID:7921596)		 RGD PMID:7921596 PMID:2162345 RGD:8554169 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd4 dopamine receptor D4 involved_in ISO
IEA		 (PMID:7921596)
GO_REF:0000107		 RGD
Ensembl		 PMID:7921596 GO_REF:0000107 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in IMP PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Gnb5 G protein subunit beta 5 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:11007869), (PMID:12606627)		 CAFA
Ensembl
RGD		 PMID:11007869 PMID:12606627 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:76,076,227...76,104,151
Ensembl chr 8:76,073,306...76,105,069 		JBrowse link
G Gpr35 G protein-coupled receptor 35 involved_in ISO (PMID:17940199) RGD PMID:17940199 NCBI chr 9:93,526,691...93,539,302
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 IMP RGD PMID:26584289 RGD:155804278 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mir200c microRNA 200c involved_in ISO (PMID:29373717) RGD PMID:29373717 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mir208a microRNA 208a involved_in ISO (PMID:27545043) RGD PMID:27545043 NCBI chr15:28,425,570...28,425,652 JBrowse link
G Mir208b microRNA 208b involved_in ISO (PMID:27545043) RGD PMID:27545043 NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:15937148 RGD:9835002 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grp gastrin releasing peptide involved_in IDA PMID:33059246 UniProt PMID:33059246 RGD:151356648 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061 		JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 involved_in ISO (PMID:10585425) RGD PMID:10585425 NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 IDA RGD PMID:14679187 PMID:21943416 PMID:21943417 RGD:7243967, RGD:7242916, RGD:12910700 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 IDA RGD PMID:19219384 PMID:21943416 PMID:14679187 RGD:7243947, RGD:7242916, RGD:7243967 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043 		JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in IDA
ISO		 (PMID:22987075) RGD PMID:22987075 PMID:14679187 RGD:7243967 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:9305853) RGD PMID:9305853 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Mir103a1 microRNA 103a-1 involved_in ISO (PMID:27558843) RGD PMID:27558843 NCBI chr10:20,244,412...20,244,497
Ensembl chr10:20,244,412...20,244,497 		JBrowse link
G Mir103a2 microRNA 103a-2 involved_in ISO (PMID:27558843) RGD PMID:27558843 NCBI chr 3:118,510,194...118,510,279
Ensembl chr 3:118,510,194...118,510,279 		JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:31553627) RGD PMID:31553627 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:31553627) RGD PMID:31553627 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir30d microRNA 30d involved_in ISO (PMID:27180889) RGD PMID:27180889 NCBI chr 7:100,136,391...100,136,472
Ensembl chr 7:100,136,391...100,136,472 		JBrowse link
negative regulation of voltage-gated sodium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grp gastrin releasing peptide involved_in IDA PMID:33059246 UniProt PMID:33059246 RGD:151356648 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061 		JBrowse link
G Mir192 microRNA 192 involved_in ISO UniProtKB:Q14524 (PMID:26209011) RGD PMID:26209011 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055 		JBrowse link
G Mir24-2 microRNA 24-2 involved_in ISO (PMID:29457789) RGD PMID:29457789 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790 		JBrowse link
G Mir448 microRNA 448 involved_in ISO (PMID:33108349) RGD PMID:33108349 NCBI chr  X:110,829,918...110,830,029
Ensembl chr  X:110,829,918...110,830,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    negative regulation of biological process 5824
      negative regulation of transport 595
        negative regulation of transporter activity 129
          negative regulation of ion transmembrane transporter activity 103
            negative regulation of cation channel activity 65
              negative regulation of acetylcholine-gated cation channel activity 0
              negative regulation of acid-sensing ion channel activity 1
              negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
              negative regulation of large conductance calcium-activated potassium channel activity 1
              negative regulation of osmolarity-sensing cation channel activity 0
              negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
              negative regulation of ryanodine-sensitive calcium-release channel activity 12
              negative regulation of store-operated calcium channel activity 1
              negative regulation of voltage-gated calcium channel activity + 23
              negative regulation of voltage-gated potassium channel activity + 24
              negative regulation of voltage-gated sodium channel activity 4
Path 2
Term Annotations click to browse term
  biological_process 19746
    localization 5598
      establishment of localization 4939
        transport 4766
          regulation of transport 2066
            regulation of transmembrane transport 672
              regulation of transmembrane transporter activity 319
                regulation of monoatomic ion transmembrane transporter activity 307
                  negative regulation of ion transmembrane transporter activity 103
                    negative regulation of cation channel activity 65
                      negative regulation of acetylcholine-gated cation channel activity 0
                      negative regulation of acid-sensing ion channel activity 1
                      negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
                      negative regulation of large conductance calcium-activated potassium channel activity 1
                      negative regulation of osmolarity-sensing cation channel activity 0
                      negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
                      negative regulation of ryanodine-sensitive calcium-release channel activity 12
                      negative regulation of store-operated calcium channel activity 1
                      negative regulation of voltage-gated calcium channel activity + 23
                      negative regulation of voltage-gated potassium channel activity + 24
                      negative regulation of voltage-gated sodium channel activity 4
paths to the root