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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cation channel activity
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Accession:GO:2001257 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cation channel activity.
Synonyms:exact_synonym: regulation of cation diffusion facilitator activity;   regulation of nonselective cation channel activity


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activation of store-operated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STIM1 stromal interaction molecule 1 ISO RGD PMID:21541286 RGD:7175076 NCBI chr11:3,726,501...3,954,951
Ensembl chr11:3,840,513...4,065,224 		JBrowse link
G STIM2 stromal interaction molecule 2 ISO RGD PMID:21541286 RGD:7175076 NCBI chr 4:21,262,272...21,424,944
Ensembl chr 4:26,537,703...26,694,416 		JBrowse link
negative regulation of cation channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 ISO RGD PMID:20624795 RGD:6849299 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G FGF12 fibroblast growth factor 12 ISO RGD PMID:12401812 RGD:6484231 NCBI chr 3:189,430,811...190,017,254
Ensembl chr 3:199,778,545...200,358,744 		JBrowse link
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNAB1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 ISO RGD PMID:8183366 PMID:8799886 RGD:61642 RGD:9743956 NCBI chr 3:153,175,465...153,594,375
Ensembl chr 3:161,402,134...161,651,524 		JBrowse link
G MTNR1B melatonin receptor 1B ISO RGD PMID:14962062 RGD:9588668 NCBI chr11:87,996,805...88,009,865
Ensembl chr11:91,491,822...91,504,652 		JBrowse link
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNX27 sorting nexin 27 ISO RGD PMID:21422294 RGD:8554349 NCBI chr 1:126,968,370...127,052,942
Ensembl chr 1:130,612,787...130,695,863 		JBrowse link
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CABP1 calcium binding protein 1 ISO RGD PMID:17960496 RGD:7207144 NCBI chr12:118,224,046...118,250,696 JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:15024042 RGD:13514097 NCBI chr12:39,918,022...39,931,386
Ensembl chr12:40,797,293...40,811,409 		JBrowse link
G CBARP CACN subunit beta associated regulatory protein ISO RGD PMID:24751537 RGD:10047103 Ensembl chr19:1,212,854...1,220,104 JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO RGD PMID:26584289 RGD:155804278 NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:15937148 RGD:9835002 Ensembl chr20:62,004,176...62,017,866 JBrowse link
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO RGD PMID:14679187 PMID:21943416 PMID:21943417 RGD:12910700 RGD:7242916 RGD:7243967 NCBI chr21:20,818,395...20,884,053
Ensembl chr21:34,190,043...34,190,441 		JBrowse link
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 ISO RGD PMID:14679187 RGD:7243967 NCBI chr11:69,527,663...69,540,236
Ensembl chr11:72,835,048...72,835,359 		JBrowse link
G LOC106634235 uncharacterized LOC106634235 ISO RGD PMID:14679187 PMID:19219384 PMID:21943416 RGD:7242916 RGD:7243947 RGD:7243967 NCBI chr21:20,548,631...20,739,999
Ensembl chr21:34,107,443...34,107,814
Ensembl chr21:34,107,443...34,107,814 		JBrowse link
positive regulation of cation channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 ISO RGD PMID:22505670 RGD:6893581 NCBI chr10:110,642,491...110,646,595 JBrowse link
G ASIC2 acid sensing ion channel subunit 2 ISO RGD PMID:12736332 RGD:1298620 NCBI chr17:22,628,322...23,774,249 JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:20806410 RGD:9686372 NCBI chr 5:64,673,392...65,116,259
Ensembl chr 5:69,724,767...70,158,761 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 ISO RGD PMID:23785408 RGD:7296920 NCBI chr11:17,440,522...17,444,075
Ensembl chr11:17,127,557...17,128,729 		JBrowse link
G NTSR1 neurotensin receptor 1 ISO RGD PMID:19359367 RGD:9743912 NCBI chr20:59,100,110...59,151,563
Ensembl chr20:60,392,736...60,446,056 		JBrowse link
positive regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:22187436 RGD:13514092 NCBI chr12:39,918,022...39,931,386
Ensembl chr12:40,797,293...40,811,409 		JBrowse link
positive regulation of large conductance calcium-activated potassium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKG1 protein kinase cGMP-dependent 1 ISO RGD PMID:23407708 RGD:7777099 NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882 		JBrowse link
positive regulation of store-operated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 ISO RGD PMID:20844246 RGD:8801954 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752 		JBrowse link
positive regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO RGD PMID:20478999 RGD:13514093 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482 		JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:15024042 RGD:13514097 NCBI chr12:39,918,022...39,931,386
Ensembl chr12:40,797,293...40,811,409 		JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:12821675 RGD:737839 NCBI chr2B:39,137,777...39,399,007
Ensembl chr2B:156,379,469...156,639,328 		JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO RGD PMID:14679187 RGD:7243967 NCBI chr21:20,818,395...20,884,053
Ensembl chr21:34,190,043...34,190,441 		JBrowse link
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 ISO RGD PMID:14679187 RGD:7243967 NCBI chr11:69,527,663...69,540,236
Ensembl chr11:72,835,048...72,835,359 		JBrowse link
G LOC106634235 uncharacterized LOC106634235 ISO RGD PMID:14679187 RGD:7243967 NCBI chr21:20,548,631...20,739,999
Ensembl chr21:34,107,443...34,107,814
Ensembl chr21:34,107,443...34,107,814 		JBrowse link
G S100A1 S100 calcium binding protein A1 ISO RGD PMID:19657060 RGD:7205633 NCBI chr 1:128,984,296...128,987,979 JBrowse link
positive regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO RGD PMID:12183335 RGD:728122 NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870 		JBrowse link
G AMIGO1 adhesion molecule with Ig like domain 1 ISO RGD PMID:22056818 RGD:14390155 NCBI chr 1:111,881,753...111,887,308
Ensembl chr 1:111,113,632...111,115,113 		JBrowse link
G KCNA1 potassium voltage-gated channel subfamily A member 1 ISO RGD PMID:21943416 RGD:7242916 NCBI chr12:5,027,333...5,037,136
Ensembl chr12:4,950,938...4,952,425 		JBrowse link
G KCNC1 potassium voltage-gated channel subfamily C member 1 ISO RGD PMID:21943417 RGD:12910700 NCBI chr11:17,788,010...17,936,591
Ensembl chr11:17,472,158...17,517,892 		JBrowse link
G KCNC2 potassium voltage-gated channel subfamily C member 2 ISO RGD PMID:21943417 RGD:12910700 NCBI chr12:72,566,924...72,736,270 JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO RGD PMID:7568179 RGD:12910723 NCBI chr21:20,818,395...20,884,053
Ensembl chr21:34,190,043...34,190,441 		JBrowse link
G KCNK3 potassium two pore domain channel subfamily K member 3 ISO RGD PMID:31347976 RGD:151347452 NCBI chr2A:26,688,938...26,729,860
Ensembl chr2A:26,780,475...26,819,123 		JBrowse link
positive regulation of voltage-gated sodium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPER1 G protein-coupled estrogen receptor 1 ISO RGD PMID:24097558 RGD:39939085 NCBI chr 7:1,331,586...1,338,194 JBrowse link
G KIF5B kinesin family member 5B ISO RGD PMID:24198377 RGD:11073607 NCBI chr10:32,138,964...32,186,448
Ensembl chr10:32,731,150...32,778,242 		JBrowse link
regulation of acetylcholine-gated cation channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit ISO RGD PMID:11904236 RGD:704387 NCBI chr20:59,730,759...59,748,678
Ensembl chr20:61,270,631...61,283,005 		JBrowse link
regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 ISO RGD PMID:18322004 RGD:7207845 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135 		JBrowse link
G CALM2 calmodulin 2 ISO RGD PMID:18322004 RGD:7207845 NCBI chr2A:47,274,722...47,290,861
Ensembl chr2A:48,204,518...48,220,697 		JBrowse link
G CALM3 calmodulin 3 ISO RGD PMID:18322004 RGD:7207845 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135 		JBrowse link
regulation of kainate selective glutamate receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRIP1 glutamate receptor interacting protein 1 ISO RGD PMID:12597860 RGD:152995391 NCBI chr12:21,841,611...22,562,418
Ensembl chr12:22,744,177...23,069,480 		JBrowse link
G POLR2F RNA polymerase II, I and III subunit F ISO RGD PMID:12597860 RGD:152995391 NCBI chr22:18,868,872...18,988,918
Ensembl chr22:36,796,015...36,814,469 		JBrowse link
regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 ISO RGD PMID:15628869 RGD:7241270 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135 		JBrowse link
G CALM2 calmodulin 2 ISO RGD PMID:15628869 RGD:7241270 NCBI chr2A:47,274,722...47,290,861
Ensembl chr2A:48,204,518...48,220,697 		JBrowse link
G CALM3 calmodulin 3 ISO RGD PMID:15628869 RGD:7241270 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135 		JBrowse link
regulation of store-operated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G6 phospholipase A2 group VI ISO RGD PMID:12547829 RGD:6482757 NCBI chr22:18,998,060...19,094,507
Ensembl chr22:36,849,794...36,919,509
Ensembl chr22:36,849,794...36,919,509 		JBrowse link
G PLCG1 phospholipase C gamma 1 ISO RGD PMID:17432954 RGD:2299884 NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145 		JBrowse link
regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CABP1 calcium binding protein 1 ISO RGD PMID:17224447 RGD:7207146 NCBI chr12:118,224,046...118,250,696 JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A ISO RGD PMID:17196942 RGD:1598976 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 ISO RGD PMID:12042350 RGD:632406 NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    cellular process 15499
      transmembrane transport 1475
        monoatomic ion transmembrane transport 937
          regulation of monoatomic ion transmembrane transport 286
            regulation of monoatomic cation transmembrane transport 251
              regulation of cation channel activity 43
                negative regulation of cation channel activity + 13
                positive regulation of cation channel activity + 24
                regulation of acetylcholine-gated cation channel activity + 1
                regulation of delayed rectifier potassium channel activity + 2
                regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity + 0
                regulation of inward rectifier potassium channel activity + 1
                regulation of kainate selective glutamate receptor activity 2
                regulation of large conductance calcium-activated potassium channel activity + 1
                regulation of osmolarity-sensing cation channel activity + 0
                regulation of proton-transporting ATP synthase activity, rotational mechanism + 0
                regulation of ryanodine-sensitive calcium-release channel activity + 3
                regulation of store-operated calcium channel activity + 5
                regulation of voltage-gated calcium channel activity + 16
                regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization + 0
                regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization + 0
                regulation of voltage-gated sodium channel activity + 2
Path 2
Term Annotations click to browse term
  biological_process 16440
    localization 5279
      establishment of localization 4578
        transport 4266
          transmembrane transport 1475
            monoatomic ion transmembrane transport 937
              monoatomic cation transmembrane transport 784
                regulation of monoatomic cation transmembrane transport 251
                  regulation of cation channel activity 43
                    negative regulation of cation channel activity + 13
                    positive regulation of cation channel activity + 24
                    regulation of acetylcholine-gated cation channel activity + 1
                    regulation of delayed rectifier potassium channel activity + 2
                    regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity + 0
                    regulation of inward rectifier potassium channel activity + 1
                    regulation of kainate selective glutamate receptor activity 2
                    regulation of large conductance calcium-activated potassium channel activity + 1
                    regulation of osmolarity-sensing cation channel activity + 0
                    regulation of proton-transporting ATP synthase activity, rotational mechanism + 0
                    regulation of ryanodine-sensitive calcium-release channel activity + 3
                    regulation of store-operated calcium channel activity + 5
                    regulation of voltage-gated calcium channel activity + 16
                    regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization + 0
                    regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization + 0
                    regulation of voltage-gated sodium channel activity + 2
paths to the root