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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of apoptotic signaling pathway
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Accession:GO:2001235 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
Synonyms:exact_synonym: positive regulation of apoptotic signalling pathway
 never_in_taxon: NCBITaxon:4896 ! Schizosaccharomyces pombe


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positive regulation of apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10845921) Ensembl
MGI		 PMID:10845921 GO_REF:0000107 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16183742) Ensembl
MGI		 PMID:16183742 GO_REF:0000107 NCBI chr12:96,224,515...96,311,246
Ensembl chr12:99,637,622...99,726,939 		JBrowse link
G BID BH3 interacting domain death agonist involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8918887) Ensembl
MGI		 PMID:8918887 GO_REF:0000107 NCBI chr22:1,164,787...1,205,051
Ensembl chr22:16,594,186...16,632,844 		JBrowse link
G BMF Bcl2 modifying factor acts_upstream_of_or_within ISO (PMID:11546872) MGI PMID:11546872 NCBI chr15:19,026,053...19,047,008
Ensembl chr15:37,281,655...37,302,075 		JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:17367784) MGI PMID:17367784 NCBI chr 7:44,930,859...45,040,078
Ensembl chr 7:45,001,267...45,110,342 		JBrowse link
G CASP2 caspase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16183742) Ensembl
MGI
TreeGrafter		 PMID:16183742 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:135,283,072...135,307,855
Ensembl chr 7:147,773,749...147,792,958 		JBrowse link
G CASP9 caspase 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266 		JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain acts_upstream_of_or_within ISO (PMID:16183742) MGI PMID:16183742 NCBI chr12:91,220,813...91,593,799 JBrowse link
G CTSC cathepsin C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20435891) Ensembl
MGI		 PMID:20435891 GO_REF:0000107 NCBI chr11:83,299,827...83,345,383
Ensembl chr11:86,890,010...86,933,847 		JBrowse link
G CTSH cathepsin H involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20435891) Ensembl
MGI		 PMID:20435891 GO_REF:0000107 NCBI chr15:57,893,379...57,917,194
Ensembl chr15:76,852,668...76,876,976 		JBrowse link
G CTSL cathepsin L involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:58,851,899...58,857,170
Ensembl chr 9:86,903,006...86,908,303 		JBrowse link
G CTSS cathepsin S involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:126,084,249...126,118,221
Ensembl chr 1:129,733,996...129,768,318 		JBrowse link
G CTSV cathepsin V involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:68,119,453...68,129,522
Ensembl chr 9:96,240,690...96,249,708 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336 		JBrowse link
G DAXX death domain associated protein acts_upstream_of_or_within ISO (PMID:10684855) MGI PMID:10684855 NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717 		JBrowse link
G EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15680327) Ensembl
MGI		 PMID:15680327 GO_REF:0000107 NCBI chr 6:7,911,807...7,940,918
Ensembl chr 6:8,192,997...8,222,056 		JBrowse link
G FAS Fas cell surface death receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G IFNB1 interferon beta 1 involved_in ISO (PMID:10918594), (PMID:11337497) UniProt PMID:10918594 PMID:11337497 NCBI chr 9:20,884,742...20,886,317 JBrowse link
G IL19 interleukin 19 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12370360) Ensembl
MGI		 PMID:12370360 GO_REF:0000107 NCBI chr 1:182,372,339...182,446,147
Ensembl chr 1:186,651,640...186,724,748 		JBrowse link
G INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21750715) Ensembl
MGI		 PMID:21750715 GO_REF:0000107 NCBI chr17:5,036,659...5,046,146
Ensembl chr17:5,024,740...5,034,216 		JBrowse link
G ING5 inhibitor of growth family member 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21750715) Ensembl
MGI
TreeGrafter		 PMID:21750715 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:128,979,282...129,007,476
Ensembl chr2B:247,755,552...247,793,893 		JBrowse link
G INHBB inhibin subunit beta B acts_upstream_of_or_within ISO (PMID:20454446) MGI PMID:20454446 NCBI chr2B:7,278,944...7,284,632 JBrowse link
G JAK2 Janus kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15012602) Ensembl
MGI		 PMID:15012602 GO_REF:0000107 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G MAGED1 MAGE family member D1 acts_upstream_of_or_within ISO (PMID:17488777)
(PMID:19268530)		 MGI PMID:17488777 PMID:19268530 NCBI chr  X:43,999,576...44,098,848
Ensembl chr  X:51,984,080...51,992,850 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 acts_upstream_of_or_within ISO (PMID:16458303) MGI PMID:16458303 NCBI chr10:45,806,748...45,936,362 JBrowse link
G MAPK9 mitogen-activated protein kinase 9 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16458303) Ensembl
MGI		 PMID:16458303 GO_REF:0000107 NCBI chr 5:175,437,167...175,495,469
Ensembl chr 5:182,748,381...182,795,135 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor acts_upstream_of_or_within ISO (PMID:14517295) MGI PMID:14517295 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863 		JBrowse link
G NFATC4 nuclear factor of activated T cells 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20530871) Ensembl
MGI		 PMID:20530871 GO_REF:0000107 NCBI chr14:5,141,699...5,156,021
Ensembl chr14:23,266,702...23,279,249 		JBrowse link
G NGFR nerve growth factor receptor acts_upstream_of_or_within ISO (PMID:10764727) MGI PMID:10764727 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NKX3-1 NK3 homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:22,926,145...22,930,396
Ensembl chr 8:19,863,275...19,864,942 		JBrowse link
G OSM oncostatin M acts_upstream_of_or_within ISO (PMID:15012602) MGI PMID:15012602 NCBI chr22:11,298,965...11,303,009
Ensembl chr22:29,101,085...29,105,081 		JBrowse link
G PDCD7 programmed cell death 7 acts_upstream_of_or_within ISO (PMID:10037816) MGI PMID:10037816 NCBI chr15:44,057,667...44,073,812 JBrowse link
G PML PML nuclear body scaffold acts_upstream_of_or_within ISO (PMID:10684855) MGI PMID:10684855 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883 		JBrowse link
G PRKCD protein kinase C delta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15731106) Ensembl
MGI		 PMID:15731106 GO_REF:0000107 NCBI chr 3:53,104,137...53,135,588
Ensembl chr 3:54,330,328...54,357,910 		JBrowse link
G PTEN phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:9778245) MGI PMID:9778245 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G RPP21 ribonuclease P/MRP subunit p21 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:30,122,996...30,124,784
Ensembl chr 6:30,975,260...30,995,764 		JBrowse link
G RPS3 ribosomal protein S3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:70,460,702...70,466,909
Ensembl chr11:73,762,794...73,768,982 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748 		JBrowse link
G TP63 tumor protein p63 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9774969) Ensembl
MGI		 PMID:9774969 GO_REF:0000107 NCBI chr 3:186,651,879...186,918,300
Ensembl chr 3:195,199,167...195,474,104 		JBrowse link
G TP73 tumor protein p73 acts_upstream_of_or_within ISO (PMID:16044147) MGI PMID:16044147 NCBI chr 1:2,323,399...2,405,295
Ensembl chr 1:3,476,064...3,529,206 		JBrowse link
G TPD52L1 TPD52 like 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:122,943,780...123,053,201
Ensembl chr 6:127,062,573...127,172,174 		JBrowse link
G TRAF7 TNF receptor associated factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:1,013,831...1,036,486
Ensembl chr16:2,266,194...2,279,031 		JBrowse link
G TRIM39 tripartite motif containing 39 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:30,104,381...30,121,649
Ensembl chr 6:30,975,260...30,995,764 		JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:55,396,279...55,418,579
Ensembl chr 3:56,621,380...56,638,051 		JBrowse link
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:128,832,458...128,847,918
Ensembl chr2B:247,626,494...247,640,238 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:22240901) MGI PMID:22240901 NCBI chr2A:87,688,732...87,759,580
Ensembl chr2A:89,596,833...89,667,468 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:133,902,463...133,990,414
Ensembl chr 3:141,427,870...141,451,444 		JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:95,939,197...96,089,163
Ensembl chr2A:106,898,547...106,976,363 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570 		JBrowse link
G RNF183 ring finger protein 183 involved_in ISO (PMID:29507230) UniProt PMID:29507230 NCBI chr 9:84,396,738...84,404,057 JBrowse link
G SERINC3 serine incorporator 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12486168) Ensembl
MGI		 PMID:12486168 GO_REF:0000107 NCBI chr20:40,827,299...40,852,028
Ensembl chr20:41,921,639...41,946,287 		JBrowse link
G SIRT1 sirtuin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069 		JBrowse link
G SPOP speckle type BTB/POZ protein acts_upstream_of_or_within ISO (PMID:20811152) MGI PMID:20811152 NCBI chr17:43,685,913...43,765,277
Ensembl chr17:48,417,634...48,440,623 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044 		JBrowse link
G AGTR2 angiotensin II receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:105,252,903...105,257,171
Ensembl chr  X:115,671,594...115,672,685 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G BCL10 BCL10 immune signaling adaptor involved_in
acts_upstream_of_or_within		 ISO (PMID:11466612)
(PMID:10753917)		 UniProt
MGI		 PMID:10753917 PMID:11466612 NCBI chr 1:117,823,388...117,834,314 JBrowse link
G BCL2L14 BCL2 like 14 involved_in ISO (PMID:11054413) UniProt PMID:11054413 NCBI chr12:12,072,021...12,122,015
Ensembl chr12:12,444,839...12,492,777 		JBrowse link
G BID BH3 interacting domain death agonist involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr22:1,164,787...1,205,051
Ensembl chr22:16,594,186...16,632,844 		JBrowse link
G CASP8 caspase 8 acts_upstream_of_or_within ISO (PMID:16183742) MGI PMID:16183742 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G DEDD2 death effector domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:39,086,735...39,108,312
Ensembl chr19:47,678,915...47,700,431 		JBrowse link
G FADD Fas associated via death domain involved_in
acts_upstream_of_or_within		 ISO (PMID:21525013)
(PMID:22675671)		 UniProt
MGI		 PMID:21525013 PMID:22675671 NCBI chr11:65,300,889...65,305,020 JBrowse link
G G0S2 G0/G1 switch 2 involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:185,251,903...185,252,882
Ensembl chr 1:190,057,382...190,057,693 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 involved_in ISO PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chr 7:1,331,586...1,338,194 JBrowse link
G HYAL2 hyaluronidase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19366691) Ensembl
MGI		 PMID:19366691 GO_REF:0000107 NCBI chr 3:50,243,926...50,248,972
Ensembl chr 3:51,479,020...51,482,551 		JBrowse link
G ITM2C integral membrane protein 2C involved_in ISO (MGI:4821078|PMID:14592447) UniProt PMID:14592447 MGI:4821078 NCBI chr2B:118,116,228...118,131,379 JBrowse link
G LTBR lymphotoxin beta receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:6,514,432...6,521,966
Ensembl chr12:6,422,470...6,438,510 		JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:194,084,037...194,174,010
Ensembl chr 3:204,023,357...204,111,507 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 acts_upstream_of_or_within ISO (PMID:15858817) MGI PMID:15858817 NCBI chr15:22,706,520...22,731,672
Ensembl chr15:40,794,144...40,821,763 		JBrowse link
G PML PML nuclear body scaffold involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8666928) Ensembl
MGI		 PMID:8666928 GO_REF:0000107 NCBI chr 1:174,246,389...174,364,893
Ensembl chr 1:178,556,104...178,672,994 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,764,386...23,765,732
Ensembl chr16:31,571,363...31,573,828 		JBrowse link
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19136968) Ensembl
MGI		 PMID:19136968 GO_REF:0000107 NCBI chr20:615,987...639,366
Ensembl chr20:386,569...409,580 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19498109) Ensembl
MGI		 PMID:19498109 GO_REF:0000107 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
G RUNX3 RUNX family transcription factor 3 acts_upstream_of_or_within ISO (PMID:11955451) MGI PMID:11955451 NCBI chr 1:24,097,321...24,164,065
Ensembl chr 1:25,073,134...25,137,335 		JBrowse link
G SFRP1 secreted frizzled related protein 1 acts_upstream_of_or_within ISO (PMID:14976225) MGI PMID:14976225 NCBI chr 8:40,507,027...40,555,053 JBrowse link
G SIGLEC1 sialic acid binding Ig like lectin 1 acts_upstream_of_or_within ISO (PMID:23408841) MGI PMID:23408841 NCBI chr20:3,769,118...3,795,678
Ensembl chr20:3,526,791...3,552,309 		JBrowse link
G TLR4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chr 4:33,153,151...33,174,053
Ensembl chr 4:39,009,103...39,011,490 		JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:1,962,179...1,964,223
Ensembl chr16:3,134,577...3,136,581 		JBrowse link
G TNFSF10 TNF superfamily member 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15632112) Ensembl
MGI		 PMID:15632112 GO_REF:0000107 NCBI chr 3:169,512,491...169,530,706
Ensembl chr 3:177,694,021...177,712,137 		JBrowse link
G TNFSF12 TNF superfamily member 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,581,163...7,589,809
Ensembl chr17:7,567,766...7,575,575 		JBrowse link
G TRAF2 TNF receptor associated factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:107,938,935...107,984,797
Ensembl chr 9:136,917,358...136,955,331 		JBrowse link
G WWOX WW domain containing oxidoreductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:58,689,609...59,800,333
Ensembl chr16:78,125,302...79,231,546 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNA1 catenin alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22411810) Ensembl
MGI		 PMID:22411810 GO_REF:0000107 NCBI chr 5:134,134,944...134,313,239
Ensembl chr 5:140,261,883...140,438,547 		JBrowse link
G DAPK3 death associated protein kinase 3 involved_in ISO PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chr19:2,984,806...2,996,782
Ensembl chr19:3,934,496...3,946,011 		JBrowse link
G HTRA2 HtrA serine peptidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:74,596,020...74,599,790
Ensembl chr2A:76,102,240...76,106,152 		JBrowse link
G INHBA inhibin subunit beta A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,538,591...42,556,578
Ensembl chr 7:42,580,730...42,595,097 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G NF1 neurofibromin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15039234) Ensembl
MGI		 PMID:15039234 GO_REF:0000107 NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295 		JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12115603) Ensembl
MGI		 PMID:12115603 GO_REF:0000107 NCBI chr11:62,756,659...62,760,369
Ensembl chr11:66,068,007...66,071,611 		JBrowse link
G PPP2R1A protein phosphatase 2 scaffold subunit Aalpha acts_upstream_of_or_within ISO (PMID:12944463) MGI PMID:12944463 NCBI chr19:49,133,295...49,169,447
Ensembl chr19:58,011,383...58,047,577 		JBrowse link
G PPP2R1B protein phosphatase 2 scaffold subunit Abeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:106,609,754...106,651,811
Ensembl chr11:110,465,475...110,495,908 		JBrowse link
G RET ret proto-oncogene involved_in ISO (PMID:10921886) UniProt PMID:10921886 NCBI chr10:40,050,396...40,103,629
Ensembl chr10:43,249,468...43,284,331 		JBrowse link
G SRPX sushi repeat containing protein X-linked involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17088259) Ensembl
MGI		 PMID:17088259 GO_REF:0000107 NCBI chr  X:30,598,574...30,670,464
Ensembl chr  X:38,303,313...38,378,770 		JBrowse link
G TGFB2 transforming growth factor beta 2 acts_upstream_of_or_within ISO (PMID:8206089) MGI PMID:8206089 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041 		JBrowse link
G UNC5B unc-5 netrin receptor B involved_in ISO PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chr10:67,682,415...67,772,760
Ensembl chr10:70,207,998...70,298,038 		JBrowse link
G WWOX WW domain containing oxidoreductase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19366691) Ensembl
MGI		 PMID:19366691 GO_REF:0000107 NCBI chr16:58,689,609...59,800,333
Ensembl chr16:78,125,302...79,231,546 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1B bone morphogenetic protein receptor type 1B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18363966) Ensembl
MGI		 PMID:18363966 GO_REF:0000107 NCBI chr 4:87,125,911...87,523,084
Ensembl chr 4:98,088,072...98,195,848 		JBrowse link
G FAF1 Fas associated factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8524870) Ensembl
MGI		 PMID:8524870 GO_REF:0000107 NCBI chr 1:49,679,198...50,207,129
Ensembl chr 1:51,188,540...51,606,904 		JBrowse link
G LOC100979315 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15705586) BHF-UCL PMID:15705586 NCBI chr18:53,286,590...53,290,913
Ensembl chr18:56,611,098...56,615,449 		JBrowse link
G MAL mal, T cell differentiation protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12776198) Ensembl
MGI		 PMID:12776198 GO_REF:0000107 NCBI chr2A:104,355,020...104,382,849
Ensembl chr2A:95,930,315...95,956,573 		JBrowse link
G PEA15 proliferation and apoptosis adaptor protein 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10588860) Ensembl
MGI		 PMID:10588860 GO_REF:0000107 NCBI chr 1:135,559,273...135,569,392
Ensembl chr 1:139,480,394...139,490,503 		JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (PMID:8940094) MGI PMID:8940094 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in ISO (PMID:9391078) BHF-UCL PMID:9391078 NCBI chr 8:40,507,027...40,555,053 JBrowse link
G SKIL SKI like proto-oncogene involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10811619) Ensembl
MGI		 PMID:10811619 GO_REF:0000107 NCBI chr 3:167,372,104...167,411,287
Ensembl chr 3:175,562,007...175,600,181 		JBrowse link
G STK3 serine/threonine kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20080598) Ensembl
MGI		 PMID:20080598 GO_REF:0000107 NCBI chr 8:95,098,185...95,465,324
Ensembl chr 8:97,355,173...97,708,437 		JBrowse link
G STK4 serine/threonine kinase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20080598) Ensembl
MGI		 PMID:20080598 GO_REF:0000107 NCBI chr20:41,297,157...41,410,487
Ensembl chr20:42,389,615...42,503,014 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170 		JBrowse link
G TRPS1 transcriptional repressor GATA binding 1 acts_upstream_of_or_within ISO (PMID:18363966) MGI PMID:18363966 NCBI chr 8:112,079,147...112,339,567 JBrowse link
G ZSWIM2 zinc finger SWIM-type containing 2 acts_upstream_of_or_within ISO (PMID:16522193) MGI PMID:16522193 NCBI chr2B:74,120,669...74,142,560 JBrowse link
positive regulation of intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO MMO:0000679 RGD PMID:23729662 RGD:329403056 NCBI chr 1:143,239,576...143,404,038
Ensembl chr 1:147,023,671...147,129,705 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14502238) Ensembl
MGI		 PMID:14502238 GO_REF:0000107 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
G BBC3 BCL2 binding component 3 involved_in ISO (PMID:17289999), (PMID:27031958) UniProt PMID:17289999 PMID:27031958 RGD:14390051 NCBI chr19:44,203,517...44,215,860 JBrowse link
G BCAP31 B cell receptor associated protein 31 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:143,265,920...143,274,956
Ensembl chr  X:153,137,992...153,161,628 		JBrowse link
G BCL2L11 BCL2 like 11 involved_in ISO (PMID:21671007) UniProt PMID:21671007 NCBI chr2A:90,862,070...90,909,833
Ensembl chr2A:112,337,927...112,385,079 		JBrowse link
G BCLAF1 BCL2 associated transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:134,023,195...134,054,507
Ensembl chr 6:138,115,451...138,137,108 		JBrowse link
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G BID BH3 interacting domain death agonist involved_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr22:1,164,787...1,205,051
Ensembl chr22:16,594,186...16,632,844 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:128,832,458...128,847,918
Ensembl chr2B:247,626,494...247,640,238 		JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase acts_upstream_of_or_within ISO (PMID:17938250) MGI PMID:17938250 NCBI chr2A:91,393,317...91,433,579
Ensembl chr2A:111,793,236...111,858,392 		JBrowse link
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CLU clusterin involved_in ISO (PMID:21567405) UniProt PMID:21567405 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 involved_in ISO (PMID:27031958) UniProt PMID:27031958 NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701 		JBrowse link
G DNM1L dynamin 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:53,476,553...53,541,421
Ensembl chr12:56,077,504...56,142,376 		JBrowse link
G EI24 EI24 autophagy associated transmembrane protein acts_upstream_of_or_within ISO (PMID:17981155) MGI PMID:17981155 NCBI chr11:120,389,136...120,404,347
Ensembl chr11:124,302,289...124,317,346 		JBrowse link
G FIS1 fission, mitochondrial 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:93,381,058...93,386,483
Ensembl chr 7:106,621,211...106,626,683 		JBrowse link
G FLCN folliculin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21258407) Ensembl
MGI		 PMID:21258407 GO_REF:0000107 NCBI chr17:34,057,127...34,081,637
Ensembl chr17:38,988,518...39,013,160 		JBrowse link
G GSDME gasdermin E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,373,485...25,433,001
Ensembl chr 7:24,977,838...25,039,525 		JBrowse link
G IL19 interleukin 19 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23468852) Ensembl
MGI		 PMID:23468852 GO_REF:0000107 NCBI chr 1:182,372,339...182,446,147
Ensembl chr 1:186,651,640...186,724,748 		JBrowse link
G IL20RA interleukin 20 receptor subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23468852) Ensembl
MGI		 PMID:23468852 GO_REF:0000107 NCBI chr 6:134,762,355...134,805,937
Ensembl chr 6:138,848,400...138,866,098 		JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:31,560,229...31,572,391
Ensembl chr 1:32,565,739...32,579,923 		JBrowse link
G LOC100979315 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:21454712) UniProt PMID:21454712 NCBI chr18:53,286,590...53,290,913
Ensembl chr18:56,611,098...56,615,449 		JBrowse link
G LOC100988353 septin-4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:52,595,185...52,607,020
Ensembl chr17:57,448,904...57,472,690 		JBrowse link
G LOC129392969 DDIT3 upstream open reading frame protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr12:31,664,743...31,668,701 JBrowse link
G NHERF1 NHERF family PDZ scaffold protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:68,694,468...68,715,157
Ensembl chr17:74,250,406...74,271,234 		JBrowse link
G NKX3-1 NK3 homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:22,926,145...22,930,396
Ensembl chr 8:19,863,275...19,864,942 		JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:29,015,155...29,016,987 JBrowse link
G PLAGL2 PLAG1 like zinc finger 2 acts_upstream_of_or_within ISO (PMID:11832486) MGI PMID:11832486 NCBI chr20:28,481,605...28,496,903
Ensembl chr20:29,610,196...29,625,442 		JBrowse link
G PLEKHF1 pleckstrin homology and FYVE domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16188880) TreeGrafter
MGI		 PMID:16188880 GO_REF:0000118 NCBI chr19:26,593,833...26,604,514 JBrowse link
G PRKRA protein activator of interferon induced protein kinase EIF2AK2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12181197) Ensembl
MGI		 PMID:12181197 GO_REF:0000107 NCBI chr2B:65,689,029...65,708,493
Ensembl chr2B:183,393,819...183,413,174 		JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:176,462,991...176,470,153
Ensembl chr 5:183,712,665...183,720,128 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490590) Ensembl
MGI		 PMID:10490590 GO_REF:0000107 NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821 		JBrowse link
G S100A8 S100 calcium binding protein A8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:128,741,378...128,742,520
Ensembl chr 1:132,370,435...132,371,591 		JBrowse link
G S100A9 S100 calcium binding protein A9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:128,709,175...128,712,461
Ensembl chr 1:132,338,246...132,341,497 		JBrowse link
G SIAH1 siah E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:28,627,021...28,651,343
Ensembl chr16:47,517,594...47,522,936 		JBrowse link
G STYXL1 serine/threonine/tyrosine interacting like 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:67,973,316...68,024,986
Ensembl chr 7:82,446,562...82,497,769 		JBrowse link
G TAF6 TATA-box binding protein associated factor 6 involved_in ISO (PMID:20096117) UniProt PMID:20096117 NCBI chr 7:92,142,646...92,154,951
Ensembl chr 7:105,575,861...105,588,142 		JBrowse link
G TP53 tumor protein p53 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF5A eukaryotic translation initiation factor 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,341,076...7,346,570
Ensembl chr17:7,327,363...7,333,270 		JBrowse link
G MSX1 msh homeobox 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 4:4,935,600...4,939,079 JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863 		JBrowse link
G RPS7 ribosomal protein S7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:3,593,350...3,599,106
Ensembl chr2A:3,512,079...3,517,785 		JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 involved_in ISO (MGI:5553386|PMID:24523556) UniProt PMID:24523556 MGI:5553386 NCBI chr 1:119,224,304...119,267,986
Ensembl chr 1:88,077,420...88,121,056 		JBrowse link
G UBB ubiquitin B acts_upstream_of_or_within ISO (PMID:17571083) MGI PMID:17571083 NCBI chr17:35,286,699...35,288,429 JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBH1 F-box DNA helicase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23361013) MGI
Ensembl		 PMID:23361013 GO_REF:0000107 NCBI chr10:5,931,389...5,978,844
Ensembl chr10:5,915,713...5,962,778 		JBrowse link
G MTCH2 mitochondrial carrier 2 acts_upstream_of_or_within ISO (PMID:26219591) MGI PMID:26219591 NCBI chr11:47,566,884...47,596,711
Ensembl chr11:48,115,774...48,146,312 		JBrowse link
G NACC2 NACC family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:107,079,113...107,168,332
Ensembl chr 9:136,066,229...136,105,176 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16816390) Ensembl
MGI		 PMID:16816390 GO_REF:0000107 NCBI chr19:3,030,885...3,062,642
Ensembl chr19:3,982,555...4,015,167 		JBrowse link
G PLSCR1 phospholipid scramblase 1 acts_upstream_of_or_within ISO (PMID:12509439) MGI PMID:12509439 NCBI chr 3:143,528,967...143,558,468
Ensembl chr 3:151,112,483...151,132,964 		JBrowse link
G RAD9A RAD9 checkpoint clamp component A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15983387) Ensembl
MGI		 PMID:15983387 GO_REF:0000107 NCBI chr11:62,675,480...62,756,886
Ensembl chr11:66,061,208...66,068,214 		JBrowse link
G RPS3 ribosomal protein S3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:70,460,702...70,466,909
Ensembl chr11:73,762,794...73,768,982 		JBrowse link
G SKIL SKI like proto-oncogene involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10811619) Ensembl
MGI		 PMID:10811619 GO_REF:0000107 NCBI chr 3:167,372,104...167,411,287
Ensembl chr 3:175,562,007...175,600,181 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100977427 large ribosomal subunit protein uL24 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:56,616,749...56,617,299
Ensembl chr17:48,009,198...48,015,977 		JBrowse link
G RPL26 ribosomal protein L26 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,274,839...43,282,606
Ensembl chr17:48,009,198...48,015,977 		JBrowse link
G STEAP3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:18617898) MGI PMID:18617898 NCBI chr2B:6,166,296...6,208,338
Ensembl chr2B:119,752,363...119,787,051 		JBrowse link
G TP73 tumor protein p73 acts_upstream_of_or_within ISO (PMID:15983387) MGI PMID:15983387 NCBI chr 1:2,323,399...2,405,295
Ensembl chr 1:3,476,064...3,529,206 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257 		JBrowse link
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOX1 NADPH oxidase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19661248) Ensembl
MGI		 PMID:19661248 GO_REF:0000107 NCBI chr  X:90,046,023...90,076,968
Ensembl chr  X:100,182,398...100,215,192 		JBrowse link
G PARK7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (PMID:22555455) MGI PMID:22555455 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271 		JBrowse link
G SFPQ splicing factor proline and glutamine rich involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:34,444,105...34,461,012
Ensembl chr 1:35,632,917...35,641,551 		JBrowse link
G SOD1 superoxide dismutase 1 involved_in ISO (PMID:12551919) BHF-UCL PMID:12551919 NCBI chr21:18,029,831...18,037,526 JBrowse link
G VNN1 vanin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:130,459,268...130,491,167
Ensembl chr 6:134,566,117...134,598,784 		JBrowse link
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:28386847 RGD:329337357 NCBI chr 1:143,239,576...143,404,038
Ensembl chr 1:147,023,671...147,129,705 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:125,918,760...125,923,952
Ensembl chr 1:129,566,827...129,572,086 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:27614125 RGD:329961568 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G RALBP1 ralA binding protein 1 ISO RGD PMID:23788031 RGD:12904719 NCBI chr18:4,747,555...4,810,710
Ensembl chr18:7,028,188...7,090,934 		JBrowse link
positive regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF3 activating transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:188,176,728...188,188,842
Ensembl chr 1:193,036,793...193,049,150 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    cellular process 15397
      signal transduction 5399
        positive regulation of signal transduction 1628
          positive regulation of apoptotic signaling pathway 166
            positive regulation of extrinsic apoptotic signaling pathway + 59
            positive regulation of intrinsic apoptotic signaling pathway + 74
Path 2
Term Annotations click to browse term
  biological_process 16313
    biological regulation 11327
      regulation of biological process 10982
        signaling 5900
          signal transduction 5399
            regulation of signal transduction 2984
              positive regulation of signal transduction 1628
                positive regulation of apoptotic signaling pathway 166
                  positive regulation of extrinsic apoptotic signaling pathway + 59
                  positive regulation of intrinsic apoptotic signaling pathway + 74
paths to the root