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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cellular senescence
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Accession:GO:2000772 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cellular senescence.

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regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:22729085) MGI PMID:22729085 NCBI chrNW_004955513:652,048...799,182
Ensembl chrNW_004955513:653,252...799,239 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 involved_in ISO (MGI:5554364|PMID:22101268) UniProt PMID:22101268 MGI:5554364 NCBI chrNW_004955414:28,652,663...28,748,360
Ensembl chrNW_004955414:28,684,226...28,748,360 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO (PMID:22729085) MGI PMID:22729085 NCBI chrNW_004955510:5,812,571...5,936,312
Ensembl chrNW_004955510:5,905,008...5,936,312 		JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase acts_upstream_of_or_within ISO (PMID:23686339) MGI PMID:23686339 NCBI chrNW_004955486:6,280,838...6,289,584
Ensembl chrNW_004955486:6,280,125...6,289,584 		JBrowse link
G Nek4 NIMA related kinase 4 involved_in ISO (PMID:22851694) UniProt PMID:22851694 NCBI chrNW_004955430:2,695,674...2,733,204
Ensembl chrNW_004955430:2,696,493...2,733,392 		JBrowse link
G Nuak1 NUAK family kinase 1 involved_in ISO (PMID:19927127) UniProt PMID:19927127 NCBI chrNW_004955405:40,156,316...40,188,144
Ensembl chrNW_004955405:40,153,747...40,188,145 		JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 involved_in ISO (PMID:16055741) UniProt PMID:16055741 NCBI chrNW_004955424:27,407,451...27,449,830
Ensembl chrNW_004955424:27,407,489...27,448,992 		JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 involved_in ISO (PMID:18678645) UniProt PMID:18678645 NCBI chrNW_004955442:6,749,038...6,764,461
Ensembl chrNW_004955442:6,748,267...6,764,650 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO (PMID:23695662) MGI PMID:23695662 NCBI chrNW_004955543:258,479...271,128
Ensembl chrNW_004955543:258,479...272,473 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:22904064) MGI PMID:22904064 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
G Vash1 vasohibin 1 acts_upstream_of_or_within ISO (PMID:23056314) MGI PMID:23056314 NCBI chrNW_004955438:753,392...772,937
Ensembl chrNW_004955438:752,554...772,937 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO (PMID:16079796), (PMID:21746928)
(PMID:23686339)		 MGI PMID:16079796 PMID:21746928 PMID:23686339 NCBI chrNW_004955537:82,724...134,609
Ensembl chrNW_004955537:81,920...134,609 		JBrowse link
G Znf277 zinc finger protein 277 acts_upstream_of_or_within ISO (PMID:20808772) MGI PMID:20808772 NCBI chrNW_004955410:15,971,524...16,083,482
Ensembl chrNW_004955410:15,971,513...16,083,482 		JBrowse link
negative regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:22729085) MGI PMID:22729085 NCBI chrNW_004955513:652,048...799,182
Ensembl chrNW_004955513:653,252...799,239 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 involved_in ISO (PMID:25323119) BHF-UCL PMID:25323119 NCBI chrNW_004955406:6,907,876...7,163,672 JBrowse link
G Bcl2l12 BCL2 like 12 acts_upstream_of_or_within ISO (PMID:20837658) MGI PMID:20837658 NCBI chrNW_004955559:1,217,797...1,224,875
Ensembl chrNW_004955559:1,217,809...1,224,875 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:23209284) MGI PMID:23209284 NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259 		JBrowse link
G Cdk6 cyclin dependent kinase 6 involved_in ISO (PMID:17420273) UniProt PMID:17420273 NCBI chrNW_004955432:9,521,794...9,727,772
Ensembl chrNW_004955432:9,521,794...9,726,417 		JBrowse link
G Fbxo5 F-box protein 5 involved_in ISO (PMID:17875940) UniProt PMID:17875940 NCBI chrNW_004955439:8,830,658...8,843,653
Ensembl chrNW_004955439:8,830,975...8,843,828 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO (MGI:5009768|PMID:21241890) BHF-UCL PMID:21241890 MGI:5009768 NCBI chrNW_004955495:5,481,914...5,503,690
Ensembl chrNW_004955495:5,481,916...5,505,521 		JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO RGD PMID:30690003 RGD:401717569 NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614 		JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO (MGI:5582375|PMID:23072816) BHF-UCL PMID:23072816 MGI:5582375 NCBI chrNW_004955458:12,493,790...12,624,805 JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 involved_in ISO (PMID:28640956) BHF-UCL PMID:28640956 NCBI chrNW_004955478:8,122,999...8,185,138
Ensembl chrNW_004955478:8,125,436...8,199,253 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:10562313) BHF-UCL PMID:10562313 NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO RGD PMID:28125705 RGD:13781884 NCBI chrNW_004955410:10,717,664...10,742,109
Ensembl chrNW_004955410:10,717,664...10,751,177 		JBrowse link
G Plk2 polo like kinase 2 involved_in ISO (MGI:6120300|PMID:27908889) BHF-UCL PMID:27908889 MGI:6120300 NCBI chrNW_004955446:9,671,090...9,676,956
Ensembl chrNW_004955446:9,671,090...9,677,188 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO RGD PMID:22981234 RGD:8696027 NCBI chrNW_004955454:7,733,697...7,890,896
Ensembl chrNW_004955454:7,733,978...7,890,867 		JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (MGI:5009768|PMID:21241890) BHF-UCL PMID:21241890 MGI:5009768 NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 involved_in ISO (PMID:28595801) BHF-UCL PMID:28595801 NCBI chrNW_004955422:24,620,068...24,695,203
Ensembl chrNW_004955422:24,620,078...24,695,229 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:20203304)
(PMID:20424141)		 AgBase
BHF-UCL
UniProt		 PMID:20203304 PMID:20424141 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663 		JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:29474172)
(PMID:22753495), (PMID:27043296)		 UniProt PMID:22753495 PMID:27043296 PMID:29474172 NCBI chrNW_004955495:4,641,883...4,650,518
Ensembl chrNW_004955495:4,644,023...4,650,083 		JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO (PMID:12000749)
(PMID:11062467)		 UniProt PMID:11062467 PMID:12000749 NCBI chrNW_004955451:2,458,612...2,466,264
Ensembl chrNW_004955451:2,457,568...2,466,639 		JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:11927518) BHF-UCL PMID:11927518 NCBI chrNW_004955484:7,318,813...7,344,221
Ensembl chrNW_004955484:7,318,860...7,347,430 		JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO (PMID:11927518)
(PMID:11313459)		 BHF-UCL PMID:11313459 PMID:11927518 NCBI chrNW_004955504:649,248...669,796
Ensembl chrNW_004955504:651,779...670,589 		JBrowse link
G Tp63 tumor protein p63 involved_in ISO (PMID:19451233) UniProt PMID:19451233 NCBI chrNW_004955420:18,178,639...18,384,786
Ensembl chrNW_004955420:18,176,155...18,384,786 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) BHF-UCL PMID:17690110 NCBI chrNW_004955410:22,003,981...22,005,483 JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:16501043) BHF-UCL PMID:16501043 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167 		JBrowse link
G Ybx1 Y-box binding protein 1 involved_in ISO (MGI:6158172|PMID:29712925) UniProt PMID:29712925 MGI:6158172 NCBI chrNW_004955537:2,234,052...2,254,528
Ensembl chrNW_004955537:2,234,054...2,251,708 		JBrowse link
positive regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3 ABI family member 3 involved_in ISO (PMID:21223585) ARUK-UCL PMID:21223585 NCBI chrNW_004955451:12,241,084...12,248,857 JBrowse link
G Arg2 arginase 2 involved_in ISO (PMID:22928666) UniProt PMID:22928666 NCBI chrNW_004955466:2,549,557...2,577,060
Ensembl chrNW_004955466:2,549,557...2,577,060 		JBrowse link
G B2m beta-2-microglobulin involved_in ISO (PMID:28213472) ARUK-UCL PMID:28213472 NCBI chrNW_004955416:11,205,503...11,211,325
Ensembl chrNW_004955416:11,204,849...11,215,568 		JBrowse link
G Ccn1 cellular communication network factor 1 ISO RGD PMID:30371213 RGD:329845516 NCBI chrNW_004955423:8,416,498...8,419,029
Ensembl chrNW_004955423:8,413,725...8,419,166 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (MGI:5909142|PMID:28759028) UniProt PMID:28759028 MGI:5909142 NCBI chrNW_004955493:8,593,104...8,607,297 JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 involved_in ISO (PMID:25465621) BHF-UCL PMID:25465621 NCBI chrNW_004955465:5,878,055...5,895,232
Ensembl chrNW_004955465:5,878,058...5,895,223 		JBrowse link
G Ilk integrin linked kinase ISO RGD PMID:17234816 RGD:2301768 NCBI chrNW_004955414:22,316,243...22,322,979
Ensembl chrNW_004955414:22,316,047...22,322,979 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:17706954 RGD:11060281 NCBI chrNW_004955413:20,298,852...20,328,756
Ensembl chrNW_004955413:20,298,824...20,328,758 		JBrowse link
G Morc3 MORC family CW-type zinc finger 3 acts_upstream_of_or_within ISO (PMID:17332504) MGI PMID:17332504 NCBI chrNW_004955407:35,548,219...35,599,543
Ensembl chrNW_004955407:35,548,219...35,599,543 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:19698731 RGD:10003167 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694 		JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in ISO (MGI:5648604|PMID:25472717) BHF-UCL PMID:25472717 MGI:5648604 NCBI chrNW_004955405:18,434,711...18,540,710
Ensembl chrNW_004955405:18,434,711...18,540,710 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:18687677) UniProt PMID:18687677 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663 		JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:20203304) AgBase PMID:20203304 NCBI chrNW_004955495:6,678,195...6,699,408
Ensembl chrNW_004955495:6,678,195...6,699,058 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO (MGI:5142390|PMID:10562313)
(PMID:17053789)
(PMID:29474172)		 BHF-UCL
MGI
UniProt		 PMID:10562313 PMID:17053789 PMID:29474172 MGI:5142390 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
G Ypel3 yippee like 3 involved_in ISO (PMID:20388804) HGNC PMID:20388804 NCBI chrNW_004955493:6,885,050...6,888,729
Ensembl chrNW_004955493:6,885,052...6,888,729 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12321
    metabolic process 7441
      regulation of metabolic process 4798
        regulation of cellular metabolic process 4416
          regulation of cellular senescence 50
            negative regulation of cellular senescence 25
            positive regulation of cellular senescence 15
Path 2
Term Annotations click to browse term
  biological_process 12321
    biological regulation 8863
      regulation of biological process 8603
        regulation of metabolic process 4798
          regulation of cellular metabolic process 4416
            regulation of cellular senescence 50
              negative regulation of cellular senescence 25
              positive regulation of cellular senescence 15
paths to the root