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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cellular senescence
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Accession:GO:2000772 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cellular senescence.



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regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:1338938 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like involved_in ISS
ISO
GO_REF:0000024
(MGI:5554364|PMID:22101268)
UniProt
RGD
PMID:22101268 GO_REF:0000024 MGI:5554364 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:87859 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase acts_upstream_of_or_within ISO MGI:1890508 (MGI:5500993|PMID:23686339) RGD PMID:23686339 MGI:5500993 NCBI chr 5:162,804,368...162,811,129
Ensembl chr 5:162,804,368...162,811,128
JBrowse link
G Ing2 inhibitor of growth family, member 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482
JBrowse link
G Nek4 NIMA-related kinase 4 involved_in ISO (PMID:22851694) RGD PMID:22851694 NCBI chr16:6,144,900...6,185,376
Ensembl chr16:6,144,959...6,188,932
JBrowse link
G Nuak1 NUAK family kinase 1 involved_in ISO (PMID:19927127) RGD PMID:19927127 NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913
JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 involved_in ISO (PMID:16055741) RGD PMID:16055741 NCBI chr14:102,877,553...102,908,696
Ensembl chr14:102,877,553...102,908,696
JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 involved_in ISO (PMID:18678645) RGD PMID:18678645 NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593
JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO MGI:2445449 (MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:5913114 NCBI chr  X:14,421,028...14,434,216
Ensembl chr  X:14,421,109...14,433,982
JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 acts_upstream_of_or_within ISO MGI:2445449 (MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:5913114 NCBI chr  X:141,793,695...141,795,558 JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:2139971 (MGI:5504576|PMID:22904064) RGD PMID:22904064 MGI:5504576 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vash1 vasohibin 1 acts_upstream_of_or_within ISO (PMID:23056314) RGD PMID:23056314 NCBI chr 6:106,330,374...106,345,740
Ensembl chr 6:106,329,123...106,345,726
JBrowse link
G Zfp277 zinc finger protein 277 acts_upstream_of_or_within ISO MGI:5496522 (MGI:5496352|PMID:20808772) RGD PMID:20808772 MGI:5496352 NCBI chr 6:57,383,944...57,512,785
Ensembl chr 6:57,383,951...57,512,765
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO MGI:1888594|MGI:2180033 (MGI:3789238|PMID:16079796), (MGI:5139938|PMID:21746928), (MGI:5500993|PMID:23686339) RGD PMID:16079796 PMID:21746928 PMID:23686339 MGI:3789238 MGI:5139938 MGI:5500993 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110
JBrowse link
negative regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:104738 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Akt3 AKT serine/threonine kinase 3 involved_in ISO
IEA
(PMID:25323119)
GO_REF:0000107
RGD
Ensembl
PMID:25323119 GO_REF:0000107 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Bcl2l12 Bcl2-like 12 acts_upstream_of_or_within ISO (MGI:4834958|PMID:20837658) RGD PMID:20837658 MGI:4834958 NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991
JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158436 (MGI:5469797|PMID:23209284) RGD PMID:23209284 MGI:5469797 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Cdk6 cyclin-dependent kinase 6 involved_in ISO (PMID:17420273) RGD PMID:17420273 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Fbxo5 F-box protein 5 involved_in ISO (PMID:17875940) RGD PMID:17875940 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO
IEA
(MGI:5009768|PMID:21241890)
GO_REF:0000107
RGD
Ensembl
PMID:21241890 GO_REF:0000107 MGI:5009768 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO (MGI:5582375|PMID:23072816) RGD PMID:23072816 MGI:5582375 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G LOC100912427 nuclease-sensitive element-binding protein 1-like involved_in ISO (MGI:6158172|PMID:29712925) RGD PMID:29712925 MGI:6158172 NCBI chr 1:171,304,587...171,306,092
Ensembl chr 1:171,304,774...171,306,097
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 involved_in ISO (PMID:28640956) RGD PMID:28640956 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:10562313) RGD PMID:10562313 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IDA RGD PMID:28125705 RGD:13781884 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Plk2 polo-like kinase 2 involved_in ISO (MGI:6120300|PMID:27908889) RGD PMID:27908889 MGI:6120300 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (MGI:5009768|PMID:21241890) RGD PMID:21241890 MGI:5009768 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 involved_in ISO
IEA
(PMID:28595801)
GO_REF:0000107
RGD
Ensembl
PMID:28595801 GO_REF:0000107 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:20203304), (PMID:20424141) RGD PMID:20203304 PMID:20424141 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:22753495), (PMID:27043296), (PMID:29474172) RGD PMID:22753495 PMID:27043296 PMID:29474172 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
JBrowse link
G Slc30a10 solute carrier family 30, member 10 involved_in ISO (PMID:22427991) RGD PMID:22427991 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO (PMID:11062467), (PMID:12000749) RGD PMID:11062467 PMID:12000749 NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529
JBrowse link
G Terc telomerase RNA component involved_in ISO (PMID:11313459) RGD PMID:11313459 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Terf2 telomeric repeat binding factor 2 involved_in ISO (PMID:11927518) RGD PMID:11927518 NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819
JBrowse link
G Tert telomerase reverse transcriptase involved_in ISO (PMID:11313459), (PMID:11927518) RGD PMID:11313459 PMID:11927518 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tp63 tumor protein p63 involved_in ISO (PMID:19451233) RGD PMID:19451233 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO
IEA
(PMID:16501043)
GO_REF:0000107
RGD
Ensembl
PMID:16501043 GO_REF:0000107 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Ybx1 Y box binding protein 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:6158172|PMID:29712925)
UniProt
Ensembl
RGD
PMID:29712925 GO_REF:0000024 GO_REF:0000107 MGI:6158172 NCBI chr 5:132,882,137...132,899,108
Ensembl chr 5:132,882,145...132,898,862
JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 involved_in ISO (PMID:23434374) RGD PMID:23434374 NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827
JBrowse link
positive regulation of cellular senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3 ABI family, member 3 involved_in ISO (PMID:21223585) RGD PMID:21223585 NCBI chr10:80,769,819...80,780,816
Ensembl chr10:80,769,822...80,780,816
JBrowse link
G Abi3bp ABI family member 3 binding protein involved_in ISS GO_REF:0000024 ARUK-UCL GO_REF:0000024 NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929
JBrowse link
G Arg2 arginase 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:22928666)
Ensembl
RGD
PMID:22928666 GO_REF:0000107 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G B2m beta-2 microglobulin involved_in ISO (PMID:28213472) RGD PMID:28213472 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (MGI:5909142|PMID:28759028) RGD PMID:28759028 MGI:5909142 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 involved_in ISO (PMID:25465621) RGD PMID:25465621 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720
JBrowse link
G Ilk integrin-linked kinase IMP RGD PMID:17234816 RGD:2301768 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Kras KRAS proto-oncogene, GTPase IMP RGD PMID:17706954 RGD:11060281 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mir188 microRNA 188 involved_in ISO (PMID:28640956) RGD PMID:28640956 NCBI chr  X:15,247,715...15,247,794
Ensembl chr  X:15,247,715...15,247,794
JBrowse link
G Mir20b microRNA 20b involved_in ISO (PMID:28595801) RGD PMID:28595801 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282
JBrowse link
G Mir217 microRNA 217 involved_in ISO (PMID:19786632) RGD PMID:19786632 NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609
JBrowse link
G Mir22 microRNA 22 involved_in ISO (PMID:25323119) RGD PMID:25323119 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:20424141) RGD PMID:20424141 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
JBrowse link
G Morc3 MORC family CW-type zinc finger 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17332504)
GO_REF:0000107
RGD
Ensembl
PMID:17332504 GO_REF:0000107 NCBI chr11:33,151,906...33,194,646
Ensembl chr11:33,152,025...33,194,646
JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:19698731 RGD:10003167 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in ISO (MGI:5648604|PMID:25472717) RGD PMID:25472717 MGI:5648604 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:23184984) RGD PMID:23184984 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:18687677) RGD PMID:18687677 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO (PMID:20203304) RGD PMID:20203304 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in
ISO MGI:1920086 (MGI:3692019|PMID:17053789)
(MGI:5142390|PMID:10562313)
RGD PMID:10562313 PMID:17053789 MGI:3692019 MGI:5142390 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ypel3 yippee-like 3 involved_in ISO (PMID:20388804) RGD PMID:20388804 NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18872
    metabolic process 11588
      regulation of metabolic process 6786
        regulation of cellular metabolic process 5528
          regulation of cellular senescence 61
            negative regulation of cellular senescence 28
            positive regulation of cellular senescence 21
Path 2
Term Annotations click to browse term
  biological_process 18872
    biological regulation 13378
      regulation of biological process 12642
        regulation of metabolic process 6786
          regulation of cellular metabolic process 5528
            regulation of cellular senescence 61
              negative regulation of cellular senescence 28
              positive regulation of cellular senescence 21
paths to the root