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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of reactive oxygen species metabolic process
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Accession:GO:2000379 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
Synonyms:exact_synonym: positive regulation of ROS metabolic process;   positive regulation of reactive oxygen species metabolism


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positive regulation of reactive oxygen species metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) RGD PMID:23609450 MGI:5490396 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529
JBrowse link
G Ager advanced glycosylation end product-specific receptor IMP RGD PMID:19885844 RGD:7244243 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO (PMID:19442656) RGD PMID:19442656 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Cbr1 carbonyl reductase 1 involved_in ISO (PMID:19442656) RGD PMID:19442656 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cd36 CD36 molecule involved_in ISO (MGI:4850200|PMID:20978343) RGD PMID:20978343 MGI:4850200 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:20160708) RGD PMID:20160708 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 IMP RGD PMID:20439821 RGD:7829726 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase involved_in ISO (PMID:19442656) RGD PMID:19442656 NCBI chr10:106,006,404...106,008,294 JBrowse link
G Dhrs4 dehydrogenase/reductase 4 involved_in ISO (PMID:19442656) RGD PMID:19442656 NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127
JBrowse link
G Duoxa1 dual oxidase maturation factor 1 acts_upstream_of_or_within ISO MGI:2139422 (MGI:4833934|PMID:20233719) RGD PMID:20233719 MGI:4833934 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A IMP RGD PMID:20930373 RGD:10395362 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G F2 coagulation factor II involved_in IEA
ISO
GO_REF:0000107
(PMID:17275676)
Ensembl
RGD
PMID:17275676 GO_REF:0000107 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha involved_in IEA
ISO
GO_REF:0000107
(PMID:20160708)
Ensembl
RGD
PMID:20160708 GO_REF:0000107 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Grb2 growth factor receptor bound protein 2 involved_in ISO (PMID:20160708) RGD PMID:20160708 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Lcn2 lipocalin 2 IMP RGD PMID:30574656 RGD:126781752 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lep leptin IDA RGD PMID:20738325 RGD:8693628 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in ISO
IEA
(PMID:20160708)
GO_REF:0000107
RGD
Ensembl
PMID:20160708 GO_REF:0000107 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 involved_in ISO (MGI:4850200|PMID:20978343) RGD PMID:20978343 MGI:4850200 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nox1 NADPH oxidase 1 IMP RGD PMID:16254042 RGD:1581408 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 IMP RGD PMID:15848200 RGD:2324674 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 IMP RGD PMID:23554738 RGD:11073697 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:19019919)
Ensembl
UniProt
RGD
PMID:19019919 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta involved_in ISS
ISO
GO_REF:0000024
(MGI:5284758|PMID:19019919)
UniProt
RGD
PMID:19019919 GO_REF:0000024 MGI:5284758 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 involved_in ISO (PMID:20165904) RGD PMID:20165904 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Plau plasminogen activator, urokinase IDA RGD PMID:16456094 RGD:6484217 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:15158121 RGD:1642626 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in
acts_upstream_of_or_within
ISO (MGI:5315337|PMID:21052097)
(MGI:5510543|PMID:19498109)
RGD PMID:19498109 PMID:21052097 MGI:5315337 MGI:5510543 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rnf41 ring finger protein 41 involved_in ISO (PMID:18541373) RGD PMID:18541373 NCBI chr 7:838,160...876,869
Ensembl chr 7:838,203...865,511
JBrowse link
G Romo1 reactive oxygen species modulator 1 involved_in ISO (PMID:16842742) RGD PMID:16842742 NCBI chr 3:144,659,709...144,661,310
Ensembl chr 3:144,659,826...144,661,310
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO (PMID:20160708) RGD PMID:20160708 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:18757424) RGD PMID:18757424 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tp53 tumor protein p53 involved_in ISO (PMID:20160708) RGD PMID:20160708 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tspo translocator protein involved_in IDA
ISO
(MGI:5689082|PMID:25470454) RGD PMID:25470454 PMID:12437594 MGI:5689082, RGD:2317161 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Xdh xanthine dehydrogenase involved_in IEA
ISO
GO_REF:0000107
(PMID:18386220)
Ensembl
RGD
PMID:18386220 GO_REF:0000107 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISO (PMID:22739135) RGD PMID:22739135 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
positive regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Duoxa1 dual oxidase maturation factor 1 involved_in ISO (PMID:22814254) RGD PMID:22814254 NCBI chr 3:109,249,815...109,260,511
Ensembl chr 3:109,249,923...109,260,499
JBrowse link
G Duoxa2 dual oxidase maturation factor 2 involved_in ISO (PMID:16651268), (PMID:22814254) RGD PMID:16651268 PMID:22814254 NCBI chr 3:109,245,476...109,248,844
Ensembl chr 3:109,245,476...109,248,968
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IMP RGD PMID:19306371 RGD:13506652 Ensembl chr MT:7,006...7,689 JBrowse link
G Sod2 superoxide dismutase 2 IMP RGD PMID:20529999 RGD:27095884 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,615,470...12,623,615
Ensembl chr10:12,615,190...12,623,615
JBrowse link
positive regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nnt nicotinamide nucleotide transhydrogenase IMP RGD PMID:24722990 RGD:13513981 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:23507046) RGD PMID:23507046 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
positive regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrb1 adhesion G protein-coupled receptor B1 involved_in ISO (PMID:26838550) RGD PMID:26838550 NCBI chr 7:106,404,844...106,476,902
Ensembl chr 7:106,404,958...106,476,902
JBrowse link
G Cd36 CD36 molecule involved_in ISO (MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:4438693 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Clcn3 chloride voltage-gated channel 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2447864 (MGI:3663198|PMID:16522634)
Ensembl
RGD
PMID:16522634 GO_REF:0000107 MGI:3663198 NCBI chr16:29,127,419...29,200,133
Ensembl chr16:29,127,419...29,200,119
JBrowse link
G Cyba cytochrome b-245 alpha chain involved_in ISO (PMID:22423966) RGD PMID:22423966 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Foxo3 forkhead box O3 IMP RGD PMID:24278276 RGD:10402204 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 involved_in IGI PMID:17308309 ARUK-UCL PMID:17308309 RGD:12910994 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Hdac4 histone deacetylase 4 IMP RGD PMID:24166750 RGD:9681442 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Il4 interleukin 4 IDA RGD PMID:24073824 RGD:10402792 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Lcn2 lipocalin 2 IDA RGD PMID:25557118 RGD:126790477 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:27997345 RGD:12910740 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in ISO
IEA
(MGI:6201889|PMID:25049354)
GO_REF:0000107
RGD
Ensembl
PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase IMP RGD PMID:21712532 RGD:9590189 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (MGI:5543357|PMID:22555455) RGD PMID:22555455 MGI:5543357 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Plcg2 phospholipase C, gamma 2 acts_upstream_of
involved_in
ISO
IEA
(MGI:5300086|PMID:22041900)
GO_REF:0000107
RGD
Ensembl
PMID:22041900 GO_REF:0000107 MGI:5300086 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:24404184) RGD PMID:24404184 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G Slc5a3 solute carrier family 5 member 3 acts_upstream_of_or_within ISO (MGI:6414721|PMID:28128227) RGD PMID:28128227 MGI:6414721 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Tlr4 toll-like receptor 4 involved_in ISO
IEA
(MGI:4438693|PMID:20037584)
GO_REF:0000107
RGD
Ensembl
PMID:20037584 GO_REF:0000107 MGI:4438693 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:4438693 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
positive regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA RGD PMID:21376054 RGD:5129173 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:21076237 RGD:5129195 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:O88536 (PMID:11316806) RGD PMID:11316806 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cd177 CD177 molecule involved_in ISO UniProtKB:P05107|UniProtKB:P11215 (PMID:21193407) RGD PMID:21193407 NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621
JBrowse link
G Clec7a C-type lectin domain containing 7A involved_in ISO (PMID:19358895) RGD PMID:19358895 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
JBrowse link
G Crp C-reactive protein involved_in ISO (PMID:24141169) RGD PMID:24141169 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5586806|PMID:10725737)
Ensembl
RGD
PMID:10725737 GO_REF:0000107 MGI:5586806 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cyba cytochrome b-245 alpha chain IMP RGD PMID:15036821 RGD:8693734 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:22966991 RGD:7204494 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO
ISS
(PMID:11714832)
GO_REF:0000024
RGD
UniProt
PMID:11714832 GO_REF:0000024 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Fpr2 formyl peptide receptor 2 involved_in ISO UniProtKB:P05067:PRO_0000000092 (MGI:5905278|PMID:11316806) RGD PMID:11316806 MGI:5905278 NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019
JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:27912212 RGD:13507308 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 IMP RGD PMID:27912212 RGD:13507308 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5009187|PMID:11408560)
BHF-UCL
RGD
PMID:11408560 GO_REF:0000024 MGI:5009187 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hvcn1 hydrogen voltage-gated channel 1 IMP RGD PMID:24935944 RGD:14985214 NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141
JBrowse link
G Il18 interleukin 18 IMP RGD PMID:19497959 RGD:4889403 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Itgam integrin subunit alpha M involved_in ISO UniProtKB:P05107|UniProtKB:Q8N6Q3 (PMID:21193407)
(MGI:3812233|PMID:18685038), (MGI:3814938|PMID:18981141)
RGD PMID:18685038 PMID:18981141 PMID:21193407 MGI:3812233 MGI:3814938 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO UniProtKB:P11215|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Mapt microtubule-associated protein tau involved_in IEA
ISO
GO_REF:0000107
(PMID:22920254)
Ensembl
RGD
PMID:22920254 GO_REF:0000107 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 involved_in ISO (PMID:24141169) RGD PMID:24141169 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Prkcd protein kinase C, delta involved_in ISO
IEA
ISS
(PMID:19801500)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19801500 GO_REF:0000024 GO_REF:0000107 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Sod1 superoxide dismutase 1 involved_in ISO (PMID:18219391) RGD PMID:18219391 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO
IEA
(PMID:19358895)
GO_REF:0000107
RGD
Ensembl
PMID:19358895 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:22073128)
GO_REF:0000024
RGD
UniProt
PMID:22073128 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO (MGI:3812233|PMID:18685038) RGD PMID:18685038 MGI:3812233 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cellular metabolic process 10721
        positive regulation of cellular metabolic process 3332
          positive regulation of reactive oxygen species metabolic process 81
            positive regulation of hydrogen peroxide metabolic process + 8
            positive regulation of reactive oxygen species biosynthetic process + 23
            positive regulation of removal of superoxide radicals 0
            positive regulation of superoxide anion generation 25
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        positive regulation of biological process 6575
          positive regulation of cellular process 6053
            positive regulation of cellular metabolic process 3332
              positive regulation of reactive oxygen species metabolic process 81
                positive regulation of hydrogen peroxide metabolic process + 8
                positive regulation of reactive oxygen species biosynthetic process + 23
                positive regulation of removal of superoxide radicals 0
                positive regulation of superoxide anion generation 25
paths to the root