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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of reactive oxygen species metabolic process
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Accession:GO:2000378 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
Synonyms:exact_synonym: negative regulation of ROS metabolic process;   negative regulation of reactive oxygen species metabolism

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negative regulation of reactive oxygen species metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor involved_in ISO (PMID:15207272) RGD PMID:15207272 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851 		JBrowse link
G Atg5 autophagy related 5 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q61221 (MGI:3796473|PMID:18281291)		 Ensembl
RGD		 PMID:18281291 GO_REF:0000107 MGI:3796473 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q61221 (MGI:3796473|PMID:18281291)		 Ensembl
RGD		 PMID:18281291 GO_REF:0000107 MGI:3796473 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO MGI:2154396 (MGI:71493|PMID:7889565) RGD PMID:7889565 MGI:71493 NCBI chr20:14,421,250...14,546,406
Ensembl chr20:14,421,141...14,545,772 		JBrowse link
G Becn1 beclin 1 involved_in ISO UniProtKB:Q61221 (MGI:3796473|PMID:18281291) RGD PMID:18281291 MGI:3796473 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO UniProtKB:Q61221 (MGI:3796473|PMID:18281291) RGD PMID:18281291 MGI:3796473 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in ISO
IEA		 (PMID:23415688)
GO_REF:0000107		 RGD
Ensembl		 PMID:23415688 GO_REF:0000107 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Cryab crystallin, alpha B IDA RGD PMID:15358243 RGD:1598485 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:23608653 RGD:7364951 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase IMP RGD PMID:24190878 RGD:10449133 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in IEA
ISO		 GO_REF:0000107
(MGI:3796473|PMID:18281291)		 Ensembl
RGD		 PMID:18281291 GO_REF:0000107 MGI:3796473 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hk2 hexokinase 2 involved_in ISO (MGI:5619449|PMID:22517678) RGD PMID:22517678 MGI:5619449 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
Ensembl chr 9:47,186,558...47,244,416 		JBrowse link
G Mt3 metallothionein 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18554677)		 UniProt
RGD		 PMID:18554677 GO_REF:0000024 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor involved_in IEA
ISO		 GO_REF:0000107
(MGI:5050076|PMID:17357786)		 Ensembl
RGD		 PMID:17357786 GO_REF:0000107 MGI:5050076 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379 		JBrowse link
G Pax2 paired box 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17357786)		 UniProt
RGD		 PMID:17357786 GO_REF:0000024 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:18560593) RGD PMID:18560593 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415 		JBrowse link
G Plin5 perilipin 5 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5440401|PMID:22532565)		 UniProt
RGD		 PMID:22532565 GO_REF:0000024 MGI:5440401 NCBI chr 9:10,956,013...10,961,782
Ensembl chr 9:10,956,056...10,961,782 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
ISS		 UniProtKB:Q9H4P4 (PMID:18541373)
GO_REF:0000024		 RGD
ParkinsonsUK-UCL		 PMID:18541373 GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Sirt2 sirtuin 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5572869|PMID:17521387)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:17521387 GO_REF:0000024 GO_REF:0000107 MGI:5572869 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952 		JBrowse link
G Sirt3 sirtuin 3 IMP RGD PMID:23397292 RGD:9586042 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Sirt5 sirtuin 5 involved_in ISO (PMID:24140062) RGD PMID:24140062 NCBI chr17:23,986,710...24,013,854
Ensembl chr17:23,986,758...24,013,881 		JBrowse link
G Tfap2a transcription factor AP-2 alpha involved_in ISS
ISO		 GO_REF:0000024
(PMID:20066163)		 UniProt
RGD		 PMID:20066163 GO_REF:0000024 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO MGI:5319187 (MGI:5319065|PMID:22044588) RGD PMID:22044588 MGI:5319065 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:1857263 (MGI:5319065|PMID:22044588) RGD PMID:22044588 MGI:5319065 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 involved_in ISO (MGI:5689082|PMID:25470454) RGD PMID:25470454 MGI:5689082 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826 		JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:59,749,250...59,772,475
Ensembl chr10:59,749,256...59,764,868 		JBrowse link
G Cycs cytochrome c, somatic IMP RGD PMID:21410437 RGD:7349317 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:3,321,488...3,359,219
Ensembl chr10:3,321,476...3,357,470 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:23590160 RGD:8694322 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
negative regulation of hydrogen peroxide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hp haptoglobin involved_in ISO (PMID:19740759) RGD PMID:19740759 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804 		JBrowse link
G Mt3 metallothionein 3 IDA RGD PMID:12058024 RGD:625483 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139 		JBrowse link
negative regulation of hydrogen peroxide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp3 matrix metallopeptidase 3 involved_in ISO
IEA		 (PMID:20969476)
GO_REF:0000107		 RGD
Ensembl		 PMID:20969476 GO_REF:0000107 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11991626 RGD:10003093 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3836690|PMID:18723473), (MGI:5464985|PMID:22521832), (MGI:5790173|PMID:25583114)		 UniProt
RGD		 PMID:18723473 PMID:22521832 PMID:25583114 GO_REF:0000024 MGI:3836690 MGI:5464985 MGI:5790173 NCBI chr  X:157,073,860...157,095,652
Ensembl chr  X:157,072,736...157,095,274 		JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3836690|PMID:18723473)		 UniProt
RGD		 PMID:18723473 GO_REF:0000024 MGI:3836690 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 IMP RGD PMID:22209705 RGD:13800744 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator IMP RGD PMID:18292530 RGD:11341712 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Coa8 cytochrome c oxidase assembly factor 8 involved_in ISO
ISS		 (PMID:25175347)
GO_REF:0000024		 RGD
UniProt		 PMID:25175347 GO_REF:0000024 NCBI chr 6:136,185,772...136,210,936
NCBI chr 6:136,279,476...136,304,317
Ensembl chr 6:136,185,487...136,210,940
Ensembl chr 6:136,185,487...136,210,940 		JBrowse link
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:59,749,250...59,772,475
Ensembl chr10:59,749,256...59,764,868 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 IMP RGD PMID:23041468 RGD:10401126 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818 		JBrowse link
G Hbp1 HMG-box transcription factor 1 involved_in ISO (MGI:5754467|PMID:24675724) RGD PMID:24675724 MGI:5754467 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IMP RGD PMID:22547655 RGD:10402548 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Ins2 insulin 2 involved_in ISO ComplexPortal:CPX-1134 (PMID:19188609) RGD PMID:19188609 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:28483668 RGD:12910717 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145 		JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IMP RGD PMID:26888427 RGD:11040458 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO		 GO_REF:0000024
(MGI:5908331|PMID:22611253)		 UniProt
RGD		 PMID:22611253 GO_REF:0000024 MGI:5908331 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha acts_upstream_of ISO (PMID:31574452) RGD PMID:31574452 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:24096089 RGD:10413842 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rhoa ras homolog family member A involved_in ISO (MGI:5640904|PMID:25398325) RGD PMID:25398325 MGI:5640904 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:23422569 RGD:9585767 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc30a10 solute carrier family 30, member 10 involved_in ISO (PMID:22427991) RGD PMID:22427991 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363 		JBrowse link
negative regulation of superoxide anion generation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor involved_in ISO (PMID:15207272) RGD PMID:15207272 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2180086 (MGI:1930064|PMID:11168643)		 Ensembl
RGD		 PMID:11168643 GO_REF:0000107 MGI:1930064 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IMP RGD PMID:24601882 RGD:39128160 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Crp C-reactive protein IDA RGD PMID:9767445 RGD:9586000 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Pon3 paraoxonase 3 involved_in ISO (MGI:5543365|PMID:22441669) RGD PMID:22441669 MGI:5543365 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    cellular process 18481
      cellular metabolic process 10866
        negative regulation of cellular metabolic process 2711
          negative regulation of reactive oxygen species metabolic process 55
            negative regulation of hydrogen peroxide metabolic process + 9
            negative regulation of reactive oxygen species biosynthetic process + 22
            negative regulation of removal of superoxide radicals + 0
            negative regulation of superoxide anion generation 5
Path 2
Term Annotations click to browse term
  biological_process 19634
    biological regulation 13612
      regulation of biological process 12859
        negative regulation of biological process 5637
          negative regulation of cellular process 5131
            negative regulation of cellular metabolic process 2711
              negative regulation of reactive oxygen species metabolic process 55
                negative regulation of hydrogen peroxide metabolic process + 9
                negative regulation of reactive oxygen species biosynthetic process + 22
                negative regulation of removal of superoxide radicals + 0
                negative regulation of superoxide anion generation 5
paths to the root