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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of signaling receptor activity
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Accession:GO:2000272 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.
Synonyms:exact_synonym: negative regulation of signalling receptor activity
 broad_synonym: negative regulation of receptor activity



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negative regulation of signaling receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 acts_upstream_of
involved_in
ISO
IEA
(PMID:18258853)
GO_REF:0000107
RGD
Ensembl
PMID:18258853 GO_REF:0000107 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
JBrowse link
G Clec12b C-type lectin domain family 12, member B involved_in ISO
IBA
(PMID:17562706)
PMID:21873635
RGD PMID:17562706 PMID:21873635 RGD:13792537 NCBI chr 4:162,827,462...162,843,821
Ensembl chr 4:162,827,462...162,838,946
JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 involved_in ISO
IBA
(PMID:17895407)
PMID:21873635
RGD PMID:17895407 PMID:21873635 RGD:13792537 NCBI chr14:91,463,046...91,492,736
Ensembl chr14:91,462,647...91,492,735
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
JBrowse link
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr16:69,402,989...69,406,580
Ensembl chr16:69,402,989...69,406,580
JBrowse link
G Dkkl1 dickkopf like acrosomal protein 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:95,694,010...95,699,259
Ensembl chr 1:95,694,010...95,699,259
JBrowse link
G Dut deoxyuridine triphosphatase involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
JBrowse link
G Hfe homeostatic iron regulator involved_in ISO (PMID:9465039) RGD PMID:9465039 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:9151699) RGD PMID:9151699 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G LOC100361556 rCG60069-like involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:106,863,167...106,867,047
Ensembl chr 7:106,865,291...106,867,047
JBrowse link
G LOC120093891 lymphocyte antigen 6D-like involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:106,653,721...106,661,132
Ensembl chr 7:106,653,516...106,660,895
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414
JBrowse link
G Ly6c Ly6-C antigen involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:106,959,508...106,963,360
Ensembl chr 7:106,959,511...106,963,329
JBrowse link
G Ly6e lymphocyte antigen 6 family member E involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
JBrowse link
G Ly6g6d lymphocyte antigen 6 family member G6D involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:3,749,598...3,752,181
Ensembl chr20:3,737,459...3,752,248
JBrowse link
G Ly6h lymphocyte antigen 6 family member H involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:107,258,779...107,261,270
Ensembl chr 7:107,258,779...107,261,454
JBrowse link
G Ly6i lymphocyte antigen 6 complex, locus I involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:107,062,320...107,067,743
Ensembl chr 7:107,062,325...107,067,310
JBrowse link
G Lynx1 Ly6/neurotoxin 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023
JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493
JBrowse link
G Lypd6 LY6/PLAUR domain containing 6 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:34,487,222...34,632,887
Ensembl chr 3:34,496,485...34,630,308
JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 6:137,342,449...137,418,083
Ensembl chr 6:137,342,943...137,415,159
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha acts_upstream_of ISO (PMID:12700342) RGD PMID:12700342 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of ISO (PMID:12700342) RGD PMID:12700342 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IMP extrasynaptic NMDAR RGD PMID:22593067 RGD:6484258 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Pten phosphatase and tensin homolog IMP GABA A receptors RGD PMID:24044036 RGD:12802358 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (MGI:4942251|PMID:12771128) RGD PMID:12771128 MGI:4942251 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
JBrowse link
G RGD1565410 similar to Ly6-C antigen gene involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:107,122,197...107,163,755
Ensembl chr 7:107,011,588...107,163,788
JBrowse link
G Slurp2 secreted LY6/PLAUR domain containing 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:106,627,775...106,631,655
Ensembl chr 7:106,627,775...106,631,655
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of ISO (PMID:10443688) RGD PMID:10443688 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:14,896,442...14,898,770
Ensembl chr10:14,896,378...14,899,863
JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:79,185,563...79,192,719
Ensembl chr10:79,186,647...79,191,657
JBrowse link
cross-receptor inhibition within G protein-coupled receptor heterodimer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor involved_in ISO UniProtKB:O60896 (PMID:14722252) RGD PMID:14722252 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Ramp3 receptor activity modifying protein 3 involved_in ISO UniProtKB:P30988 (PMID:14722252) RGD PMID:14722252 NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902
JBrowse link
negative regulation of advanced glycation end-product receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor acts_upstream_of_or_within ISO (MGI:3692350|PMID:16503878) RGD PMID:16503878 MGI:3692350 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
negative regulation of brain-derived neurotrophic factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fam72a family with sequence similarity 72, member A acts_upstream_of_or_within IDA PMID:19755123 MGI PMID:19755123 RGD:8553945 NCBI chr13:42,968,409...42,978,976
Ensembl chr13:42,967,578...42,984,208
JBrowse link
negative regulation of corticotropin-releasing hormone receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhbp corticotropin releasing hormone binding protein involved_in IBA
IEA
ISS
ISO
PMID:21873635
GO_REF:0000107
GO_REF:0000024
(PMID:18234674)
Ensembl
UniProt
RGD
PMID:18234674 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
JBrowse link
G Cblb Cbl proto-oncogene B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO
IBA
(PMID:10362357)
PMID:21873635
RGD PMID:10362357 PMID:21873635 RGD:13792537 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
JBrowse link
G Chmp6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:105,191,972...105,197,642
Ensembl chr10:105,191,950...105,197,640
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in ISS
ISO
IDA
GO_REF:0000024
(MGI:3629275|PMID:16648858)
PMID:17599051
(PMID:18046415)
UniProt
RGD
PMID:16648858 PMID:18046415 PMID:17599051 GO_REF:0000024 MGI:3629275, RGD:8553726 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A involved_in ISO (MGI:5635952|PMID:25744720) RGD PMID:25744720 MGI:5635952 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260
JBrowse link
G Psen1 presenilin 1 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Socs4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554
JBrowse link
G Vps25 vacuolar protein sorting 25 homolog involved_in ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:86,196,062...86,201,606
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 involved_in ISO
IBA
(PMID:19460345)
PMID:21873635
RGD PMID:19460345 PMID:21873635 RGD:13792537 NCBI chr14:76,468,424...76,554,039
Ensembl chr14:76,468,424...76,554,039
JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing involved_in ISO
ISS
(PMID:19644445)
GO_REF:0000024
RGD
UniProt
PMID:19644445 GO_REF:0000024 NCBI chr 3:168,473,836...168,490,380
Ensembl chr 3:168,473,981...168,490,380
JBrowse link
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephb2 Eph receptor B2 involved_in ISO (MGI:4867584|PMID:21113149) RGD PMID:21113149 MGI:4867584 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Park7 Parkinsonism associated deglycase IMP RGD PMID:20698836 RGD:13463453 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Slc6a9 solute carrier family 6 member 9 acts_upstream_of ISO (MGI:3044468|PMID:15159536) RGD PMID:15159536 MGI:3044468 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    biological regulation 13616
      regulation of molecular function 3073
        regulation of signaling receptor activity 170
          negative regulation of signaling receptor activity 57
            cross-receptor inhibition within G protein-coupled receptor heterodimer 2
            negative regulation of AMPA receptor activity 0
            negative regulation of GABA-A receptor activity 0
            negative regulation of NMDA glutamate receptor activity 3
            negative regulation of acetylcholine-gated cation channel activity 0
            negative regulation of advanced glycation end-product receptor activity 1
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of brain-derived neurotrophic factor-activated receptor activity 1
            negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
            negative regulation of corticotropin-releasing hormone receptor activity 1
            negative regulation of epidermal growth factor-activated receptor activity 14
            negative regulation of nerve growth factor receptor activity 0
            negative regulation of osmolarity-sensing cation channel activity 0
            negative regulation of proteinase activated receptor activity 0
Path 2
Term Annotations click to browse term
  biological_process 19512
    biological regulation 13616
      regulation of biological process 12887
        regulation of cellular process 12364
          signal transduction 6952
            regulation of signal transduction 3009
              regulation of signaling receptor activity 170
                negative regulation of signaling receptor activity 57
                  cross-receptor inhibition within G protein-coupled receptor heterodimer 2
                  negative regulation of AMPA receptor activity 0
                  negative regulation of GABA-A receptor activity 0
                  negative regulation of NMDA glutamate receptor activity 3
                  negative regulation of acetylcholine-gated cation channel activity 0
                  negative regulation of advanced glycation end-product receptor activity 1
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of brain-derived neurotrophic factor-activated receptor activity 1
                  negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
                  negative regulation of corticotropin-releasing hormone receptor activity 1
                  negative regulation of epidermal growth factor-activated receptor activity 14
                  negative regulation of nerve growth factor receptor activity 0
                  negative regulation of osmolarity-sensing cation channel activity 0
                  negative regulation of proteinase activated receptor activity 0
paths to the root