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ONTOLOGY REPORT - ANNOTATIONS


Term:mRNA N6-methyladenosine dioxygenase activity
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Accession:GO:1990931 term browser browse the term
Definition:Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
Synonyms:exact_synonym: mRNA N(6)-methyladenine demethylase;   mRNA N(6)-methyladenosine dioxygenase activity
 related_synonym: RNA N6-methyladenosine dioxygenase activity
 xref: EC:1.14.11.53;   RHEA:49520


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mRNA N6-methyladenosine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKBH5 alkB homolog 5, RNA demethylase enables IEA Ensembl GO_REF:0000107 NCBI chr16:17,221,643...17,249,038
Ensembl chr16:17,222,378...17,249,117
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G FTO FTO alpha-ketoglutarate dependent dioxygenase enables IEA UniProt
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Ensembl
GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:39,487,304...39,900,238
Ensembl chr 5:39,487,418...39,725,747
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Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19846
    catalytic activity 5465
      demethylase activity 37
        oxidative RNA demethylase activity 5
          mRNA N6-methyladenosine dioxygenase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 19846
    catalytic activity 5465
      oxidoreductase activity 717
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 183
          2-oxoglutarate-dependent dioxygenase activity 59
            oxidative RNA demethylase activity 5
              mRNA N6-methyladenosine dioxygenase activity 2
paths to the root