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ONTOLOGY REPORT - ANNOTATIONS


Term:mRNA N6-methyladenosine dioxygenase activity
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Accession:GO:1990931 term browser browse the term
Definition:Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
Synonyms:exact_synonym: mRNA N(6)-methyladenine demethylase;   mRNA N(6)-methyladenosine dioxygenase activity
 related_synonym: RNA N6-methyladenosine dioxygenase activity
 xref: EC:1.14.11.53;   RHEA:49520


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mRNA N6-methyladenosine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh5 alkB homolog 5, RNA demethylase enables ISO (PMID:23177736), (PMID:24616105), (PMID:34048572), (PMID:35333330), (PMID:36944332), (PMID:37257451), (PMID:37369679), (PMID:37474102)
(PMID:29279410), (PMID:35939687), (PMID:36859428)
UniProt PMID:23177736 PMID:24616105 PMID:29279410 PMID:34048572 PMID:35333330 More... NCBI chrNW_004955478:11,104,445...11,128,980
Ensembl chrNW_004955478:11,105,920...11,128,222
JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase enables ISO (PMID:25452335), (PMID:26457839), (PMID:30197295)
(PMID:26458103)
UniProt PMID:25452335 PMID:26457839 PMID:26458103 PMID:30197295 NCBI chrNW_004955433:11,424,069...11,834,955
Ensembl chrNW_004955433:11,424,176...11,813,771
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14382
    catalytic activity 3778
      demethylase activity 32
        oxidative RNA demethylase activity 5
          mRNA N6-methyladenosine dioxygenase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 14382
    catalytic activity 3778
      oxidoreductase activity 479
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 114
          2-oxoglutarate-dependent dioxygenase activity 53
            oxidative RNA demethylase activity 5
              mRNA N6-methyladenosine dioxygenase activity 2
paths to the root