ONTOLOGY REPORT - ANNOTATIONS
Term: Wnt signalosome
Accession: GO:1990909
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Definition: A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
Comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
Synonyms: exact_synonym: LRP5/6 signalosome; Wnt signalosome complex; Wnt-LRP5/6 signalosome
narrow_synonym: LRP6 signalosome
G
Adgra2
adhesion G protein-coupled receptor A2
part_of
ISO IEA IBA
(PMID:30026314) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:30026314
GO_REF:0000033 GO_REF:0000107
NCBI chr16:71,635,814...71,674,275
Ensembl chr16:71,636,164...71,674,154
G
Axin1
axin 1
part_of
IEA ISO
GO_REF:0000107 (PMID:22899650)
Ensembl RGD
PMID:22899650
GO_REF:0000107
NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092
G
Ctnnb1
catenin beta 1
part_of
IEA ISO
GO_REF:0000107 (PMID:22899650)
Ensembl RGD
PMID:22899650
GO_REF:0000107
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
G
Dvl1
dishevelled segment polarity protein 1
part_of
ISO IEA
(PMID:22899650) GO_REF:0000107
RGD Ensembl
PMID:22899650
GO_REF:0000107
NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:171,739,133...171,750,966
G
Dvl3
dishevelled segment polarity protein 3
part_of
ISO
(PMID:22899650)
RGD
PMID:22899650
NCBI chr11:93,869,834...93,887,013
Ensembl chr11:93,869,834...93,886,903
G
Gsk3b
glycogen synthase kinase 3 beta
part_of
ISO
(PMID:22899650)
RGD
PMID:22899650
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
G
Lrp6
LDL receptor related protein 6
part_of
ISO IEA
(PMID:22899650) GO_REF:0000107
RGD Ensembl
PMID:22899650
GO_REF:0000107
NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716
G
Lrrk2
leucine-rich repeat kinase 2
part_of
ISO IEA
(PMID:22899650) GO_REF:0000107 GO_REF:0000117
RGD Ensembl UniProt
PMID:22899650
GO_REF:0000107 GO_REF:0000117
NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239
G
Mamdc4
MAM domain containing 4
part_of
ISO
(PMID:38787854)
RGD
PMID:38787854
NCBI chr 3:8,382,387...8,391,003
Ensembl chr 3:28,780,523...28,789,139
G
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
part_of
ISO IEA
(PMID:30026314) GO_REF:0000107
RGD Ensembl
PMID:30026314
GO_REF:0000107
NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270
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