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Term:Wnt signalosome
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Accession:GO:1990909 term browser browse the term
Definition:A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
Comment:Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
Synonyms:exact_synonym: LRP5/6 signalosome;   Wnt signalosome complex;   Wnt-LRP5/6 signalosome
 narrow_synonym: LRP6 signalosome

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Wnt signalosome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgra2 adhesion G protein-coupled receptor A2 ISO
RGD PMID:30026314, PMID:21873635 RGD:13792537 NCBI chr16:69,094,587...69,133,015
Ensembl chr16:69,095,936...69,132,584
JBrowse link
G Axin1 axin 1 ISO (MGI:MGI:5440351|PMID:22899650) RGD PMID:22899650 MGI:MGI:5440351
G Ctnnb1 catenin beta 1 ISO
PMID:22899650 GO_REF:0000107, MGI:MGI:5440351 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 ISO (MGI:MGI:5440351|PMID:22899650) RGD PMID:22899650 MGI:MGI:5440351 NCBI chr 5:173,295,948...173,308,014
Ensembl chr 5:173,296,270...173,307,945
JBrowse link
G Dvl3 dishevelled segment polarity protein 3 ISO (MGI:MGI:5440351|PMID:22899650) RGD PMID:22899650 MGI:MGI:5440351 NCBI chr11:84,051,177...84,068,479
Ensembl chr11:84,051,078...84,068,302
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO (MGI:MGI:5440351|PMID:22899650) RGD PMID:22899650 MGI:MGI:5440351 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Lrp6 LDL receptor related protein 6 ISO (PMID:22899650) RGD PMID:22899650 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO (PMID:22899650)
RGD PMID:22899650 MGI:MGI:5440351 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs ISO (MGI:MGI:6255947|PMID:30026314) RGD PMID:30026314 MGI:MGI:6255947 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link

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  cellular_component 20609
    protein-containing complex 6093
      Wnt signalosome 9
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