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ONTOLOGY REPORT - ANNOTATIONS

Term:Wnt signalosome
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Accession:GO:1990909 term browser browse the term
Definition:A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
Comment:Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
Synonyms:exact_synonym: LRP5/6 signalosome;   Wnt signalosome complex;   Wnt-LRP5/6 signalosome
 narrow_synonym: LRP6 signalosome


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Wnt signalosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgra2 adhesion G protein-coupled receptor A2 part_of ISO
IEA
IBA 		(PMID:30026314)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:30026314 GO_REF:0000033 GO_REF:0000107 NCBI chr16:71,635,814...71,674,275
Ensembl chr16:71,636,164...71,674,154 		JBrowse link
G Axin1 axin 1 part_of IEA
ISO 		GO_REF:0000107
(PMID:22899650) 		Ensembl
RGD		 PMID:22899650 GO_REF:0000107 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092 		JBrowse link
G Ctnnb1 catenin beta 1 part_of IEA
ISO 		GO_REF:0000107
(PMID:22899650) 		Ensembl
RGD		 PMID:22899650 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 part_of ISO
IEA 		(PMID:22899650)
GO_REF:0000107 		RGD
Ensembl		 PMID:22899650 GO_REF:0000107 NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:171,739,133...171,750,966 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 part_of ISO (PMID:22899650) RGD PMID:22899650 NCBI chr11:93,869,834...93,887,013
Ensembl chr11:93,869,834...93,886,903 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta part_of ISO (PMID:22899650) RGD PMID:22899650 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Lrp6 LDL receptor related protein 6 part_of ISO
IEA 		(PMID:22899650)
GO_REF:0000107 		RGD
Ensembl		 PMID:22899650 GO_REF:0000107 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 part_of ISO
IEA 		(PMID:22899650)
GO_REF:0000107
GO_REF:0000117 		RGD
Ensembl
UniProt		 PMID:22899650 GO_REF:0000107 GO_REF:0000117 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239 		JBrowse link
G Mamdc4 MAM domain containing 4 part_of ISO (PMID:38787854) RGD PMID:38787854 NCBI chr 3:8,382,387...8,391,003
Ensembl chr 3:28,780,523...28,789,139 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs part_of ISO
IEA 		(PMID:30026314)
GO_REF:0000107 		RGD
Ensembl		 PMID:30026314 GO_REF:0000107 NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21544
    protein-containing complex 6918
      Wnt signalosome 10
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