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Term:Wnt signalosome
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Accession:GO:1990909 term browser browse the term
Definition:A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
Comment:Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
Synonyms:exact_synonym: LRP5/6 signalosome;   Wnt signalosome complex;   Wnt-LRP5/6 signalosome
 narrow_synonym: LRP6 signalosome

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Wnt signalosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgra2 adhesion G protein-coupled receptor A2 part_of ISO
RGD PMID:30026314 PMID:21873635 RGD:13792537 NCBI chr16:64,932,964...64,971,433
Ensembl chr16:64,933,315...64,971,483
JBrowse link
G Axin1 axin 1 part_of ISO (MGI:5440351|PMID:22899650) RGD PMID:22899650 MGI:5440351 NCBI chr10:15,163,684...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Ctnnb1 catenin beta 1 part_of IEA
PMID:22899650 GO_REF:0000107 MGI:5440351 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 part_of ISO (MGI:5440351|PMID:22899650) RGD PMID:22899650 MGI:5440351 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Dvl3 dishevelled segment polarity protein 3 part_of ISO (MGI:5440351|PMID:22899650) RGD PMID:22899650 MGI:5440351 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta part_of ISO (MGI:5440351|PMID:22899650) RGD PMID:22899650 MGI:5440351 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Lrp6 LDL receptor related protein 6 part_of ISO (PMID:22899650) RGD PMID:22899650 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 part_of ISO (PMID:22899650)
RGD PMID:22899650 MGI:5440351 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs part_of ISO (MGI:6255947|PMID:30026314) RGD PMID:30026314 MGI:6255947 NCBI chr 5:58,102,915...58,169,513
Ensembl chr 5:58,102,981...58,169,502
JBrowse link

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  cellular_component 19969
    protein-containing complex 6165
      Wnt signalosome 9
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