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ONTOLOGY REPORT - ANNOTATIONS

Term:Wnt-Frizzled-LRP5/6 complex
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Accession:GO:1990851 term browser browse the term
Definition:A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6.
Comment:Given the number of Wnt proteins, Frizzled proteins and LRP proteins, many different trimeric complexes are likely to form.
Synonyms:exact_synonym: Wnt-FZD-LRP5/6 trimeric complex;   Wnt.Fz.LRP ternary complex
 narrow_synonym: Fz/Wnt/LRP6 complex;   WNT-FZD-LRP5 complex;   WNT-FZD-LRP6 complex
 broad_synonym: Wnt receptor complex
 related_synonym: Frizzled-LRP5/6 complex;   Wnt-induced Frizzled-LRP5/6 complex

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Wnt-Frizzled-LRP5/6 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd8 frizzled class receptor 8 part_of ISO UniProtKB:O75581 (MGI:4839462|PMID:11029007), (MGI:5532920|PMID:11448771), (MGI:5706913|PMID:20093360) RGD PMID:11029007 PMID:11448771 PMID:20093360 MGI:4839462 MGI:5532920 MGI:5706913 NCBI chr17:62,259,910...62,267,239
Ensembl chr17:62,262,129...62,265,113
Ensembl chr17:62,262,129...62,265,113 		JBrowse link
G Lrp6 LDL receptor related protein 6 part_of ISO UniProtKB:Q61091 (PMID:11029007), (PMID:11448771), (PMID:20093360) RGD PMID:11029007 PMID:11448771 PMID:20093360 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751 		JBrowse link
G Wnt3a Wnt family member 3A part_of ISO (PMID:20093360) RGD PMID:20093360 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20137
    protein-containing complex 5955
      membrane protein complex 1240
        plasma membrane protein complex 562
          Wnt-Frizzled-LRP5/6 complex 3
Path 2
Term Annotations click to browse term
  cellular_component 20137
    cellular anatomical entity 19833
      membrane 10004
        plasma membrane 6224
          plasma membrane protein complex 562
            Wnt-Frizzled-LRP5/6 complex 3
paths to the root