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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:ligand-gated ion channel signaling pathway
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Accession:GO:1990806 term browser browse the term
Definition:The series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: ligand-gated ion channel signalling pathway

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ligand-gated ion channel signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa7 annexin A7 acts_upstream_of_or_within_positive_effect ISO (PMID:10570150) MGI PMID:10570150 NCBI chrNW_004936521:5,639,193...5,671,369
Ensembl chrNW_004936521:5,651,719...5,671,050 		JBrowse link
G Chrm3 cholinergic receptor muscarinic 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:13,953,141...14,373,174
Ensembl chrNW_004936484:13,954,887...13,956,659 		JBrowse link
G F2 coagulation factor II, thrombin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650 		JBrowse link
G F2rl2 coagulation factor II thrombin receptor like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936549:336,871...342,992
Ensembl chrNW_004936549:337,024...342,948 		JBrowse link
G Ffar1 free fatty acid receptor 1 involved_in ISO (PMID:31664108) MGI PMID:31664108 NCBI chrNW_004936570:955,102...957,437 JBrowse link
G Gna11 G protein subunit alpha 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:1,770,777...1,789,143
Ensembl chrNW_004936588:1,770,771...1,789,170 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936577:3,896,455...4,198,396
Ensembl chrNW_004936577:3,896,390...4,198,411 		JBrowse link
G LOC101971238 free fatty acid receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:895,364...896,356
Ensembl chrNW_004936570:895,364...896,356 		JBrowse link
G LOC101971998 guanine nucleotide-binding protein G(q) subunit alpha involved_in ISO (PMID:20440069)
(PMID:26075576)		 MGI PMID:20440069 PMID:26075576 NCBI chrNW_004936503:13,098,517...13,276,106
Ensembl chrNW_004936503:13,099,558...13,276,152 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 involved_in ISO (PMID:31664108) MGI PMID:31664108 NCBI chrNW_004936558:2,730,098...2,743,062 JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:10,548,966...11,254,139
Ensembl chrNW_004936485:10,548,966...11,253,761 		JBrowse link
G Stim1 stromal interaction molecule 1 involved_in ISO (PMID:18452988)
(PMID:30131394), (PMID:31664108)
(PMID:31664108)		 MGI PMID:18452988 PMID:30131394 PMID:31664108 NCBI chrNW_004936498:849,775...1,063,552
Ensembl chrNW_004936498:849,739...1,063,552 		JBrowse link
AMPA selective glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C acts_upstream_of_negative_effect ISO (MGI:3804504|PMID:18599438) Alzheimers_University_of_Toronto PMID:18599438 MGI:3804504 NCBI chrNW_004936469:7,060,480...7,225,497
Ensembl chrNW_004936469:7,060,480...7,204,661 		JBrowse link
G Plp1 proteolipid protein 1 ISO RGD PMID:16510724 RGD:30296668 NCBI chrNW_004936499:10,534,953...10,553,411
Ensembl chrNW_004936499:10,534,950...10,551,012 		JBrowse link
ionotropic glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16025111) Ensembl
MGI		 PMID:16025111 GO_REF:0000107 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO (PMID:17234593) MGI PMID:17234593 NCBI chrNW_004936706:476,473...494,659
Ensembl chrNW_004936706:477,107...495,525 		JBrowse link
G Camk2a calcium/calmodulin dependent protein kinase II alpha involved_in ISO PMID:12223541 UniProt PMID:12223541 RGD:8554161 NCBI chrNW_004936504:4,636,863...4,700,887
Ensembl chrNW_004936504:4,638,176...4,700,984 		JBrowse link
G Cdk5r1 cyclin dependent kinase 5 regulatory subunit 1 involved_in ISO PMID:12223541 UniProt PMID:12223541 RGD:8554161 NCBI chrNW_004936538:2,411,194...2,415,106
Ensembl chrNW_004936538:2,413,967...2,414,890 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16483786) Ensembl
MGI		 PMID:16483786 GO_REF:0000107 NCBI chrNW_004936501:11,955,334...11,967,338
Ensembl chrNW_004936501:11,955,184...11,967,436 		JBrowse link
G Cpeb4 cytoplasmic polyadenylation element binding protein 4 involved_in ISO PMID:20937770 UniProt PMID:20937770 RGD:8553637 NCBI chrNW_004936609:1,793,027...1,858,586
Ensembl chrNW_004936609:1,793,027...1,858,597 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936515:8,937,391...9,236,438
Ensembl chrNW_004936515:8,940,009...9,083,151 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chrNW_004936576:3,800,369...3,940,324
Ensembl chrNW_004936576:3,800,075...3,941,003 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936479:7,050,018...7,323,047
Ensembl chrNW_004936479:7,050,016...7,323,196 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936551:2,426,840...2,760,042
Ensembl chrNW_004936551:2,425,080...2,760,189 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:3629813|PMID:15483117) RGD
GOC
GOC		 PMID:15483117 PMID:17395219 GO_REF:0000108 MGI:3629813 RGD:1642466 NCBI chrNW_004936500:12,157,215...12,536,555
Ensembl chrNW_004936500:12,157,765...12,536,224 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936651:2,756,559...3,401,806
Ensembl chrNW_004936651:2,762,380...3,401,808 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936474:19,151,896...19,363,497
Ensembl chrNW_004936474:19,156,172...19,363,542 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936542:5,600,517...5,764,042
Ensembl chrNW_004936542:5,599,785...5,763,616 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936706:410,806...469,000
Ensembl chrNW_004936706:410,938...464,714 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:16025111) RGD
TreeGrafter
MGI
Ensembl		 PMID:16025111 PMID:16477151 GO_REF:0000107 GO_REF:0000118 RGD:1642190 NCBI chrNW_004936669:814,330...838,881
Ensembl chrNW_004936669:814,330...839,208 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A involved_in ISO
IEA		 RGD
GOC		 PMID:16477151 GO_REF:0000108 RGD:1642190 NCBI chrNW_004936530:8,286,101...8,612,183
Ensembl chrNW_004936530:8,287,574...8,608,343 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B involved_in ISO
IEA		 RGD
GOC		 PMID:16477151 GO_REF:0000108 RGD:1642190 NCBI chrNW_004936587:3,406,055...3,806,956
Ensembl chrNW_004936587:3,405,698...3,804,664 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936594:197,337...208,468
Ensembl chrNW_004936594:197,737...208,376 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936664:2,512,777...2,546,865
Ensembl chrNW_004936664:2,515,928...2,546,429 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:16477151 GO_REF:0000118 RGD:1642190 NCBI chrNW_004936524:9,720,777...9,884,984
Ensembl chrNW_004936524:9,720,767...9,885,120 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:11823786 GO_REF:0000118 RGD:632842 NCBI chrNW_004936588:433,544...440,534
Ensembl chrNW_004936588:433,261...444,237 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISO PMID:15814199 Alzheimers_University_of_Toronto PMID:15814199 RGD:8655534 NCBI chrNW_004936675:216,970...325,670
Ensembl chrNW_004936675:275,288...324,810 		JBrowse link
NMDA selective glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2a calcium/calmodulin dependent protein kinase II alpha involved_in ISO PMID:20670832 SynGO PMID:20670832 RGD:12050125 NCBI chrNW_004936504:4,636,863...4,700,887
Ensembl chrNW_004936504:4,638,176...4,700,984 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B involved_in ISO PMID:15987933 SynGO PMID:15987933 RGD:12050132 NCBI chrNW_004936587:3,406,055...3,806,956
Ensembl chrNW_004936587:3,405,698...3,804,664 		JBrowse link
G Kalrn kalirin RhoGEF kinase involved_in ISO PMID:18031682 SynGO PMID:18031682 RGD:12050112 NCBI chrNW_004936725:749,382...1,020,702
Ensembl chrNW_004936725:572,868...1,139,142 		JBrowse link
G Mef2c myocyte enhancer factor 2C acts_upstream_of_negative_effect ISO (MGI:3804504|PMID:18599438) Alzheimers_University_of_Toronto PMID:18599438 MGI:3804504 NCBI chrNW_004936469:7,060,480...7,225,497
Ensembl chrNW_004936469:7,060,480...7,204,661 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 involved_in ISO PMID:15721239 SynGO PMID:15721239 RGD:12050147 NCBI chrNW_004936500:10,451,599...10,812,239
Ensembl chrNW_004936500:10,688,236...10,812,192 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    cellular process 15075
      signal transduction 5702
        ligand-gated ion channel signaling pathway 39
          ionotropic glutamate receptor signaling pathway + 27
          serotonin-gated cation-selective signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 15969
    biological regulation 11154
      regulation of biological process 10818
        signaling 6188
          signal transduction 5702
            ligand-gated ion channel signaling pathway 39
              ionotropic glutamate receptor signaling pathway + 27
              serotonin-gated cation-selective signaling pathway 0
paths to the root