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ONTOLOGY REPORT - ANNOTATIONS

Term:GLI-SUFU complex
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Accession:GO:1990788 term browser browse the term
Definition:A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins.
Comment:An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay).


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GLI-SUFU complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 part_of ISO (PMID:24311597) RGD PMID:24311597 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli3 GLI family zinc finger 3 part_of ISO (PMID:24311597) RGD PMID:24311597 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling part_of ISO (PMID:24311597) RGD PMID:24311597 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20811
    protein-containing complex 6431
      GLI-SUFU complex 3
Path 2
Term Annotations click to browse term
  cellular_component 20811
    cellular anatomical entity 20571
      intracellular anatomical structure 15179
        cytoplasm 11872
          cytosol 4228
            GLI-SUFU complex 3
paths to the root