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Term:GLI-SUFU complex
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Accession:GO:1990788 term browser browse the term
Definition:A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins.
Comment:An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay).
Synonyms:xref: IntAct:EBI-10170144;   IntAct:EBI-10828915;   IntAct:EBI-10828948;   IntAct:EBI-10828976;   IntAct:EBI-10828997;   IntAct:EBI-10829035

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  cellular_component 20126
    protein-containing complex 6038
      GLI-SUFU complex 0
Path 2
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  cellular_component 20126
    cellular anatomical entity 19825
      intracellular anatomical structure 14390
        cytoplasm 11380
          cytosol 4232
            GLI-SUFU complex 0
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