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ONTOLOGY REPORT - ANNOTATIONS


Term:endothelin production
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Accession:GO:1990775 term browser browse the term
Definition:The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions.
Synonyms:narrow_synonym: EDN1 production;   EDN2 production;   EDN3 production;   endothelin secretion;   endothelin-1 secretion;   endothelin-2 production;   endothelin-3 production



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negative regulation of endothelin production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:15560120 RGD:10043380 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
positive regulation of endothelin production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067-PRO_0000000093|UniProtKB:P12023-PRO_0000000119 (PMID:12808450)
Ensembl
RGD
PMID:12808450 GO_REF:0000107 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:Q62151 (PMID:12808450) RGD PMID:12808450 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Sulf2 sulfatase 2 IMP RGD PMID:30470661 RGD:401827838 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    multicellular organismal process 8969
      cytokine production 925
        endothelin production 4
          negative regulation of endothelin production 1
          positive regulation of endothelin production 3
          regulation of endothelin production + 4
Path 2
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      metabolic process 12160
        biosynthetic process 8651
          macromolecule biosynthetic process 7653
            gene expression 7211
              cytokine production 925
                endothelin production 4
                  negative regulation of endothelin production 1
                  positive regulation of endothelin production 3
                  regulation of endothelin production + 4
paths to the root