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ONTOLOGY REPORT - ANNOTATIONS

Term:PCSK9-LDLR complex
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Accession:GO:1990666 term browser browse the term
Definition:A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.
Synonyms:exact_synonym: PCSK9/LDL-R complex;   PCSK9:low-density lipoprotein receptor complex
 related_synonym: PCSK9:EGF-A complex


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PCSK9-LDLR complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldlr low density lipoprotein receptor part_of ISO
IEA		 (PMID:22081141), (PMID:22848640)
GO_REF:0000107		 RGD
Ensembl		 PMID:22081141 PMID:22848640 GO_REF:0000107 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 part_of ISO (PMID:22848640)
(PMID:22081141)		 RGD PMID:22081141 PMID:22848640 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20814
    protein-containing complex 6438
      PCSK9-LDLR complex 2
paths to the root