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ONTOLOGY REPORT - ANNOTATIONS

Term:calprotectin complex
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Accession:GO:1990660 term browser browse the term
Definition:A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways.
Comment:An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
Synonyms:narrow_synonym: calprotectin heterodimer


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calprotectin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G S100a8 S100 calcium binding protein A8 part_of ISO (PMID:25597447) RGD PMID:25597447 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 part_of IEA
ISO		 GO_REF:0000107
(PMID:25597447)		 Ensembl
RGD		 PMID:25597447 GO_REF:0000107 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
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  cellular_component 20813
    protein-containing complex 6433
      calprotectin complex 2
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