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ONTOLOGY REPORT - ANNOTATIONS

Term:C/EBP complex
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Accession:GO:1990647 term browser browse the term
Definition:A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities.
Comment:An example of this is Cebpa in rat (P05554) in PMID:8657121 (inferred from direct assay).
Synonyms:exact_synonym: C/EBP homodimer complex;   C/EBP transcription factor complex
 narrow_synonym: C/EBPalpha complex;   C/EBPalpha homodimer complex;   C/EBPbeta complex;   C/EBPbeta homodimer complex


show annotations for term's descendants           Sort by:
C/EBP complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpa CCAAT/enhancer binding protein alpha located_in ISO (PMID:20102225)
GO_REF:0000114		 RGD
ComplexPortal		 PMID:20102225 GO_REF:0000114 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta located_in
part_of		 ISO
IEA		 (PMID:20102225)
GO_REF:0000114
GO_REF:0000107
(MGI:6827204|PMID:17264204)		 RGD
ComplexPortal
Ensembl		 PMID:17264204 PMID:20102225 GO_REF:0000107 GO_REF:0000114 MGI:6827204 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      transcription regulator complex 542
        RNA polymerase II transcription regulator complex 253
          C/EBP complex 2
Path 2
Term Annotations click to browse term
  cellular_component 21392
    cellular anatomical entity 21234
      intracellular anatomical structure 15673
        intracellular organelle 13898
          intracellular membrane-bounded organelle 12331
            nucleus 7726
              nuclear protein-containing complex 1383
                RNA polymerase II transcription regulator complex 253
                  C/EBP complex 2
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