Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:ANPR-A receptor complex
go back to main search page
Accession:GO:1990620 term browser browse the term
Definition:A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.
Comment:An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay).
Synonyms:related_synonym: NPR1 receptor complex


show annotations for term's descendants           Sort by:
ANPR-A receptor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npr1 natriuretic peptide receptor 1 located_in IPI PMID:10894551 ComplexPortal PMID:10894551 RGD:150521653 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      receptor complex 456
        ANPR-A receptor complex 1
paths to the root