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ONTOLOGY REPORT - ANNOTATIONS
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Term:
IRE1-TRAF2-ASK1 complex
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Accession:
GO:1990604
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Definition:
A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K).
Synonyms:
related_synonym:
ERN1-TRAF2-ASK1 complex
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Genes (4)
IRE1-TRAF2-ASK1 complex
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Ern1
endoplasmic reticulum to nucleus signaling 1
part_of
ISO
IBA
(PMID:23000344)
GO_REF:0000033
RGD
GO_Central
PMID:23000344
GO_REF:0000033
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
G
Ern2
endoplasmic reticulum to nucleus signaling 2
part_of
ISO
IBA
(MGI:5616327|PMID:12050113)
GO_REF:0000033
RGD
GO_Central
PMID:12050113
GO_REF:0000033
MGI:5616327
NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289
G
Map3k5
mitogen-activated protein kinase kinase kinase 5
part_of
ISO
(PMID:12050113), (PMID:23000344)
RGD
PMID:12050113
PMID:23000344
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
G
Traf2
Tnf receptor-associated factor 2
part_of
ISO
ISS
(PMID:23000344)
GO_REF:0000024
(MGI:5616327|PMID:12050113)
RGD
ParkinsonsUK-UCL
PMID:12050113
PMID:23000344
GO_REF:0000024
MGI:5616327
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
Term paths to the root
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Path 1
Term
Annotations
cellular_component
20817
protein-containing complex
6437
endoplasmic reticulum protein-containing complex
130
IRE1-TRAF2-ASK1 complex
4
Path 2
Term
Annotations
cellular_component
20817
cellular anatomical entity
20577
organelle
14007
intracellular organelle
13599
intracellular membrane-bounded organelle
12056
endoplasmic reticulum
1882
endoplasmic reticulum subcompartment
1065
endoplasmic reticulum membrane
1055
IRE1-TRAF2-ASK1 complex
4