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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis

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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936637:3,543,615...4,023,710
Ensembl chrNW_004936637:3,545,211...4,022,630 		JBrowse link
G Cadps2 calcium dependent secretion activator 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936605:2,505,064...3,012,322
Ensembl chrNW_004936605:2,505,231...3,011,468 		JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chrNW_004936596:3,311,358...3,370,833
Ensembl chrNW_004936596:3,312,788...3,368,916 		JBrowse link
G Unc13b unc-13 homolog B NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chrNW_004936524:3,320,859...3,369,865 JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936596:3,311,358...3,370,833
Ensembl chrNW_004936596:3,312,788...3,368,916 		JBrowse link
G Unc13b unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936524:3,320,859...3,369,865 JBrowse link
G Unc13c unc-13 homolog C involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:15,691,357...16,225,590
Ensembl chrNW_004936471:15,691,647...16,224,147 		JBrowse link
G Unc13d unc-13 homolog D involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chrNW_004936594:1,008,215...1,023,023
Ensembl chrNW_004936594:1,008,327...1,021,878 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chrNW_004936517:3,035,840...3,044,065
Ensembl chrNW_004936517:3,035,521...3,047,964 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chrNW_004936596:3,311,358...3,370,833
Ensembl chrNW_004936596:3,312,788...3,368,916 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chrNW_004936524:3,320,859...3,369,865 JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936517:3,035,840...3,044,065
Ensembl chrNW_004936517:3,035,521...3,047,964 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chrNW_004936690:2,435,573...2,497,332
Ensembl chrNW_004936690:2,435,541...2,497,553 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in ISO (MGI:5634021|PMID:25719439)
(PMID:25719439)		 SynGO PMID:25719439 MGI:5634021 NCBI chrNW_004936637:3,543,615...4,023,710
Ensembl chrNW_004936637:3,545,211...4,022,630 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chrNW_004936618:3,678,400...4,047,994
Ensembl chrNW_004936618:3,606,524...4,047,711 		JBrowse link
G Snap25 synaptosome associated protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:9,198,744...9,279,854
Ensembl chrNW_004936485:9,195,110...9,279,920 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chrNW_004936487:15,300,758...15,367,475
Ensembl chrNW_004936487:15,300,952...15,365,713 		JBrowse link
G Syt10 synaptotagmin 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936607:2,940,607...2,995,178
Ensembl chrNW_004936607:2,940,466...2,994,344 		JBrowse link
G Unc13a unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936596:3,311,358...3,370,833
Ensembl chrNW_004936596:3,312,788...3,368,916 		JBrowse link
G Unc13b unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936524:3,320,859...3,369,865 JBrowse link
G Unc13c unc-13 homolog C involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:15,691,357...16,225,590
Ensembl chrNW_004936471:15,691,647...16,224,147 		JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1 associated protein 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936694:2,542,521...2,556,540
Ensembl chrNW_004936694:2,543,195...2,556,540 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936517:3,035,840...3,044,065
Ensembl chrNW_004936517:3,035,521...3,047,964 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chrNW_004936558:3,106,819...3,149,689
Ensembl chrNW_004936558:3,108,283...3,149,765 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chrNW_004936588:5,198,659...5,210,430
Ensembl chrNW_004936588:5,198,394...5,214,603 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936596:2,990,367...2,995,935
Ensembl chrNW_004936596:2,989,804...2,998,305 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chrNW_004936524:3,320,859...3,369,865 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16121
    localization 5229
      organelle localization 620
        vesicle localization 206
          establishment of vesicle localization 184
            dense core granule exocytosis 16
              dense core granule docking 2
              dense core granule priming 4
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 13
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 6
Path 2
Term Annotations click to browse term
  biological_process 16121
    localization 5229
      establishment of localization 4544
        transport 4256
          secretion 1102
            secretion by cell 948
              exocytosis 376
                regulated exocytosis 257
                  calcium-ion regulated exocytosis 80
                    dense core granule exocytosis 16
                      dense core granule docking 2
                      dense core granule priming 4
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 13
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 6
paths to the root