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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis


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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779 		JBrowse link
G Cadps2 calcium dependent secretion activator 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829 		JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A NOT|involved_in ISO UniProtKB:Q9Z1N9 (MGI:5819330|PMID:26575293) RGD PMID:26575293 MGI:5819330 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Unc13b unc-13 homolog B NOT|involved_in ISO UniProtKB:Q4KUS2 (MGI:5819330|PMID:26575293) RGD PMID:26575293 MGI:5819330 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in IGI
IBA		 PMID:26575293
GO_REF:0000033		 GO_Central PMID:26575293 GO_REF:0000033, RGD:12050107 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Unc13b unc-13 homolog B involved_in IGI
IBA		 PMID:26575293
GO_REF:0000033		 GO_Central PMID:26575293 GO_REF:0000033, RGD:12050107 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
G Unc13c unc-13 homolog C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223 		JBrowse link
G Unc13d unc-13 homolog D involved_in IGI PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr10:101,296,755...101,311,513
Ensembl chr10:101,296,776...101,311,687 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in IMP PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISS
ISO		 GO_REF:0000024
(MGI:5476894|PMID:23229896)		 UniProt
RGD		 PMID:23229896 GO_REF:0000024 MGI:5476894 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISS
ISO		 GO_REF:0000024
(MGI:5476894|PMID:23229896)		 UniProt
RGD		 PMID:23229896 GO_REF:0000024 MGI:5476894 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) RGD PMID:18468511 MGI:3795609 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt6 synaptotagmin 6 involved_in IDA
IMP		 PMID:26216953 SynGO PMID:26216953 PMID:26216953 RGD:13702162, RGD:13702162 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in ISO
IEA		 UniProtKB:Q8BYR5 (MGI:5634021|PMID:25719439), (PMID:25719439)
GO_REF:0000107		 RGD
Ensembl		 PMID:25719439 GO_REF:0000107 MGI:5634021 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) RGD PMID:31679900 NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631 		JBrowse link
G Snap25 synaptosome associated protein 25 involved_in IEA
ISO		 GO_REF:0000107
(PMID:28404788)		 Ensembl
RGD		 PMID:28404788 GO_REF:0000107 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) RGD PMID:11545717 MGI:3621672 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Syt10 synaptotagmin 10 involved_in ISO (PMID:28683263) RGD PMID:28683263 NCBI chr 7:120,857,698...120,920,863
Ensembl chr 7:120,862,972...120,920,863 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO
IBA		 UniProtKB:Q9Z1N9 (MGI:5819330|PMID:26575293)
GO_REF:0000033		 RGD
GO_Central		 PMID:26575293 GO_REF:0000033 MGI:5819330 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO
IBA		 (MGI:5819330|PMID:26575293)
GO_REF:0000033		 RGD
GO_Central		 PMID:26575293 GO_REF:0000033 MGI:5819330 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
G Unc13c unc-13 homolog C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223 		JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1-associated protein 3 involved_in ISO
IBA		 (PMID:28626000)
GO_REF:0000033		 RGD
GO_Central		 PMID:28626000 GO_REF:0000033 NCBI chr10:14,260,269...14,273,019
Ensembl chr10:14,260,269...14,273,019 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (PMID:19448629) RGD PMID:19448629 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in EXP
IDA		 PMID:24037803 SynGO PMID:24037803 PMID:24037803 RGD:13702177, RGD:13702177 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in IDA
IMP		 PMID:14627637 SynGO PMID:14627637 PMID:14627637 RGD:8554199, RGD:8554199 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IEA
ISO		 GO_REF:0000107
(PMID:31679900)		 Ensembl
RGD		 PMID:31679900 GO_REF:0000107 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Unc13b unc-13 homolog B involved_in IMP
IEP
IDA		 PMID:31679900 SynGO PMID:31679900 PMID:31679900 PMID:31679900 RGD:155230690, RGD:155230690, RGD:155230690 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    localization 5683
      organelle localization 626
        vesicle localization 204
          establishment of vesicle localization 182
            dense core granule exocytosis 16
              dense core granule docking 2
              dense core granule priming 4
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 13
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 6
Path 2
Term Annotations click to browse term
  biological_process 20115
    localization 5683
      establishment of localization 4990
        transport 4684
          secretion 1208
            secretion by cell 1013
              exocytosis 407
                regulated exocytosis 280
                  calcium-ion regulated exocytosis 83
                    dense core granule exocytosis 16
                      dense core granule docking 2
                      dense core granule priming 4
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 13
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 6
paths to the root