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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis


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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in IEA InterPro GO_REF:0000002 NCBI chr13:43,979,694...44,482,985 JBrowse link
G CADPS2 calcium dependent secretion activator 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr18:24,372,547...24,867,287
Ensembl chr18:24,372,544...24,867,482 		JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr 2:60,057,926...60,130,015 JBrowse link
G UNC13B unc-13 homolog B NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr 1:235,918,751...236,158,098
Ensembl chr 1:235,918,747...236,158,098 		JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:60,057,926...60,130,015 JBrowse link
G UNC13B unc-13 homolog B involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:235,918,751...236,158,098
Ensembl chr 1:235,918,747...236,158,098 		JBrowse link
G UNC13C unc-13 homolog C involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:117,163,115...117,765,125
Ensembl chr 1:117,166,300...117,723,335 		JBrowse link
G UNC13D unc-13 homolog D involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr12:5,573,428...5,598,914
Ensembl chr12:5,573,668...5,589,085 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr 6:127,382,248...127,392,258
Ensembl chr 6:127,382,263...127,392,164 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr 2:60,057,926...60,130,015 JBrowse link
G UNC13B unc-13 homolog B involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr 1:235,918,751...236,158,098
Ensembl chr 1:235,918,747...236,158,098 		JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chr 6:127,382,248...127,392,258
Ensembl chr 6:127,382,263...127,392,164 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chr 4:106,420,614...106,485,468
Ensembl chr 4:106,425,632...106,485,468 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:43,979,694...44,482,985 JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chr 1:51,785,140...52,246,456
Ensembl chr 1:51,785,495...52,244,934 		JBrowse link
G SNAP25 synaptosome associated protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:19,096,115...19,227,580
Ensembl chr17:19,141,464...19,227,576 		JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chr 1:268,116,124...268,205,805
Ensembl chr 1:268,116,120...268,205,778 		JBrowse link
G SYT10 synaptotagmin 10 involved_in ISO (PMID:28683263) SynGO PMID:28683263 NCBI chr 5:40,869,418...40,940,851
Ensembl chr 5:40,872,283...40,934,326 		JBrowse link
G UNC13A unc-13 homolog A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:60,057,926...60,130,015 JBrowse link
G UNC13B unc-13 homolog B involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:235,918,751...236,158,098
Ensembl chr 1:235,918,747...236,158,098 		JBrowse link
G UNC13C unc-13 homolog C involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:117,163,115...117,765,125
Ensembl chr 1:117,166,300...117,723,335 		JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAIAP3 BAI1 associated protein 3 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:40,536,557...40,550,508
Ensembl chr 3:40,537,399...40,550,471 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (PMID:19448629) SynGO PMID:19448629 NCBI chr 6:127,382,248...127,392,258
Ensembl chr 6:127,382,263...127,392,164 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chr 2:70,884,457...70,896,169
Ensembl chr 2:70,884,462...70,896,172 		JBrowse link
G RAB3A RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:59,603,090...59,609,773
Ensembl chr 2:59,603,117...59,609,767 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chr 1:235,918,751...236,158,098
Ensembl chr 1:235,918,747...236,158,098 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17634
    localization 5331
      organelle localization 606
        vesicle localization 200
          establishment of vesicle localization 178
            dense core granule exocytosis 16
              dense core granule docking 2
              dense core granule priming 4
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 13
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 6
Path 2
Term Annotations click to browse term
  biological_process 17634
    localization 5331
      establishment of localization 4641
        transport 4353
          secretion 1134
            secretion by cell 971
              exocytosis 373
                regulated exocytosis 257
                  calcium-ion regulated exocytosis 74
                    dense core granule exocytosis 16
                      dense core granule docking 2
                      dense core granule priming 4
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 13
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 6
paths to the root