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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis

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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624888:2,985,966...3,443,542 JBrowse link
G Cadps2 calcium dependent secretion activator 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624783:13,142,036...13,701,430
Ensembl chrNW_004624783:13,142,198...13,700,683 		JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chrNW_004624908:418,248...464,203 JBrowse link
G Unc13b unc-13 homolog B NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chrNW_004624915:327,633...530,522
Ensembl chrNW_004624915:327,401...531,886 		JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624908:418,248...464,203 JBrowse link
G Unc13b unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624915:327,633...530,522
Ensembl chrNW_004624915:327,401...531,886 		JBrowse link
G Unc13d unc-13 homolog D involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chrNW_004624801:5,720,998...5,736,122
Ensembl chrNW_004624801:5,721,391...5,736,294 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chrNW_004624779:17,593,760...17,603,217
Ensembl chrNW_004624779:17,592,669...17,603,403 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chrNW_004624908:418,248...464,203 JBrowse link
G Unc13b unc-13 homolog B involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chrNW_004624915:327,633...530,522
Ensembl chrNW_004624915:327,401...531,886 		JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chrNW_004624779:17,593,760...17,603,217
Ensembl chrNW_004624779:17,592,669...17,603,403 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chrNW_004624772:9,753,485...9,810,815
Ensembl chrNW_004624772:9,753,416...9,810,757 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in ISO (MGI:5634021|PMID:25719439)
(PMID:25719439)		 SynGO PMID:25719439 MGI:5634021 NCBI chrNW_004624888:2,985,966...3,443,542 JBrowse link
G Snap25 synaptosome associated protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624741:11,218,259...11,303,406
Ensembl chrNW_004624741:11,274,490...11,302,813 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chrNW_004624760:7,843,741...7,914,444
Ensembl chrNW_004624760:7,842,640...7,914,484 		JBrowse link
G Syt10 synaptotagmin 10 involved_in ISO (PMID:28683263) SynGO PMID:28683263 NCBI chrNW_004624778:2,700,545...2,763,134 JBrowse link
G Unc13a unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624908:418,248...464,203 JBrowse link
G Unc13b unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624915:327,633...530,522
Ensembl chrNW_004624915:327,401...531,886 		JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1 associated protein 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624913:2,045,702...2,060,092
Ensembl chrNW_004624913:2,045,721...2,060,092 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (PMID:19448629) SynGO PMID:19448629 NCBI chrNW_004624779:17,593,760...17,603,217
Ensembl chrNW_004624779:17,592,669...17,603,403 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chrNW_004624747:21,725,813...21,768,123
Ensembl chrNW_004624747:21,725,395...21,759,453 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chrNW_004624828:1,165,877...1,174,306
Ensembl chrNW_004624828:1,165,327...1,174,417 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chrNW_004624908:1,532,857...1,537,159
Ensembl chrNW_004624908:1,530,312...1,536,129 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chrNW_004624915:327,633...530,522
Ensembl chrNW_004624915:327,401...531,886 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15225
    localization 5008
      organelle localization 595
        vesicle localization 193
          establishment of vesicle localization 171
            dense core granule exocytosis 14
              dense core granule docking 2
              dense core granule priming 3
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 11
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 6
Path 2
Term Annotations click to browse term
  biological_process 15225
    localization 5008
      establishment of localization 4352
        transport 4073
          secretion 1072
            secretion by cell 928
              exocytosis 362
                regulated exocytosis 252
                  calcium-ion regulated exocytosis 73
                    dense core granule exocytosis 14
                      dense core granule docking 2
                      dense core granule priming 3
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 11
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 6
paths to the root