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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis


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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps Ca2+-dependent secretion activator involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr14:9,646,424...10,097,203
Ensembl chr14:9,646,684...10,097,200 		JBrowse link
G Cadps2 Ca2+-dependent activator protein for secretion 2 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 6:23,262,765...23,840,662
Ensembl chr 6:23,262,772...23,839,420 		JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A NOT|involved_in IGI (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr 8:72,079,356...72,124,418
Ensembl chr 8:72,077,061...72,124,401 		JBrowse link
G Unc13b unc-13 homolog B NOT|involved_in IGI (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr 4:43,046,193...43,264,873
Ensembl chr 4:43,058,953...43,264,871 		JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000096 MGI:4417868 NCBI chr 8:72,079,356...72,124,418
Ensembl chr 8:72,077,061...72,124,401 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000096 MGI:4417868 NCBI chr 4:43,046,193...43,264,873
Ensembl chr 4:43,058,953...43,264,871 		JBrowse link
G Unc13d unc-13 homolog D involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr11:115,952,921...115,969,321
Ensembl chr11:115,952,921...115,968,787 		JBrowse link
G Unc13h3 unc13 homolog (C. elegans) 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:73,386,704...73,915,421
Ensembl chr 9:73,386,704...73,876,248 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin IV involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr18:31,570,861...31,580,468
Ensembl chr18:31,570,861...31,580,459 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in IMP (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr 8:72,079,356...72,124,418
Ensembl chr 8:72,077,061...72,124,401 		JBrowse link
G Unc13b unc-13 homolog B involved_in IMP (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr 4:43,046,193...43,264,873
Ensembl chr 4:43,058,953...43,264,871 		JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin IV involved_in IMP (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chr18:31,570,861...31,580,468
Ensembl chr18:31,570,861...31,580,459 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt6 synaptotagmin VI involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 3:103,482,561...103,552,883
Ensembl chr 3:103,482,547...103,552,885 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps Ca2+-dependent secretion activator involved_in IGI
IDA
IMP		 (MGI:5634021|PMID:25719439)
(PMID:25719439)		 SynGO PMID:25719439 MGI:5634021 NCBI chr14:9,646,424...10,097,203
Ensembl chr14:9,646,684...10,097,200 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in IEP
IMP
IDA		 (PMID:31679900) SynGO PMID:31679900 NCBI chr 1:22,356,196...22,845,239
Ensembl chr 1:22,356,475...22,845,203 		JBrowse link
G Snap25 synaptosomal-associated protein 25 involved_in IEP
IDA
IMP		 (PMID:28404788) SynGO PMID:28404788 NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in IMP (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257 		JBrowse link
G Syt10 synaptotagmin X involved_in IMP
IDA		 (PMID:28683263) SynGO PMID:28683263 NCBI chr15:89,657,221...89,726,181
Ensembl chr15:89,666,596...89,726,063 		JBrowse link
G Unc13a unc-13 homolog A involved_in IGI
IBA		 (MGI:5819330|PMID:26575293) SynGO
GO_Central		 PMID:26575293 GO_REF:0000033 MGI:5819330 NCBI chr 8:72,079,356...72,124,418
Ensembl chr 8:72,077,061...72,124,401 		JBrowse link
G Unc13b unc-13 homolog B involved_in IMP
IBA		 (MGI:5819330|PMID:26575293) SynGO
GO_Central		 PMID:26575293 GO_REF:0000033 MGI:5819330 NCBI chr 4:43,046,193...43,264,873
Ensembl chr 4:43,058,953...43,264,871 		JBrowse link
G Unc13h3 unc13 homolog (C. elegans) 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:73,386,704...73,915,421
Ensembl chr 9:73,386,704...73,876,248 		JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gm937 gene model 937, (NCBI) involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr17:25,461,633...25,475,255
Ensembl chr17:25,461,633...25,475,338 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin IV involved_in IDA
EXP
IMP		 (PMID:19448629) SynGO PMID:19448629 NCBI chr18:31,570,861...31,580,468
Ensembl chr18:31,570,861...31,580,459 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in IMP
IEP
IDA		 (PMID:31679900) SynGO PMID:31679900 NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 4:43,046,193...43,264,873
Ensembl chr 4:43,058,953...43,264,871 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28702
    localization 5604
      organelle localization 655
        vesicle localization 224
          establishment of vesicle localization 202
            dense core granule exocytosis 16
              dense core granule docking 2
              dense core granule priming 4
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 13
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 6
Path 2
Term Annotations click to browse term
  biological_process 28702
    localization 5604
      establishment of localization 4907
        transport 4593
          secretion 1224
            secretion by cell 1033
              exocytosis 416
                regulated exocytosis 280
                  calcium-ion regulated exocytosis 78
                    dense core granule exocytosis 16
                      dense core granule docking 2
                      dense core granule priming 4
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 13
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 6
paths to the root