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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis

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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in IEA InterPro GO_REF:0000002 NCBI chr22:23,471,616...23,948,694 JBrowse link
G CADPS2 calcium dependent secretion activator 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr21:91,117,749...91,669,284 JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103219228 protein unc-13 homolog B NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr12:45,230,661...45,461,934
Ensembl chr12:45,230,659...45,461,339 		JBrowse link
G UNC13A unc-13 homolog A NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr 6:16,082,703...16,167,165
Ensembl chr 6:16,084,168...16,154,812 		JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103219228 protein unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:45,230,661...45,461,934
Ensembl chr12:45,230,659...45,461,339 		JBrowse link
G UNC13A unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:16,082,703...16,167,165
Ensembl chr 6:16,084,168...16,154,812 		JBrowse link
G UNC13C unc-13 homolog C involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr26:28,806,368...29,196,031 JBrowse link
G UNC13D unc-13 homolog D involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr16:45,836,659...45,856,805
Ensembl chr16:45,838,175...45,857,201 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr18:37,595,187...37,604,931
Ensembl chr18:37,595,035...37,606,007 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103219228 protein unc-13 homolog B involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr12:45,230,661...45,461,934
Ensembl chr12:45,230,659...45,461,339 		JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr 6:16,082,703...16,167,165
Ensembl chr 6:16,084,168...16,154,812 		JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chr18:37,595,187...37,604,931
Ensembl chr18:37,595,035...37,606,007 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chr20:19,497,218...19,561,621
Ensembl chr20:19,512,540...19,563,038 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in ISO (MGI:5634021|PMID:25719439)
(PMID:25719439)		 SynGO PMID:25719439 MGI:5634021 NCBI chr22:23,471,616...23,948,694 JBrowse link
G LOC103219228 protein unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:45,230,661...45,461,934
Ensembl chr12:45,230,659...45,461,339 		JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chr17:2,690,430...3,176,794
Ensembl chr17:2,690,418...3,176,738 		JBrowse link
G SNAP25 synaptosome associated protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:27,857,093...27,944,487
Ensembl chr 2:27,858,319...27,944,496 		JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chr12:10,440,061...10,519,798
Ensembl chr12:10,439,801...10,519,777 		JBrowse link
G SYT10 synaptotagmin 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:32,846,425...32,914,946
Ensembl chr11:32,850,902...32,914,464 		JBrowse link
G UNC13A unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:16,082,703...16,167,165
Ensembl chr 6:16,084,168...16,154,812 		JBrowse link
G UNC13C unc-13 homolog C involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr26:28,806,368...29,196,031 JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAIAP3 BAI1 associated protein 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:1,222,994...1,237,823
Ensembl chr 5:1,227,910...1,236,898 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (PMID:19448629) SynGO PMID:19448629 NCBI chr18:37,595,187...37,604,931
Ensembl chr18:37,595,035...37,606,007 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103219228 protein unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chr12:45,230,661...45,461,934
Ensembl chr12:45,230,659...45,461,339 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chr 6:7,743,130...7,757,237
Ensembl chr 6:7,743,361...7,757,305 		JBrowse link
G RAB3A RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:16,671,388...16,678,780
Ensembl chr 6:16,670,431...16,678,644 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17080
    localization 5434
      organelle localization 631
        vesicle localization 205
          establishment of vesicle localization 181
            dense core granule exocytosis 16
              dense core granule docking 2
              dense core granule priming 4
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 13
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 6
Path 2
Term Annotations click to browse term
  biological_process 17080
    localization 5434
      establishment of localization 4718
        transport 4416
          secretion 1150
            secretion by cell 985
              exocytosis 392
                regulated exocytosis 271
                  calcium-ion regulated exocytosis 78
                    dense core granule exocytosis 16
                      dense core granule docking 2
                      dense core granule priming 4
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 13
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 6
paths to the root