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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis


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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in IEA InterPro GO_REF:0000002 NCBI chr20:28,221,150...28,680,844
Ensembl chr20:28,221,843...28,680,131 		JBrowse link
G CADPS2 calcium dependent secretion activator 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr14:60,109,253...60,465,982
Ensembl chr14:60,107,538...60,556,817 		JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr20:45,179,275...45,237,544
Ensembl chr20:45,188,750...45,238,115 		JBrowse link
G UNC13B unc-13 homolog B NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr11:51,707,968...51,941,148
Ensembl chr11:51,708,302...51,940,955 		JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr20:45,179,275...45,237,544
Ensembl chr20:45,188,750...45,238,115 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr11:51,707,968...51,941,148
Ensembl chr11:51,708,302...51,940,955 		JBrowse link
G UNC13D unc-13 homolog D involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr 9:4,753,300...4,766,751
Ensembl chr 9:4,753,166...4,766,756 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr 7:47,555,110...47,565,313
Ensembl chr 7:47,509,852...47,563,714 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr20:45,179,275...45,237,544
Ensembl chr20:45,188,750...45,238,115 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr11:51,707,968...51,941,148
Ensembl chr11:51,708,302...51,940,955 		JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chr 7:47,555,110...47,565,313
Ensembl chr 7:47,509,852...47,563,714 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chr17:51,859,564...51,923,044
Ensembl chr17:51,864,774...51,924,676 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:28,221,150...28,680,844
Ensembl chr20:28,221,843...28,680,131 		JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chr12:34,473,974...34,661,893
Ensembl chr12:34,474,033...34,659,410 		JBrowse link
G SNAP25 synaptosome associated protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:12,003,005...12,081,385
Ensembl chr24:12,004,117...12,081,329 		JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chr 9:55,690,939...55,768,008
Ensembl chr 9:55,678,264...55,727,680 		JBrowse link
G SYT10 synaptotagmin 10 involved_in ISO (PMID:28683263) SynGO PMID:28683263 NCBI chr27:15,593,709...15,657,184
Ensembl chr27:15,593,649...15,687,920 		JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (MGI:5819330|PMID:26575293) SynGO PMID:26575293 MGI:5819330 NCBI chr20:45,179,275...45,237,544
Ensembl chr20:45,188,750...45,238,115 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO (MGI:5819330|PMID:26575293) SynGO PMID:26575293 MGI:5819330 NCBI chr11:51,707,968...51,941,148
Ensembl chr11:51,708,302...51,940,955 		JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAIAP3 BAI1 associated protein 3 involved_in ISO (PMID:28626000) UniProt PMID:28626000 NCBI chr 6:39,421,019...39,434,539
Ensembl chr 6:39,427,520...39,435,596 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (PMID:19448629) SynGO PMID:19448629 NCBI chr 7:47,555,110...47,565,313
Ensembl chr 7:47,509,852...47,563,714 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chr20:52,955,949...52,966,279
Ensembl chr20:52,956,529...52,965,383 		JBrowse link
G RAB3A RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:44,796,740...44,802,224
Ensembl chr20:44,796,895...44,801,692 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chr11:51,707,968...51,941,148
Ensembl chr11:51,708,302...51,940,955 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17068
    localization 5310
      organelle localization 574
        vesicle localization 186
          establishment of vesicle localization 163
            dense core granule exocytosis 15
              dense core granule docking 2
              dense core granule priming 3
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 12
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 6
Path 2
Term Annotations click to browse term
  biological_process 17068
    localization 5310
      establishment of localization 4647
        transport 4361
          secretion 1122
            secretion by cell 958
              exocytosis 363
                regulated exocytosis 253
                  calcium-ion regulated exocytosis 65
                    dense core granule exocytosis 15
                      dense core granule docking 2
                      dense core granule priming 3
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 12
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 6
paths to the root