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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis

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dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chrNW_004955524:725,353...769,745 JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chrNW_004955524:725,353...769,745 JBrowse link
G Unc13d unc-13 homolog D involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chrNW_004955506:6,407,073...6,423,406
Ensembl chrNW_004955506:6,407,723...6,423,406 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chrNW_004955402:29,195,124...29,204,816
Ensembl chrNW_004955402:29,193,455...29,204,975 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Unc13a unc-13 homolog A involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chrNW_004955524:725,353...769,745 JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chrNW_004955402:29,195,124...29,204,816
Ensembl chrNW_004955402:29,193,455...29,204,975 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chrNW_004955435:17,349,971...17,405,526
Ensembl chrNW_004955435:17,347,011...17,405,526 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadps calcium dependent secretion activator involved_in ISO (MGI:5634021|PMID:25719439)
(PMID:25719439)		 SynGO PMID:25719439 MGI:5634021 NCBI chrNW_004955517:2,965,471...3,420,183 JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chrNW_004955488:6,999,128...7,196,583
Ensembl chrNW_004955488:6,936,952...7,197,022 		JBrowse link
G Snap25 synaptosome associated protein 25 involved_in ISO (PMID:28404788) SynGO PMID:28404788 NCBI chrNW_004955415:20,133,361...20,218,840
Ensembl chrNW_004955415:20,133,201...20,219,023 		JBrowse link
G Stxbp1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chrNW_004955419:963,829...1,000,759
Ensembl chrNW_004955419:963,829...1,000,759 		JBrowse link
G Syt10 synaptotagmin 10 involved_in ISO (PMID:28683263) SynGO PMID:28683263 NCBI chrNW_004955505:2,392,086...2,449,528
Ensembl chrNW_004955505:2,403,055...2,449,528 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (MGI:5819330|PMID:26575293) SynGO PMID:26575293 MGI:5819330 NCBI chrNW_004955524:725,353...769,745 JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1 associated protein 3 involved_in ISO (PMID:28626000) UniProt PMID:28626000 NCBI chrNW_004955442:15,884,034...15,897,894
Ensembl chrNW_004955442:15,884,034...15,898,396 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (PMID:19448629) SynGO PMID:19448629 NCBI chrNW_004955402:29,195,124...29,204,816
Ensembl chrNW_004955402:29,193,455...29,204,975 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chrNW_004955482:7,048,674...7,087,525
Ensembl chrNW_004955482:7,048,776...7,086,926 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chrNW_004955563:1,008,267...1,017,315
Ensembl chrNW_004955563:1,008,769...1,017,315 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chrNW_004955524:3,220,108...3,224,376
Ensembl chrNW_004955524:3,221,366...3,224,376 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12482
    localization 4338
      organelle localization 522
        vesicle localization 172
          establishment of vesicle localization 149
            dense core granule exocytosis 13
              dense core granule docking 1
              dense core granule priming 2
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 11
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 5
Path 2
Term Annotations click to browse term
  biological_process 12482
    localization 4338
      establishment of localization 3675
        transport 3407
          secretion 1002
            secretion by cell 866
              exocytosis 315
                regulated exocytosis 235
                  calcium-ion regulated exocytosis 61
                    dense core granule exocytosis 13
                      dense core granule docking 1
                      dense core granule priming 2
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 11
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 5
paths to the root