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ONTOLOGY REPORT - ANNOTATIONS

Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis


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dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:62,321,496...62,797,298 JBrowse link
G CADPS2 calcium dependent secretion activator 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:114,328,933...114,896,388
Ensembl chr 7:127,014,772...127,579,249 		JBrowse link
dense core granule docking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642 		JBrowse link
G UNC13B unc-13 homolog B NOT|involved_in ISO (MGI:5819330|PMID:26575293) SynGO-UCL PMID:26575293 MGI:5819330 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894 		JBrowse link
dense core granule priming term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642 		JBrowse link
G UNC13B unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894 		JBrowse link
G UNC13D unc-13 homolog D involved_in ISO PMID:26575293 SynGO-UCL PMID:26575293 RGD:12050107 NCBI chr17:69,777,570...69,794,877
Ensembl chr17:75,328,572...75,344,842 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr18:36,540,756...36,550,439
Ensembl chr18:40,089,938...40,099,721 		JBrowse link
neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UNC13A unc-13 homolog A involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894 		JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chr18:36,540,756...36,550,439
Ensembl chr18:40,089,938...40,099,721 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chr 1:88,397,809...88,467,493
Ensembl chr 1:123,452,889...123,514,795 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:62,321,496...62,797,298 JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chr 6:69,714,807...70,231,260
Ensembl chr 6:73,008,176...73,523,422 		JBrowse link
G SNAP25 synaptosome associated protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:10,164,236...10,252,856
Ensembl chr20:10,218,358...10,252,841 		JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chr 9:98,731,527...98,811,608
Ensembl chr 9:127,434,080...127,486,152 		JBrowse link
G SYT10 synaptotagmin 10 involved_in ISO (PMID:28683263) SynGO PMID:28683263 NCBI chr12:52,761,294...52,830,221
Ensembl chr12:55,364,714...55,429,298 		JBrowse link
G UNC13A unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642 		JBrowse link
G UNC13B unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894 		JBrowse link
regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAIAP3 BAI1 associated protein 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr16:1,390,160...1,403,978 JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (PMID:19448629) SynGO PMID:19448629 NCBI chr18:36,540,756...36,550,439
Ensembl chr18:40,089,938...40,099,721 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chr19:7,676,095...7,690,177 JBrowse link
G RAB3A RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:17,672,661...17,679,541
Ensembl chr19:18,649,166...18,656,768 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16768
    localization 5348
      organelle localization 638
        vesicle localization 205
          establishment of vesicle localization 183
            dense core granule exocytosis 15
              dense core granule docking 2
              dense core granule priming 3
              negative regulation of dense core granule exocytosis 1
              neuronal dense core vesicle exocytosis + 12
              positive regulation of dense core granule exocytosis 1
              regulation of dense core granule exocytosis + 6
Path 2
Term Annotations click to browse term
  biological_process 16768
    localization 5348
      establishment of localization 4649
        transport 4352
          secretion 1130
            secretion by cell 965
              exocytosis 375
                regulated exocytosis 260
                  calcium-ion regulated exocytosis 74
                    dense core granule exocytosis 15
                      dense core granule docking 2
                      dense core granule priming 3
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 12
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis + 6
paths to the root