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ONTOLOGY REPORT - ANNOTATIONS


Term:raps-insc complex
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Accession:GO:1990499 term browser browse the term
Definition:Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2).
Comment:An example of this is Insc in drome (Q9W2R4) in PMID:22171003 (inferred from physical interaction).
Synonyms:exact_synonym: Rapsynoid-Inscuteable complex;   partner of inscuteable-inscuteable complex
 xref: IntAct:EBI-9674411


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  cellular_component 20602
    protein-containing complex 6103
      raps-insc complex 0
Path 2
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  cellular_component 20602
    cellular anatomical entity 20292
      intracellular anatomical structure 14638
        cytoplasm 11463
          cytoplasmic region 295
            cell cortex region 55
              apical cortex 12
                raps-insc complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.