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Term:Rhino-Deadlock-Cutoff Complex
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Accession:GO:1990469 term browser browse the term
Definition:Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation.
Comment:An example of this is cuff in Drosophila melanogaster (Q9V629) in PMID:24906153.
Synonyms:exact_synonym: RDC complex;   rhi-del-cuff complex

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  cellular_component 20534
    protein-containing complex 6321
      nuclear protein-containing complex 1283
        Rhino-Deadlock-Cutoff Complex 0
Path 2
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  cellular_component 20534
    cellular anatomical entity 20291
      organelle 13525
        membrane-bounded organelle 12075
          intracellular membrane-bounded organelle 11565
            nucleus 7215
              germ cell nucleus 109
                Rhino-Deadlock-Cutoff Complex 0
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