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Term:PTEN phosphatase complex
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Accession:GO:1990455 term browser browse the term
Definition:A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function.
Comment:An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
Synonyms:exact_synonym: phosphatase and tensin homolog;   phosphatase and tensin homolog deleted on chromosome ten homodimer;   phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer

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  cellular_component 21308
    protein-containing complex 6932
      catalytic complex 1940
        phosphatase complex 56
          phosphatidylinositol phosphate phosphatase complex 0
            PTEN phosphatase complex 0
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